Activation of CXCL6/CXCR1/2 Axis Promotes the Growth and Metastasis of Osteosarcoma Cells in vitro and in vivo

Blocking CXCLs–CXCR2 axis in tumor–stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion/migration and a shift of immune-inflammatory microenvironment

(2019) Makoto Sano et al.   Oncogenesis

CXCL6 promotes non-small cell lung cancer cell survival and metastasis via down-regulation of miR-515-5p

(2018) Jun Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Isoliquiritigenin Suppresses Osteosarcoma U2OS Cell Proliferation and Invasion by Regulating the PI3K/Akt Signalling Pathway

(2018) Jing Chen et al.   CHEMOTHERAPY

Chemokine CXCL3 mediates prostate cancer cells proliferation, migration and gene expression changes in an autocrine/paracrine fashion

(2018) Hua Xin et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

GPNMB silencing suppresses the proliferation and metastasis of osteosarcoma cells by blocking the PI3K/Akt/mTOR signaling pathway

(2018) Rui Jin et al.   ONCOLOGY REPORTS

Dual roles of miR-374a by modulated c-Jun respectively targets CCND1-inducing PI3K/AKT signal and PTEN-suppressing Wnt/β-catenin signaling in non-small-cell lung cancer

(2018) Mengyang Zhao et al.   Cell Death & Disease

CXCR1/Akt signaling activation induced by mesenchymal stem cell-derived IL-8 promotes osteosarcoma cell anoikis resistance and pulmonary metastasis

(2018) Lin Du et al.   Cell Death & Disease

A small-molecule antagonist of CXCR1 and CXCR2 inhibits cell proliferation, migration and invasion in melanoma via PI3K/AKT pathway

(2018) Fu-min Shang et al.   MEDICINA CLINICA

Fibulin-4 promotes osteosarcoma invasion and metastasis by inducing epithelial to mesenchymal transition via the PI3K/Akt/mTOR pathway

(2017) Dong Zhang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways

(2017) Jingkun Zhao et al.   Molecular Cancer

A positive crosstalk between CXCR4 and CXCR2 promotes gastric cancer metastasis

(2017) Z Xiang et al.   ONCOGENE

Fibroblast-derived CXCL12/SDF-1α promotes CXCL6 secretion and co-operatively enhances metastatic potential through the PI3K/Akt/mTOR pathway in colon cancer

(2017) Jia-Chi Ma et al.   WORLD JOURNAL OF GASTROENTEROLOGY

MicroRNA-610 suppresses osteosarcoma oncogenicity via targeting TWIST1 expression

(2017) Chi Jin et al.   Oncotarget

Network-pharmacology-based validation of TAMS/CXCL-1 as key mediator of XIAOPI formula preventing breast cancer development and metastasis

(2017) Neng Wang et al.   Scientific Reports

The CXCL8-CXCR1/2 pathways in cancer

(2016) Qian Liu et al.   CYTOKINE & GROWTH FACTOR REVIEWS

CXCL7 promotes proliferation and invasion of cholangiocarcinoma cells

(2016) Qian Guo et al.   ONCOLOGY REPORTS

miR-940 Suppresses Tumor Cell Invasion and Migration via Regulation of CXCR2 in Hepatocellular Carcinoma

(2016) Dong Ding et al.   Biomed Research International

The prognostic value of CXC-chemokine receptor 2 (CXCR2) in gastric cancer patients

(2015) Zhenglin Wang et al.   BMC CANCER

CXCR2/CXCL5 axis contributes to epithelial–mesenchymal transition of HCC cells through activating PI3K/Akt/GSK-3β/Snail signaling

(2015) Shao-Lai Zhou et al.   CANCER LETTERS

Imipramine blue halts head and neck cancer invasion through promoting F-box and leucine-rich repeat protein 14-mediated Twist1 degradation

(2015) W-H Yang et al.   ONCOGENE

CCL20 and CXCL8 synergize to promote progression and poor survival outcome in patients with colorectal cancer by collaborative induction of the epithelial–mesenchymal transition

(2014) Xian-Shuo Cheng et al.   CANCER LETTERS

HIF-1a Plays a Role in the Chemotactic Migration of Hepatocarcinoma Cells Through the Modulation of CXCL6 Expression

(2014) Hui Tian et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Silencing of galectin-3 represses osteosarcoma cell migration and invasion through inhibition of FAK/Src/Lyn activation and β-catenin expression and increases susceptibility to chemotherapeutic agents

(2014) GA BIN PARK et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

CXCR4 drives the metastatic phenotype in breast cancer through induction of CXCR2 and activation of MEK and PI3K pathways

(2014) Tammy Sobolik et al.   MOLECULAR BIOLOGY OF THE CELL

The CXCL7/CXCR1/2 Axis Is a Key Driver in the Growth of Clear Cell Renal Cell Carcinoma

(2013) R. Grepin et al.   CANCER RESEARCH

PI3K/Akt to GSK3β/β-catenin signaling cascade coordinates cell colonization for bladder cancer bone metastasis through regulating ZEB1 transcription

(2012) Kaijie Wu et al.   CELLULAR SIGNALLING

PI3K/Akt-dependent phosphorylation of GSK3β and activation of RhoA regulate Wnt5a-induced gastric cancer cell migration

(2012) Jiaojing Liu et al.   CELLULAR SIGNALLING

Isotypic neutralizing antibodies against mouse GCP-2/CXCL6 inhibit melanoma growth and metastasis

(2011) Hannelien Verbeke et al.   CANCER LETTERS

Elevated expression of CXC chemokines in pediatric osteosarcoma patients

(2010) Yiting Li et al.   CANCER

Osteosarcoma – conventional treatment vs. gene therapy

(2010) Mei Lin Tan et al.   CANCER BIOLOGY & THERAPY

Primary Osteogenic Sarcoma with Pulmonary Metastasis: Clinical Results and Prognostic Factors in 91 Patients

(2009) P. K. Wu et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Matrix Metalloproteinase 9 Is a Mediator of Epidermal Growth Factor-Dependent E-Cadherin Loss in Ovarian Carcinoma Cells

(2008) K. D. Cowden Dahl et al.   CANCER RESEARCH