GRKs and β-Arrestins: “Gatekeepers” of Mitochondrial Function in the Failing Heart

Megalin mediates plasma membrane to mitochondria cross-talk and regulates mitochondrial metabolism

(2018) Qingtian Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation

(2018) Priscila Y. Sato et al.   Science Signaling

Regulation of cellular oxidative stress and apoptosis by G protein-coupled receptor kinase-2; The role of NADPH oxidase 4

(2016) Tiju Theccanat et al.   CELLULAR SIGNALLING

Mitochondrial Function, Biology, and Role in Disease

(2016) Elizabeth Murphy et al.   CIRCULATION RESEARCH

Adrenergic signaling in heart failure and cardiovascular aging

(2016) Gaetano Santulli et al.   MATURITAS

Correcting mitochondrial fusion by manipulating mitofusin conformations

(2016) Antonietta Franco et al.   NATURE

Mitochondrial Quality Control in Cardiac Diseases

(2016) Juliane C. Campos et al.   Frontiers in Physiology

The emerging roles of β-arrestins in fibrotic diseases

(2015) Yuan-jing Gu et al.   ACTA PHARMACOLOGICA SINICA

Impaired mitochondrial network excitability in failing guinea-pig cardiomyocytes

(2015) Kah Yong Goh et al.   CARDIOVASCULAR RESEARCH

How Mitochondrial Dynamism Orchestrates Mitophagy

(2015) O. S. Shirihai et al.   CIRCULATION RESEARCH

Regulation of mitochondrial oxidative stress by  -arrestins in cultured human cardiac fibroblasts

(2015) J. L. Philip et al.   Disease Models & Mechanisms

Mitochondrial dynamism and heart disease: changing shape and shaping change

(2015) G. W. Dorn   EMBO Molecular Medicine

Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity

(2015) Tetsuro Oda et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levels

(2015) Priscila Y. Sato et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy

(2015) Daniela Sorriento et al.   Journal of Cardiovascular Translational Research

Mitochondrial dynamics and mitochondrial quality control

(2015) Hong-Min Ni et al.   Redox Biology

Promoting PGC-1α-driven mitochondrial biogenesis is detrimental in pressure-overloaded mouse hearts

(2014) Georgios Karamanlidis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiac Mitochondria and Reactive Oxygen Species Generation

(2014) Yeong-Renn Chen et al.   CIRCULATION RESEARCH

GRK5-Mediated Exacerbation of Pathological Cardiac Hypertrophy Involves Facilitation of Nuclear NFAT Activity

(2014) Jonathan E. Hullmann et al.   CIRCULATION RESEARCH

G Protein–Coupled Receptor Kinase 2

(2014) Meryl C. Woodall et al.   CIRCULATION RESEARCH

Dual Modulation of the Mitochondrial Permeability Transition Pore and Redox Signaling Synergistically Promotes Cardiomyocyte Differentiation From Pluripotent Stem Cells

(2014) Sung Woo Cho et al.   Journal of the American Heart Association

Endothelial G Protein–Coupled Receptor Kinase 2 Regulates Vascular Homeostasis Through the Control of Free Radical Oxygen Species

(2013) Michele Ciccarelli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Caspase-cleaved arrestin-2 and BID cooperatively facilitate cytochrome C release and cell death

(2013) S Kook et al.   CELL DEATH AND DIFFERENTIATION

Prodeath Signaling of G Protein–Coupled Receptor Kinase 2 in Cardiac Myocytes After Ischemic Stress Occurs Via Extracellular Signal–Regulated Kinase-Dependent Heat Shock Protein 90–Mediated Mitochondrial Targeting

(2013) Mai Chen et al.   CIRCULATION RESEARCH

Role of β-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking

(2013) Dong Soo Kang et al.   CURRENT OPINION IN CELL BIOLOGY

Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages

(2013) D. Sorriento et al.   FEBS LETTERS

Interactions between sarco-endoplasmic reticulum and mitochondria in cardiac and skeletal muscle - pivotal roles in Ca2+ and reactive oxygen species signaling

(2013) V. Eisner et al.   JOURNAL OF CELL SCIENCE

Developmental and tumoral vascularization is regulated by G protein–coupled receptor kinase 2

(2013) Verónica Rivas et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial Fusion Directs Cardiomyocyte Differentiation via Calcineurin and Notch Signaling

(2013) A. Kasahara et al.   SCIENCE

Mitochondrial dynamics in the adult cardiomyocytes: which roles for a highly specialized cell?

