Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways

Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway

(2018) Xisong Wang et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Iron overload induces G1 phase arrest and autophagy in murine preosteoblast cells

(2018) Wan-Jing Cen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Icariin modulates mitochondrial function and apoptosis in high glucose-induced glomerular podocytes through G protein-coupled estrogen receptors

(2018) Chen Qiao et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A cardiac glycoside HTF-1 isolated from Helleborus thibetanus Franch displays potent in vitro anti-cancer activity via caspase-9, MAPK and PI3K-Akt-mTOR pathways

(2018) Long Ma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The role of triiodothyronine hormone and mechanically-stressed endothelial cell paracrine signalling synergism in gene reprogramming during hBMSC-stimulated osteogenic phenotype in vitro

(2018) Rodrigo A. da Silva et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Icariin Promotes the Migration of BMSCs In Vitro and In Vivo via the MAPK Signaling Pathway

(2018) Feng Jiao et al.   Stem Cells International

Exosomes Derived From Mesenchymal Stromal Cells Pretreated With Advanced Glycation End Product-Bovine Serum Albumin Inhibit Calcification of Vascular Smooth Muscle Cells

(2018) Ying Wang et al.   Frontiers in Endocrinology

Intra-articular implantation of autologous bone marrow–derived mesenchymal stromal cells to treat knee osteoarthritis: a randomized, triple-blind, placebo-controlled phase 1/2 clinical trial

(2018) MOHSEN EMADEDIN et al.   CYTOTHERAPY

Long noncoding RNA Plnc1 controls adipocyte differentiation by regulating peroxisome proliferator–activated receptor γ

(2018) Endong Zhu et al.   FASEB JOURNAL

Protective Effects of L-3-n-Butylphthalide Against H2O2-Induced Injury in Neural Stem Cells by Activation of PI3K/Akt and Mash1 Pathway

(2018) Shan Wang et al.   NEUROSCIENCE

The mechanisms of systemic iron homeostasis and etiology, diagnosis, and treatment of hereditary hemochromatosis

(2017) Hiroshi Kawabata   INTERNATIONAL JOURNAL OF HEMATOLOGY

The Combination of icariin and constrained dynamic loading stimulation attenuates bone loss in ovariectomy-induced osteoporotic mice

(2017) Qiang-Song Wang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Melatonin protects bone marrow mesenchymal stem cells against iron overload-induced aberrant differentiation and senescence

(2017) Fan Yang et al.   JOURNAL OF PINEAL RESEARCH

Iron overload promotes erythroid apoptosis through regulating HIF-1a/ROS signaling pathway in patients with myelodysplastic syndrome

(2017) Qing-qing Zheng et al.   LEUKEMIA RESEARCH

The effect of icariin on bone metabolism and its potential clinical application

(2017) Z. Wang et al.   OSTEOPOROSIS INTERNATIONAL

Mff‐Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS‐Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation‐Involved mPTP Opening

(2017) Hao Zhou et al.   Journal of the American Heart Association

Icariin promotes osteogenic differentiation of rat bone marrow stromal cells by activating the ERα-Wnt/β-catenin signaling pathway

(2016) QiuShi Wei et al.   BIOMEDICINE & PHARMACOTHERAPY

Overexpression of HSPA1A enhances the osteogenic differentiation of bone marrow mesenchymal stem cells via activation of the Wnt/β-catenin signaling pathway

(2016) Wei Zhang et al.   Scientific Reports

Icariin Promotes Angiogenic Differentiation and Prevents Oxidative Stress-Induced Autophagy in Endothelial Progenitor Cells

(2015) Yubo Tang et al.   STEM CELLS

Effects of Iron Overload on the Bone Marrow Microenvironment in Mice

(2015) Yuchen Zhang et al.   PLoS One

The effect of type II collagen on MSC osteogenic differentiation and bone defect repair

(2014) Li-Hsuan Chiu et al.   BIOMATERIALS

Icariin attenuates hypoxia-induced oxidative stress and apoptosis in osteoblasts and preserves their osteogenic differentiation potentialin vitro

(2014) H.-P. Ma et al.   CELL PROLIFERATION

Terbium promotes adhesion and osteogenic differentiation of mesenchymal stem cells via activation of the Smad-dependent TGF-β/BMP signaling pathway

(2014) Dan-Dan Liu et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Longitudinal analysis of heart and liver iron in thalassemia major patients according to chelation treatment

(2013) F. Danjou et al.   BLOOD CELLS MOLECULES AND DISEASES

Asiatic Acid Inhibits Adipogenic Differentiation of Bone Marrow Stromal Cells

(2013) Zheng-Wei Li et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Enhanced Phosphatidylinositol 3-kinase (PI3K)/Akt Signaling Has Pleiotropic Targets in Hippocampal Neurons Exposed to Iron-induced Oxidative Stress

(2013) Romina María Uranga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Comparative study of the osteogenic differentiation capacity of human bone marrow- and human adipose-derived stem cells under cyclic tensile stretch using quantitative analysis

(2012) YAPING YE et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Iron homeostasis in osteoporosis and its clinical implications

(2012) G. F. Li et al.   OSTEOPOROSIS INTERNATIONAL

Expression of Survivin, Bcl-2 and Bax Proteins in the Domestic Cat (Felis catus) Endometrium During the Oestrus Cycle

(2012) N Liman et al.   REPRODUCTION IN DOMESTIC ANIMALS

Bone disease in adult patients with β-thalassaemia major: a case–control study

(2011) Marina Baldini et al.   Internal and Emergency Medicine

Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases

(2010) P. Hemachandra Reddy et al.   BRAIN RESEARCH REVIEWS

Mechanisms involved in the therapeutic properties of mesenchymal stem cells

(2009) Lindolfo da Silva Meirelles et al.   CYTOKINE & GROWTH FACTOR REVIEWS

From Mice to Men

(2009) Marc S. Penn et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Adipogénesis y osteoporosis

(2009) Juan Pablo Rodríguez et al.   REVISTA MEDICA DE CHILE

Role of iron metabolism and oxidative damage in postmenopausal bone loss

(2008) Patrizia D'Amelio et al.   BONE

Japanese epidemiological survey with consensus statement on Japanese guidelines for treatment of iron overload in bone marrow failure syndromes

(2008) Takahiro Suzuki et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Association between iron overload and osteoporosis in patients with hereditary hemochromatosis

(2008) L. Valenti et al.   OSTEOPOROSIS INTERNATIONAL