The evolution of S100B inhibitors for the treatment of malignant melanoma

Serum markers lactate dehydrogenase and S100B predict independently disease outcome in melanoma patients with distant metastasis

(2012) B Weide et al.   BRITISH JOURNAL OF CANCER

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Balancing target flexibility and target denaturation in computational fragment-based inhibitor discovery

(2012) Theresa J. Foster et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Target Binding to S100B Reduces Dynamic Properties and Increases Ca2+-Binding Affinity for Wild Type and EF-Hand Mutant Proteins

(2012) Melissa A. Liriano et al.   JOURNAL OF MOLECULAR BIOLOGY

Ipilimumab in advanced melanoma

(2012) Alberto Farolfi et al.   MELANOMA RESEARCH

Combinations of BRAF, MEK, and PI3K/mTOR Inhibitors Overcome Acquired Resistance to the BRAF Inhibitor GSK2118436 Dabrafenib, Mediated by NRAS or MEK Mutations

(2012) J. G. Greger et al.   MOLECULAR CANCER THERAPEUTICS

S100B protein in neurodegenerative disorders

(2011) Johann Steiner et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Reproducing Crystal Binding Modes of Ligand Functional Groups Using Site-Identification by Ligand Competitive Saturation (SILCS) Simulations

(2011) E. Prabhu Raman et al.   Journal of Chemical Information and Modeling

Evaluation of multiple serum markers in advanced melanoma

(2011) Angel Díaz-Lagares et al.   TUMOR BIOLOGY

Targeting BRAF for patients with melanoma

(2010) H-T Arkenau et al.   BRITISH JOURNAL OF CANCER

Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy

(2010) K H T Paraiso et al.   BRITISH JOURNAL OF CANCER

Mutation-driven drug development in melanoma

(2010) Keith T Flaherty et al.   CURRENT OPINION IN ONCOLOGY

The Calcium-binding Protein S100B Down-regulates p53 and Apoptosis in Malignant Melanoma

(2010) Jing Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

(2010) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Small Molecules Bound to Unique Sites in the Target Protein Binding Cleft of Calcium-Bound S100B As Characterized by Nuclear Magnetic Resonance and X-ray Crystallography

(2009) Thomas H. Charpentier et al.   BIOCHEMISTRY

Applications of Genomics in Melanoma Oncogene Discovery

(2009) Michael F. Berger et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase

(2009) Flora Brozzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Results of a Phase III, Randomized, Placebo-Controlled Study of Sorafenib in Combination With Carboplatin and Paclitaxel As Second-Line Treatment in Patients With Unresectable Stage III or Stage IV Melanoma

(2009) Axel Hauschild et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular dynamics simulation of S100B protein to explore ligand blockage of the interaction with p53 protein

(2009) Zhigang Zhou et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Computational Fragment-Based Binding Site Identification by Ligand Competitive Saturation

(2009) Olgun Guvench et al.   PLoS Computational Biology

S100B's double life: Intracellular regulator and extracellular signal

(2008) Rosario Donato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Refinement of the solution structure and dynamic properties of Ca2+-bound rat S100B

(2008) Nathan T. Wright et al.   JOURNAL OF BIOMOLECULAR NMR

Anti–Cytotoxic T-Lymphocyte Antigen-4 Antibody: The First in an Emerging Class of Immunomodulatory Antibodies for Cancer Treatment

(2008) Lawrence Fong et al.   JOURNAL OF CLINICAL ONCOLOGY

Divalent Metal Ion Complexes of S100B in the Absence and Presence of Pentamidine

(2008) Thomas H. Charpentier et al.   JOURNAL OF MOLECULAR BIOLOGY