(2013) Jerome Piquereau et al.   Frontiers in Physiology

Cardiac G-Protein–Coupled Receptor Kinase 2 Ablation Induces a Novel Ca 2+ Handling Phenotype Resistant to Adverse Alterations and Remodeling After Myocardial Infarction

(2012) Philip W. Raake et al.   CIRCULATION

Mitofusin 2-Containing Mitochondrial-Reticular Microdomains Direct Rapid Cardiomyocyte Bioenergetic Responses Via Interorganelle Ca 2+ Crosstalk

(2012) Yun Chen et al.   CIRCULATION RESEARCH

GRK2 Inhibition in Heart Failure: Something Old, Something New

(2012) Anastasios Lymperopoulos et al.   CURRENT PHARMACEUTICAL DESIGN

SR and mitochondria: Calcium cross-talk between kissing cousins

(2012) Gerald W. Dorn et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondria: master regulators of danger signalling

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bax regulates primary necrosis through mitochondrial dynamics

(2012) R. S. Whelan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GRK2: multiple roles beyond G protein-coupled receptor desensitization

(2012) Tama Evron et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Oxidative stress and heart failure

(2011) Hiroyuki Tsutsui et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

(2011) Tohru Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

Cardiac mitochondria in heart failure: Normal cardiolipin profile and increased threonine phosphorylation of complex IV

(2011) Mariana Rosca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis

(2011) Anna Fusco et al.   CELLULAR SIGNALLING

G Protein–Coupled Receptor Kinase 2 Activity Impairs Cardiac Glucose Uptake and Promotes Insulin Resistance After Myocardial Ischemia

(2011) Michele Ciccarelli et al.   CIRCULATION

Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart

(2011) Hélène Lemieux et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cellular mechanisms of cardiomyopathy

(2011) Pamela A. Harvey et al.   JOURNAL OF CELL BIOLOGY

Communication between mitochondria and nucleus: Putative role for VDAC in reduction/oxidation mechanism

(2010) Hanna Galganska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets

(2010) Petronila Penela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

(2010) Sang-Bing Ong et al.   CIRCULATION

Level of G protein–Coupled Receptor Kinase-2 Determines Myocardial Ischemia/Reperfusion Injury via Pro- and Anti-Apoptotic Mechanisms

(2010) Henriette Brinks et al.   CIRCULATION RESEARCH

Mitochondrial Pruning by Nix and BNip3: An Essential Function for Cardiac-Expressed Death Factors

(2010) Gerald W. Dorn   Journal of Cardiovascular Translational Research

The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance

(2009) Ersilia Cipolletta et al.   CARDIOVASCULAR RESEARCH

β-Arrestins facilitate ubiquitin-dependent degradation of apoptosis signal-regulating kinase 1 (ASK1) and attenuate H2O2-induced apoptosis

(2009) Zhengping Zhang et al.   CELLULAR SIGNALLING

Cross-talk between L-type Ca2+channels and mitochondria

(2009) Helena M Viola et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Dynamic organization of mitochondria in human heart and in myocardial disease

(2009) Charles L. Hoppel et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cardiac reanimation: targeting cardiomyocyte death by BNIP3 and NIX/BNIP3L

(2009) G W Dorn et al.   ONCOGENE

Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation

(2008) Mariana G. Rosca et al.   CARDIOVASCULAR RESEARCH

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY