Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy

Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns

(2014) Elisa Lucas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

GRK5-Mediated Exacerbation of Pathological Cardiac Hypertrophy Involves Facilitation of Nuclear NFAT Activity

(2014) Jonathan E. Hullmann et al.   CIRCULATION RESEARCH

G Protein–Coupled Receptor Kinase 2

(2014) Meryl C. Woodall et al.   CIRCULATION RESEARCH

Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages

(2013) D. Sorriento et al.   FEBS LETTERS

Cardiac G-Protein–Coupled Receptor Kinase 2 Ablation Induces a Novel Ca 2+ Handling Phenotype Resistant to Adverse Alterations and Remodeling After Myocardial Infarction

(2012) Philip W. Raake et al.   CIRCULATION

Interleukin-10 Treatment Attenuates Pressure Overload–Induced Hypertrophic Remodeling and Improves Heart Function via Signal Transducers and Activators of Transcription 3–Dependent Inhibition of Nuclear Factor-κB

(2012) Suresh Kumar Verma et al.   CIRCULATION

AAV6. ARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model

(2012) P. W. J. Raake et al.   EUROPEAN HEART JOURNAL

Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis

(2011) Anna Fusco et al.   CELLULAR SIGNALLING

G Protein–Coupled Receptor Kinase 2 Activity Impairs Cardiac Glucose Uptake and Promotes Insulin Resistance After Myocardial Ischemia

(2011) Michele Ciccarelli et al.   CIRCULATION

Towards a re-definition of ‘cardiac hypertrophy’ through a rational characterization of left ventricular phenotypes: a position paper of the Working Group ‘Myocardial Function’ of the ESC

(2011) Ralph Knöll et al.   EUROPEAN JOURNAL OF HEART FAILURE

Intracardiac Injection of AdGRK5-NT Reduces Left Ventricular Hypertrophy by Inhibiting NF-κB–Dependent Hypertrophic Gene Expression

(2010) Daniela Sorriento et al.   HYPERTENSION

The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro

(2010) Sarah J. Watkins et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

G-protein-coupled-receptor kinases mediate TNFα-induced NF-κB signalling via direct interaction with and phosphorylation of IκBα

(2009) Sonika Patial et al.   BIOCHEMICAL JOURNAL

The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance

(2009) Ersilia Cipolletta et al.   CARDIOVASCULAR RESEARCH

Fenofibrate inhibits adipocyte hypertrophy and insulin resistance by activating adipose PPARα in high fat diet-induced obese mice

(2009) Sunhyo Jeong et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity

(2009) Daniela Sorriento et al.   Molecular Cancer

G Protein–Coupled Receptor Kinase 2 Ablation in Cardiac Myocytes Before or After Myocardial Infarction Prevents Heart Failure

(2008) Philip W. Raake et al.   CIRCULATION RESEARCH

The G-protein-coupled receptor kinase 5 inhibits NF B transcriptional activity by inducing nuclear accumulation of I B 

(2008) D. Sorriento et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA