Triggering the Resolution of Immune Mediated Inflammatory Diseases: Can Targeting Leukocyte Migration Be the Answer?

Novel Anti-Inflammatory Peptides Based on Chemokine–Glycosaminoglycan Interactions Reduce Leukocyte Migration and Disease Severity in a Model of Rheumatoid Arthritis

(2018) Emily F. McNaughton et al.   JOURNAL OF IMMUNOLOGY

The atypical chemokine receptor 2 limits renal inflammation and fibrosis in murine progressive immune complex glomerulonephritis

(2018) Andrei Bideak et al.   KIDNEY INTERNATIONAL

Leukocyte trafficking between stromal compartments: lessons from rheumatoid arthritis

(2018) Christopher D. Buckley et al.   Nature Reviews Rheumatology

Maresin 1 improves insulin sensitivity and attenuates adipose tissue inflammation in ob/ob and diet-induced obese mice

(2017) Leyre Martínez-Fernández et al.   FASEB JOURNAL

11β-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI

(2017) Katie J Mylonas et al.   JOURNAL OF ENDOCRINOLOGY

Monocyte Subsets Coregulate Inflammatory Responses by Integrated Signaling through TNF and IL-6 at the Endothelial Cell Interface

(2017) Myriam Chimen et al.   JOURNAL OF IMMUNOLOGY

Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P1) Agonists and Future Perspectives

(2017) Alaric J. Dyckman   JOURNAL OF MEDICINAL CHEMISTRY

Sphingosine-1-Phosphate Promotes the Persistence of Activated CD4 T Cells in Inflamed Sites

(2017) Shafqat Ahrar Jaigirdar et al.   Frontiers in Immunology

Endothelial Cell Junctional Adhesion Molecules

(2016) Natalia Reglero-Real et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

11β-Hydroxysteroid Dehydrogenase Type 1 Is Expressed in Neutrophils and Restrains an Inflammatory Response in Male Mice

(2016) Agnes E. Coutinho et al.   ENDOCRINOLOGY

Oral fingolimod in primary progressive multiple sclerosis (INFORMS): a phase 3, randomised, double-blind, placebo-controlled trial

(2016) Fred Lublin et al.   LANCET

Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells and endothelium and modulated during inflammatory bowel disease

(2016) T Karuppuchamy et al.   Mucosal Immunology

Resolution of inflammation: a new therapeutic frontier

(2016) James N. Fullerton et al.   NATURE REVIEWS DRUG DISCOVERY

Glucocorticoids and chronic inflammation

(2016) Rainer H. Straub et al.   RHEUMATOLOGY

Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity

(2016) G. L. Burn et al.   Science Signaling

Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity

(2016) G. L. Burn et al.   Science Signaling

Annexin A1 and the Resolution of Inflammation: Modulation of Neutrophil Recruitment, Apoptosis, and Clearance

(2016) Michelle Amantéa Sugimoto et al.   Journal of Immunology Research

Atypical Chemokine Receptors and Their Roles in the Resolution of the Inflammatory Response

(2016) Raffaella Bonecchi et al.   Frontiers in Immunology

Resolution of Inflammation: What Controls Its Onset?

(2016) Michelle A. Sugimoto et al.   Frontiers in Immunology

A6.6 Functional pathways in endothelial cells are differentially regulated by fibroblasts from patients with RA and resolving disease

(2015) HM McGettrick et al.   ANNALS OF THE RHEUMATIC DISEASES

Lipid mediators of inflammation in rheumatoid arthritis and osteoarthritis

(2015) Hilde Brouwers et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Targeting cell migration in rheumatoid arthritis

(2015) Darren L. Asquith et al.   CURRENT OPINION IN RHEUMATOLOGY

A Multihit Model

(2015) Lydia M. Keubler et al.   INFLAMMATORY BOWEL DISEASES

FTY720 Abrogates Collagen-Induced Arthritis by Hindering Dendritic Cell Migration to Local Lymph Nodes

(2015) Yanping Han et al.   JOURNAL OF IMMUNOLOGY

Homeostatic regulation of T cell trafficking by a B cell–derived peptide is impaired in autoimmune and chronic inflammatory disease

(2015) Myriam Chimen et al.   NATURE MEDICINE

The resolution of inflammation: Principles and challenges

(2015) Sarah E. Headland et al.   SEMINARS IN IMMUNOLOGY

Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin

(2015) Claudia Nussbaum et al.   Nature Communications

T cell migration in rheumatoid arthritis

(2015) Mario Mellado   Frontiers in Immunology

The Roles of Integrins in Function of Human Neutrophils after Their Migration through Endothelium into Interstitial Matrix

