miR-17 92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease

MicroRNAs in Stress Signaling and Human Disease

(2012) Joshua T. Mendell et al.   CELL

MicroRNAs and fibrosis

(2012) Vishal Patel et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity

(2012) Katharina Hopp et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNAs Regulate Renal Tubule Maturation through Modulation of Pkd1

(2012) V. Patel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Synthetic lethality between Rb, p53 and Dicer or miR-17–92 in retinal progenitors suppresses retinoblastoma formation

(2012) David Nittner et al.   NATURE CELL BIOLOGY

Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease

(2011) Priyanka Pandey et al.   BMC Systems Biology

miR-17 92 cooperates with RB pathway mutations to promote retinoblastoma

(2011) K. Conkrite et al.   GENES & DEVELOPMENT

Mutations in Multiple PKD Genes May Explain Early and Severe Polycystic Kidney Disease

(2011) C. Bergmann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A missense mutation in PKD1 attenuates the severity of renal disease

(2011) York Pei et al.   KIDNEY INTERNATIONAL

Pervasive roles of microRNAs in cardiovascular biology

(2011) Eric M. Small et al.   NATURE

A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation

(2011) Sorin V Fedeles et al.   NATURE GENETICS

The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity

(2010) U. Tran et al.   DEVELOPMENT

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Advances in the pathogenesis and treatment of polycystic kidney disease

(2009) Vishal Patel et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Loss of Oriented Cell Division Does not Initiate Cyst Formation

(2009) S. Nishio et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Incompletely penetrant PKD1 alleles suggest a role for gene dosage in cyst initiation in polycystic kidney disease

(2009) Sandro Rossetti et al.   KIDNEY INTERNATIONAL

MicroRNA-17 post-transcriptionally regulates polycystic kidney disease-2 gene and promotes cell proliferation

(2009) Huan Sun et al.   MOLECULAR BIOLOGY REPORTS

A mitotic transcriptional switch in polycystic kidney disease

(2009) Francisco Verdeguer et al.   NATURE MEDICINE

Polycystic Kidney Disease

(2008) Peter C. Harris et al.   Annual Review of Medicine

Microarray-based approach identifies microRNAs and their target functional patterns in polycystic kidney disease

(2008) Priyanka Pandey et al.   BMC GENOMICS

miRiad Roles for the miR-17-92 Cluster in Development and Disease

(2008) Joshua T. Mendell   CELL

Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters

(2008) Andrea Ventura et al.   CELL

Toward MicroRNA–Based Therapeutics for Heart Disease

(2008) Eva van Rooij et al.   CIRCULATION RESEARCH

Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia

(2008) Vishal Patel et al.   HUMAN MOLECULAR GENETICS

Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1

(2008) Sekiya Shibazaki et al.   HUMAN MOLECULAR GENETICS

Fibrocystin/Polyductin Modulates Renal Tubular Formation by Regulating Polycystin-2 Expression and Function

(2008) I. Kim et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

(2008) Changchun Xiao et al.   NATURE IMMUNOLOGY

Kidney cysts, pancreatic cysts, and biliary disease in a mouse model of autosomal recessive polycystic kidney disease

(2008) Scott S. Williams et al.   PEDIATRIC NEPHROLOGY

The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition

(2008) Nicole Cloonan et al.   GENOME BIOLOGY