Icariin Attenuates M1 Activation of Microglia and Aβ Plaque Accumulation in the Hippocampus and Prefrontal Cortex by Up-Regulating PPARγ in Restraint/Isolation-Stressed APP/PS1 Mice

Microglia Polarization and Endoplasmic Reticulum Stress in Chronic Social Defeat Stress Induced Depression Mouse

(2018) Jie Tang et al.   NEUROCHEMICAL RESEARCH

Stress Hormone Leads to Memory Deficits and Altered Tau Phosphorylation in a Model of Alzheimer's Disease

(2018) Yash B. Joshi et al.   JOURNAL OF ALZHEIMERS DISEASE

Switching of the Microglial Activation Phenotype Is a Possible Treatment for Depression Disorder

(2018) Lijuan Zhang et al.   Frontiers in Cellular Neuroscience

Stress-altered synaptic plasticity and DAMP signaling in the hippocampus-PFC axis; elucidating the significance of IGF-1/IGF-1R/CaMKIIα expression in neural changes associated with a prolonged exposure therapy

(2017) Olalekan M. Ogundele et al.   NEUROSCIENCE

Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: the emerging role for microglia?

(2017) Sami Piirainen et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Adiponectin Regulates the Polarization and Function of Microglia via PPAR-γ Signaling Under Amyloid β Toxicity

(2017) Juhyun Song et al.   Frontiers in Cellular Neuroscience

Chronic Depressive Symptomatology in Mild Cognitive Impairment Is Associated with Frontal Atrophy Rate which Hastens Conversion to Alzheimer Dementia

(2016) Simona Sacuiu et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Immunotherapeutic effects of lymphocytes co-cultured with human cord blood-derived multipotent stem cells transplantation on APP/PS1 mice

(2016) Yi He et al.   BEHAVIOURAL BRAIN RESEARCH

Icariin attenuates cerebral ischemia–reperfusion injury through inhibition of inflammatory response mediated by NF-κB, PPARα and PPARγ in rats

(2016) Deqing Xiong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPARγ-mediated alteration of microglial activation phenotypes

(2016) Qiuying Zhao et al.   Journal of Neuroinflammation

Genetic Deletion of Neuronal PPARγ Enhances the Emotional Response to Acute Stress and Exacerbates Anxiety: An Effect Reversed by Rescue of Amygdala PPARγ Function

(2016) Esi Domi et al.   JOURNAL OF NEUROSCIENCE

Role of the adipose PPARγ-adiponectin axis in susceptibility to stress and depression/anxiety-related behaviors

(2016) M Guo et al.   MOLECULAR PSYCHIATRY

Depression and Incident Alzheimer Disease: The Impact of Disease Severity

(2015) Patricia Gracia-García et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Posttraumatic Stress Disorder-Like Induction Elevates  -Amyloid Levels, Which Directly Activates Corticotropin-Releasing Factor Neurons to Exacerbate Stress Responses

(2015) N. J. Justice et al.   JOURNAL OF NEUROSCIENCE

Icariin decreases both APP and Aβ levels and increases neurogenesis in the brain of Tg2576 mice

(2015) F. Li et al.   NEUROSCIENCE

Icariin exerts an antidepressant effect in an unpredictable chronic mild stress model of depression in rats and is associated with the regulation of hippocampal neuroinflammation

(2015) B. Liu et al.   NEUROSCIENCE

Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways

(2015) Junghyung Park et al.   NEUROSCIENCE LETTERS

Phenotypic dysregulation of microglial activation in young offspring rats with maternal sleep deprivation-induced cognitive impairment

(2015) Qiuying Zhao et al.   Scientific Reports

Icariin, a phoshphodiesterase-5 inhibitor, improves learning and memory in APP/PS1 transgenic mice by stimulation of NO/cGMP signalling

(2014) Feng Jin et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Icariin promotes histone acetylation and attenuates post-stroke cognitive impairment in the central cholinergic circuits of mice

(2013) X. Wang et al.   NEUROSCIENCE

Minocycline selectively inhibits M1 polarization of microglia

(2013) K Kobayashi et al.   Cell Death & Disease

An Update of Animal Models of Alzheimer Disease with a Reevaluation of Plaque Depositions

(2013) Jung-Eun Lee et al.   Experimental Neurobiology

Regulation of microglia activation and deactivation by nuclear receptors

(2012) Kaoru Saijo et al.   GLIA

PPAR /RXR -Induced and CD36-Mediated Microglial Amyloid-  Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice

(2012) M. Yamanaka et al.   JOURNAL OF NEUROSCIENCE

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Effects of different adrenergic blockades on the stress resistance of Wistar rats

(2012) Le Jin Yang et al.   NEUROSCIENCE LETTERS

Human Atherosclerotic Plaque Alternative Macrophages Display Low Cholesterol Handling but High Phagocytosis Because of Distinct Activities of the PPARγ and LXRα Pathways

(2011) Giulia Chinetti-Gbaguidi et al.   CIRCULATION RESEARCH

Icariin and its derivative, ICT, exert anti-inflammatory, anti-tumor effects, and modulate myeloid derived suppressive cells (MDSCs) functions

(2011) Junmin Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Chronic Stress Exacerbates Tau Pathology, Neurodegeneration, and Cognitive Performance through a Corticotropin-Releasing Factor Receptor-Dependent Mechanism in a Transgenic Mouse Model of Tauopathy

(2011) J. C. Carroll et al.   JOURNAL OF NEUROSCIENCE

Posttraumatic Stress Disorder and Risk of Dementia Among US Veterans

(2010) Kristine Yaffe et al.   ARCHIVES OF GENERAL PSYCHIATRY

Control of Macrophage Activation and Function by PPARs

(2010) Ajay Chawla   CIRCULATION RESEARCH

Greater Prevalence and Incidence of Dementia in Older Veterans with Posttraumatic Stress Disorder

(2010) Salah U. Qureshi et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Swimming exercise effects on the expression of HSP70 and iNOS in hippocampus and prefrontal cortex in combined stress

(2010) Xin Liu et al.   NEUROSCIENCE LETTERS

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats

(2010) Fei Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Protective effects of icariin on brain dysfunction induced by lipopolysaccharide in rats

(2010) J. Guo et al.   PHYTOMEDICINE

The glucocorticoid receptor: Pivot of depression and of antidepressant treatment?

(2010) Christoph Anacker et al.   PSYCHONEUROENDOCRINOLOGY

Icariin inhibits beta-amyloid peptide segment 25–35 induced expression of β-secretase in rat hippocampus

(2009) Jing Nie et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β

(2009) Alessandro Michelucci et al.   JOURNAL OF NEUROIMMUNOLOGY

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau

(2008) Ioannis Sotiropoulos et al.   JOURNAL OF NEUROCHEMISTRY