Anti-microRNA screen uncovers miR-17 family within miR-17~92 cluster as the primary driver of kidney cyst growth

Genome-wide association study identifies novel susceptible loci and highlights Wnt/beta-catenin pathway in the development of adolescent idiopathic scoliosis

(2017) Zezhang Zhu et al.   HUMAN MOLECULAR GENETICS

Lipid Nanoparticle–Mediated Delivery of Anti-miR-17 Family Oligonucleotide Suppresses Hepatocellular Carcinoma Growth

(2017) Xinqiang Huang et al.   MOLECULAR CANCER THERAPEUTICS

microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism

(2017) Sachin Hajarnis et al.   Nature Communications

Anti-miR-17 therapy delays tumorigenesis in MYC-driven hepatocellular carcinoma (HCC)

(2017) Renumathy Dhanasekaran et al.   Oncotarget

MicroRNA-21 Aggravates Cyst Growth in a Model of Polycystic Kidney Disease

(2015) R. Lakhia et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

An allelic series of miR-17∼92–mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron

(2015) Yoon-Chi Han et al.   NATURE GENETICS

Anti–microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways

(2014) Ivan G. Gomez et al.   JOURNAL OF CLINICAL INVESTIGATION

Making new contacts: the mTOR network in metabolism and signalling crosstalk

(2014) Mitsugu Shimobayashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MicroRNAs and their applications in kidney diseases

(2014) Shawn S. Badal et al.   PEDIATRIC NEPHROLOGY

Silencing of the miR-17 92 Cluster Family Inhibits Medulloblastoma Progression

(2013) B. L. Murphy et al.   CANCER RESEARCH

The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease

(2013) E Mogilyansky et al.   CELL DEATH AND DIFFERENTIATION

Macrophages promote polycystic kidney disease progression

(2013) Katherine I Swenson-Fields et al.   KIDNEY INTERNATIONAL

Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy

(2013) Isaline Rowe et al.   NATURE MEDICINE

miR-17 92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease

(2013) V. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-92b regulates the development of intermediate cortical progenitors in embryonic mouse brain

(2013) T. J. Nowakowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivering the promise of miRNA cancer therapeutics

(2012) Diane M. Pereira et al.   DRUG DISCOVERY TODAY

Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity

(2012) Katharina Hopp et al.   JOURNAL OF CLINICAL INVESTIGATION

Pri-miR-17-92a transcript folds into a tertiary structure and autoregulates its processing

(2012) S. Chakraborty et al.   RNA

Glucocorticoid-Mediated Repression of the Oncogenic microRNA Cluster miR-17∼92 Contributes to the Induction of Bim and Initiation of Apoptosis

(2011) Jason K. Molitoris et al.   MOLECULAR ENDOCRINOLOGY

Germline deletion of the miR-17∼92 cluster causes skeletal and growth defects in humans

(2011) Loïc de Pontual et al.   NATURE GENETICS

Silencing of microRNA families by seed-targeting tiny LNAs

(2011) Susanna Obad et al.   NATURE GENETICS

Role of pri-miRNA tertiary structure in miR-17~92 miRNA biogenesis

(2011) Steven G Chaulk et al.   RNA Biology

Mitochondrial ATP synthase deficiency due to a mutation in the ATP5E gene for the F1   subunit

(2010) J. A. Mayr et al.   HUMAN MOLECULAR GENETICS

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Advances in the pathogenesis and treatment of polycystic kidney disease

(2009) Vishal Patel et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

miR-19 is a key oncogenic component of mir-17-92

(2009) V. Olive et al.   GENES & DEVELOPMENT

Direct control of mitochondrial function by mTOR

(2009) Arvind Ramanathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NDUFA2 Complex I Mutation Leads to Leigh Disease

(2008) Saskia J.G. Hoefs et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Polycystic Kidney Disease

(2008) Peter C. Harris et al.   Annual Review of Medicine

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

(2008) C. Ling et al.   DIABETOLOGIA

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

(2008) Ulrike Burk et al.   EMBO REPORTS