(2015) Ding Luo et al.   PLoS One

The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals

(2014) Rachel Bayley et al.   ANNALS OF THE RHEUMATIC DISEASES

Maresin 1 mitigates LPS-induced acute lung injury in mice

(2014) Jie Gong et al.   BRITISH JOURNAL OF PHARMACOLOGY

Leukocyte Migration into Inflamed Tissues

(2014) Sussan Nourshargh et al.   IMMUNITY

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

The Pro-Resolving Lipid Mediator Maresin 1 (MaR1) Attenuates Inflammatory Signaling Pathways in Vascular Smooth Muscle and Endothelial Cells

(2014) Anuran Chatterjee et al.   PLoS One

Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations

(2014) Graham K. Sheridan et al.   Scientific Reports

Resolution of inflammation: an integrated view

(2013) Almudena Ortega-Gómez et al.   EMBO Molecular Medicine

Fingolimod for the treatment of relapsing multiple sclerosis

(2013) Barry A Singer   Expert Review of Neurotherapeutics

11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis

(2013) Tiina Kipari et al.   FASEB JOURNAL

Maresin 1, a Proresolving Lipid Mediator Derived from Omega-3 Polyunsaturated Fatty Acids, Exerts Protective Actions in Murine Models of Colitis

(2013) R. Marcon et al.   JOURNAL OF IMMUNOLOGY

Annexin-A1 peptide down-regulates the leukocyte recruitment and up-regulates interleukin-10 release into lung after intestinal ischemia-reperfusion in mice

(2013) Bruna Candido Guido et al.   Journal of Inflammation-London

Leukocyte recruitment in the brain in sepsis: involvement of the annexin 1-FPR2/ALX anti-inflammatory system

(2012) Felicity N. E. Gavins et al.   FASEB JOURNAL

Tissue stroma as a regulator of leukocyte recruitment in inflammation

(2012) Helen M. McGettrick et al.   JOURNAL OF LEUKOCYTE BIOLOGY

11beta-Hydroxysteroid dehydrogenase type 1 inhibitors: novel agents for the treatment of metabolic syndrome and obesity-related disorders?

(2012) Panagiotis Anagnostis et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Resolvins and Protectins in Inflammation Resolution

(2011) Charles N. Serhan et al.   CHEMICAL REVIEWS

Novel Fat Depot-Specific Mechanisms Underlie Resistance to Visceral Obesity and Inflammation in 11 -Hydroxysteroid Dehydrogenase Type 1-Deficient Mice

(2011) M. Wamil et al.   DIABETES

11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice

(2011) Agnes E. Coutinho et al.   ENDOCRINOLOGY

Amelioration of Collagen-Induced Arthritis by a Novel S1P1 Antagonist with Immunomodulatory Activities

(2011) Y. Fujii et al.   JOURNAL OF IMMUNOLOGY

Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M

(2011) C. Christoffersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quiz Page June 2010

(2010) Prajwol Pant et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Improved heart function follows enhanced inflammatory cell recruitment and angiogenesis in 11βHSD1-deficient mice post-MI

(2010) Sara J. McSweeney et al.   CARDIOVASCULAR RESEARCH

Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model

(2010) Sachi Tsunemi et al.   CLINICAL IMMUNOLOGY

The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights

(2010) Agnes E. Coutinho et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Intrathecal increase of sphingosine 1-phosphate at early stage multiple sclerosis

(2010) Alina Kułakowska et al.   NEUROSCIENCE LETTERS

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

(2010) S. Krishnamoorthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibroblasts from different sites may promote or inhibit recruitment of flowing lymphocytes by endothelial cells

(2009) Helen M. McGettrick et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tristetraprolin Is Required for Full Anti-Inflammatory Response of Murine Macrophages to IL-10

(2009) B. Schaljo et al.   JOURNAL OF IMMUNOLOGY

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

(2009) Matthew Spite et al.   NATURE

Duffy antigen receptor for chemokines and CXCL5 are essential for the recruitment of neutrophils in a multicellular model of rheumatoid arthritis synovium

(2008) Emily Smith et al.   ARTHRITIS AND RHEUMATISM

Dexamethasone augments CXCR4-mediated signaling in resting human T cells via the activation of the Src kinase Lck

(2008) M. C. Ghosh et al.   BLOOD

Increased survival and reduced renal injury in MRL/lpr mice treated with a novel sphingosine-1-phosphate receptor agonist

(2008) Scott E. Wenderfer et al.   KIDNEY INTERNATIONAL

The role and regulation of 11β-hydroxysteroid dehydrogenase type 1 in the inflammatory response

(2008) Karen E. Chapman et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY