Mysteries in embryonic development: How can errors arise so frequently at the beginning of mammalian life?

Efficient generation of targeted large insertions by microinjection into two-cell-stage mouse embryos

(2018) Bin Gu et al.   NATURE BIOTECHNOLOGY

P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development

(2018) Sarah Bowling et al.   Nature Communications

A novel atypical sperm centriole is functional during human fertilization

(2018) Emily L. Fishman et al.   Nature Communications

Dual-spindle formation in zygotes keeps parental genomes apart in early mammalian embryos

(2018) Judith Reichmann et al.   SCIENCE

Mitotic spindle disruption in human preimplantation embryos activates the spindle assembly checkpoint but not apoptosis until Day 5 of development

(2017) K. Jacobs et al.   MOLECULAR HUMAN REPRODUCTION

A single trophectoderm biopsy at blastocyst stage is mathematically unable to determine embryo ploidy accurately enough for clinical use

(2017) Norbert Gleicher et al.   Reproductive Biology and Endocrinology

Delayed APC/C activation extends the first mitosis of mouse embryos

(2017) Anna Ajduk et al.   Scientific Reports

Positive Feedback Keeps Duration of Mitosis Temporally Insulated from Upstream Cell-Cycle Events

(2016) Ana Rita Araujo et al.   MOLECULAR CELL

Micronucleus formation causes perpetual unilateral chromosome inheritance in mouse embryos

(2016) Cayetana Vázquez-Diez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accuracy of preimplantation genetic screening (PGS) is compromised by degree of mosaicism of human embryos

(2016) Norbert Gleicher et al.   Reproductive Biology and Endocrinology

F-actin mechanics control spindle centring in the mouse zygote

(2016) Agathe Chaigne et al.   Nature Communications

Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential

(2016) Helen Bolton et al.   Nature Communications

A meiotic mystery: How sister kinetochores avoid being pulled in opposite directions during the first division

(2015) Kim Nasmyth   BIOESSAYS

Inherent Instability of Correct Kinetochore-Microtubule Attachments during Meiosis I in Oocytes

(2015) Shuhei Yoshida et al.   DEVELOPMENTAL CELL

Inverted light-sheet microscope for imaging mouse pre-implantation development

(2015) Petr Strnad et al.   NATURE METHODS

Healthy Babies after Intrauterine Transfer of Mosaic Aneuploid Blastocysts

(2015) Ermanno Greco et al.   NEW ENGLAND JOURNAL OF MEDICINE

Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytes

(2015) Z. Holubcova et al.   SCIENCE

Bivalent separation into univalents precedes age-related meiosis I errors in oocytes

(2015) Yogo Sakakibara et al.   Nature Communications

Sister kinetochore splitting and precocious disintegration of bivalents could explain the maternal age effect

(2015) Agata P Zielinska et al.   eLife

Single cell sequencing reveals low levels of aneuploidy across mammalian tissues

(2014) Kristin A. Knouse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased CDK1 activity determines the timing of kinetochore-microtubule attachments in meiosis I

(2013) Olga Davydenko et al.   JOURNAL OF CELL BIOLOGY

Cyclin B1 mRNA translation is temporally controlled through formation and disassembly of RNA granules

(2013) Tomoya Kotani et al.   JOURNAL OF CELL BIOLOGY

Cell cycle control across the eukaryotic kingdom

(2013) Hirofumi Harashima et al.   TRENDS IN CELL BIOLOGY

Molecular origin of mitotic aneuploidies in preimplantation embryos

(2012) Eleni Mantikou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Maturation of the kinetochore-microtubule interface and the meaning of metaphase

(2012) António J. Pereira et al.   CHROMOSOME RESEARCH

Spindle assembly checkpoint signalling is uncoupled from chromosomal position in mouse oocytes

(2012) L. Gui et al.   DEVELOPMENT

Timing of anaphase-promoting complex activation in mouse oocytes is predicted by microtubule-kinetochore attachment but not by bivalent alignment or tension

(2012) S. I. R. Lane et al.   DEVELOPMENT

The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development

(2012) Aurélien Courtois et al.   JOURNAL OF CELL BIOLOGY

Human aneuploidy: mechanisms and new insights into an age-old problem

(2012) So I. Nagaoka et al.   NATURE REVIEWS GENETICS

Geometry and force behind kinetochore orientation: lessons from meiosis

(2012) Yoshinori Watanabe   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension

(2012) A. Kolano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developmental Plasticity Is Bound by Pluripotency and the Fgf and Wnt Signaling Pathways

(2012) Samantha A. Morris et al.   Cell Reports

Complete Kinetochore Tracking Reveals Error-Prone Homologous Chromosome Biorientation in Mammalian Oocytes

(2011) Tomoya S. Kitajima et al.   CELL

Spindle Assembly Checkpoint Regulates Mitotic Cell Cycle Progression during Preimplantation Embryo Development

(2011) Yanchang Wei et al.   PLoS One

A Single Bivalent Efficiently Inhibits Cyclin B1 Degradation and Polar Body Extrusion in Mouse Oocytes Indicating Robust SAC during Female Meiosis I

(2011) Steffen Hoffmann et al.   PLoS One

Regulation of APC/C Activity in Oocytes by a Bub1-Dependent Spindle Assembly Checkpoint

(2009) Barry E. McGuinness et al.   CURRENT BIOLOGY

A shift from kinesin 5-dependent metaphase spindle function during preimplantation development in mouse

(2009) G. FitzHarris   DEVELOPMENT

The role of centrosomes in mammalian fertilization and its significance for ICSI

(2009) H. Schatten et al.   MOLECULAR HUMAN REPRODUCTION

Transitioning from egg to embryo: Triggers and mechanisms of egg activation

(2008) Vanessa L. Horner et al.   DEVELOPMENTAL DYNAMICS

Temporal regulation of embryonic M-phases.

(2008) Jacek Z Kubiak et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Temporal regulation of the first mitosis in Xenopus and mouse embryos

(2007) Jacek Z. Kubiak et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY