Computational analysis of the human sinus node action potential: model development and effects of mutations

Electrophysiology meets geometry

(2015) Antonio Zaza   EUROPACE

A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial Inappropriate Sinus Tachycardia

(2015) Mirko Baruscotti et al.   EUROPEAN HEART JOURNAL

Pacemaker Activity of the Human Sinoatrial Node: An Update on the Effects of Mutations in HCN4 on the Hyperpolarization-Activated Current

(2015) Arie Verkerk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HCN4 Mutations in Multiple Families With Bradycardia and Left Ventricular Noncompaction Cardiomyopathy

(2014) Annalisa Milano et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Symptom Complex of Familial Sinus Node Dysfunction and Myocardial Noncompaction Is Associated With Mutations in the HCN4 Channel

(2014) Patrick A. Schweizer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Overlapping Cardiac Phenotype Associated with a Familial Mutation in the Voltage Sensor of the KCNQ1 Channel

(2013) Ulrike Henrion et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: Bradycardic effects of ivabradine are linked to suppression of intracellular Ca2+ cycling

(2013) Yael Yaniv et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A KCNQ1 mutation causes age-dependant bradycardia and persistent atrial fibrillation

(2013) Chang-Seok Ki et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Modern Concepts Concerning the Origin of the Heartbeat

(2013) Oliver Monfredi et al.   PHYSIOLOGY

Calcium Transient and Sodium-Calcium Exchange Current in Human versus Rabbit Sinoatrial Node Pacemaker Cells

(2013) Arie O. Verkerk et al.   TheScientificWorldJOURNAL

Exploration of human, rat, and rabbit embryonic cardiomyocytes suggests K-channel block as a common teratogenic mechanism

(2012) Christian Danielsson et al.   CARDIOVASCULAR RESEARCH

Altered HCN4 channel C-linker interaction is associated with familial tachycardia–bradycardia syndrome and atrial fibrillation

(2012) Nana Duhme et al.   EUROPEAN HEART JOURNAL

Is sodium current present in human sinoatrial node cells?

(2012) Arie O. Verkerk et al.   International Journal of Biological Sciences

An updated computational model of rabbit sinoatrial action potential to investigate the mechanisms of heart rate modulation

(2012) Stefano Severi et al.   JOURNAL OF PHYSIOLOGY-LONDON

A mathematical model of action potentials of mouse sinoatrial node cells with molecular bases

(2011) Sanjay Kharche et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Human Atrial Action Potential and Ca 2+ Model

(2011) Eleonora Grandi et al.   CIRCULATION RESEARCH

Rebuttal: What If the shoe doesn't fit? “The funny current has a major pacemaking role in the sinus node”

(2011) Edward G. Lakatta et al.   HEART RHYTHM

The case for the funny current and the calcium clock

(2011) Michael R. Rosen et al.   HEART RHYTHM

The funny current has a major pacemaking role in the sinus node

(2011) Dario DiFrancesco et al.   HEART RHYTHM

Minor contribution of cytosolic Ca2+ transients to the pacemaker rhythm in guinea pig sinoatrial node cells

(2010) Yukiko Himeno et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Competing Oscillators in Cardiac Pacemaking

(2010) Denis Noble et al.   CIRCULATION RESEARCH

A Coupled SYSTEM of Intracellular Ca 2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker

(2010) Edward G. Lakatta et al.   CIRCULATION RESEARCH

The Role of the Funny Current in Pacemaker Activity

(2010) Dario DiFrancesco   CIRCULATION RESEARCH

A Novel Mutation in the HCN4 Gene Causes Symptomatic Sinus Bradycardia in Moroccan Jews

(2010) AVISHAG LAISH-FARKASH et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Relative importance of funny current in human versus rabbit sinoatrial node

(2010) Arie O. Verkerk et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Regression Analysis for Constraining Free Parameters in Electrophysiological Models of Cardiac Cells

(2010) Amrita X. Sarkar et al.   PLoS Computational Biology

K+ current changes account for the rate dependence of the action potential in the human atrial myocyte

(2009) Mary M. Maleckar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model

(2009) Victor A. Maltsev et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Parameter Sensitivity Analysis in Electrophysiological Models Using Multivariable Regression

(2009) Eric A. Sobie   BIOPHYSICAL JOURNAL

Molecular Architecture of the Human Sinus Node

(2009) Natalie J. Chandler et al.   CIRCULATION

A paradigm shift for the heart's pacemaker

(2009) Edward G. Lakatta   HEART RHYTHM

Pacemaker activity of the human sinoatrial node: Role of the hyperpolarization-activated current, If

(2009) Arie O. Verkerk et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

What keeps us ticking: a funny current, a calcium clock, or both?

(2009) Edward G. Lakatta et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Funny current provides a relatively modest contribution to spontaneous beating rate regulation of human and rabbit sinoatrial node cells

(2009) Victor A. Maltsev et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

From in vivo plasma composition to in vitro cardiac electrophysiology and in silico virtual heart: the extracellular calcium enigma

(2009) S. Severi et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Ionic Mechanisms Underlying the Positive Chronotropy Induced by β1-Adrenergic Stimulation in Guinea Pig Sinoatrial Node Cells: a Simulation Study

(2008) Yukiko Himeno et al.   Journal of Physiological Sciences