Mitotic spindle disruption in human preimplantation embryos activates the spindle assembly checkpoint but not apoptosis until Day 5 of development

Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential

(2016) Helen Bolton et al.   Nature Communications

Prediction model for aneuploidy in early human embryo development revealed by single-cell analysis

(2015) Maria Vera-Rodriguez et al.   Nature Communications

Signalling dynamics in the spindle checkpoint response

(2014) Nitobe London et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Array comparative genomic hybridization analyses of all blastomeres of a cohort of embryos from young IVF patients revealed significant contribution of mitotic errors to embryo mosaicism at the cleavage stage

(2014) Judy FC Chow et al.   Reproductive Biology and Endocrinology

Subcellular dynamics of the maternal cell death regulator BCL2L10 in human preimplantation embryos

(2013) Jean-François Guérin et al.   HUMAN REPRODUCTION

Evolution of aneuploidy up to Day 4 of human preimplantation development

(2013) A. Mertzanidou et al.   HUMAN REPRODUCTION

Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells

(2013) Liying Yan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular origin of mitotic aneuploidies in preimplantation embryos

(2012) Eleni Mantikou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Spindle Assembly Checkpoint

(2012) Pablo Lara-Gonzalez et al.   CURRENT BIOLOGY

Microarray analysis reveals abnormal chromosomal complements in over 70% of 14 normally developing human embryos

(2012) A. Mertzanidou et al.   HUMAN REPRODUCTION

The spindle-assembly checkpoint and the beauty of self-destruction

(2012) Andrea Musacchio et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage

(2012) Shawn L. Chavez et al.   Nature Communications

Aneuploidy in the Human Blastocyst

(2011) E. Fragouli et al.   CYTOGENETIC AND GENOME RESEARCH

The Human Cleavage Stage Embryo Is a Cradle of Chromosomal Rearrangements

(2011) T. Voet et al.   CYTOGENETIC AND GENOME RESEARCH

Fragmentation of embryos is associated with both necrosis and apoptosis

(2011) Hee-Jun Chi et al.   FERTILITY AND STERILITY

Cytoskeletal analysis of human blastocysts by confocal laser scanning microscopy following vitrification

(2011) K. Chatzimeletiou et al.   HUMAN REPRODUCTION

Spindle Assembly Checkpoint Regulates Mitotic Cell Cycle Progression during Preimplantation Embryo Development

(2011) Yanchang Wei et al.   PLoS One

Involvement of BCL2 family members in the regulation of human oocyte and early embryo survival and death: gene expression and beyond

(2011) Imene Boumela et al.   REPRODUCTION

Stalling in mitosis and releasing the apoptotic brake

(2010) Manabu Kurokawa et al.   EMBO JOURNAL

Phosphorylation of Mcl-1 by CDK1–cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest

(2010) Margaret E Harley et al.   EMBO JOURNAL

The fate of the mosaic embryo: chromosomal constitution and development of Day 4, 5 and 8 human embryos

(2010) Margarida Avo Santos et al.   HUMAN REPRODUCTION

Cytogenetic analysis of human blastocysts with the use of FISH, CGH and aCGH: scientific data and technical evaluation

(2010) E. Fragouli et al.   HUMAN REPRODUCTION

Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage

(2010) Connie C Wong et al.   NATURE BIOTECHNOLOGY

Impact of cleavage-stage embryo biopsy in view of PGD on human blastocyst implantation: a prospective cohort of single embryo transfers

(2009) A. De Vos et al.   HUMAN REPRODUCTION

Cyclin-Dependent Kinase 1-Mediated Bcl-xL/Bcl-2 Phosphorylation Acts as a Functional Link Coupling Mitotic Arrest and Apoptosis

(2009) D. T. Terrano et al.   MOLECULAR AND CELLULAR BIOLOGY

Chromosome instability is common in human cleavage-stage embryos

(2009) Evelyne Vanneste et al.   NATURE MEDICINE

Diagnostic efficiency, embryonic development and clinical outcome after the biopsy of one or two blastomeres for preimplantation genetic diagnosis

(2007) V. Goossens et al.   HUMAN REPRODUCTION