Article
Biochemistry & Molecular Biology
Hyun-Ju Han, Chang-Gu Hyun
Summary: The anticoagulant drug acenocoumarol has the potential as a repurposed medication for the treatment of chronic inflammatory diseases. It can decrease the production of inflammatory mediators and cytokines by inhibiting the NF-kappa B and MAPK signaling pathways, leading to attenuated macrophage activation and reduced inflammation.
Article
Plant Sciences
Jirarat Karinchai, Phatcharaporn Budluang, Piya Temviriyanukul, Pisamai Ting, Onanong Nuchuchua, Ariyaphong Wongnoppavich, Arisa Imsumran, Pornsiri Pitchakarn
Summary: This study demonstrated that the hydrophilic fractions of AB exhibit anti-inflammatory activity in LPS-stimulated macrophages. The mechanism used by the AB involves the scavenging of free radicals and the reduction of proinflammatory mediators, including IL-1 beta, IL-6, TNF-alpha, NO, iNOS and COX-2.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Imam Hossen, Zhang Kaiqi, Wu Hua, Xiao Junsong, Huang Mingquan, Cao Yanping
Summary: In this study, the anti-inflammatory effect of epigallocatechin-3-gallate (EGCG) in tea polyphenol extract was investigated using lipopolysaccharide-induced inflammation in RAW 264.7 cells. The results showed that EGCG reduced the production of nitric oxide and reactive oxygen species, suppressed the expression of inflammatory cytokines, and inhibited the signaling pathways associated with inflammation. These findings suggest that EGCG exerts its anti-inflammatory effect by modulating multiple molecular mechanisms.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Jin-Kyu Kang, Hyun-Kyu Kang, Chang-Gu Hyun
Summary: Spiramycin has anti-inflammatory effects by inhibiting the production of pro-inflammatory mediators and cytokines in macrophages, suggesting its potential as a candidate for topical anti-inflammatory agents.
Article
Veterinary Sciences
Takuya Adachi, Eren Ogura, Kumiko Yamamoto, Minoru Ito, Koichi Niwa
Summary: Emu oil was found to alleviate inflammatory mediators production in murine macrophages by inhibiting the NF-κB signaling pathway, suggesting its anti-inflammatory effects.
JAPANESE JOURNAL OF VETERINARY RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Denuja Karunakaran, My-Anh Nguyen, Michele Geoffrion, Dianne Vreeken, Zachary Lister, Henry S. Cheng, Nicola Otte, Patricia Essebier, Hailey Wyatt, Joshua W. Kandiah, Richard Jung, Francis J. Alenghat, Ana Mompeon, Richard Lee, Calvin Pan, Emma Gordon, Adil Rasheed, Aldons J. Lusis, Peter Liu, Ljubica Perisic Matic, Ulf Hedin, Jason E. Fish, Liang Guo, Frank Kolodgie, Renu Virmani, Janine M. van Gils, Katey J. Rayner
Summary: The study indicates that RIPK1 plays a central role in driving inflammation in atherosclerosis by activating the NF-kappa B pathway and promoting the release of inflammatory cytokines. Knockdown of RIPK1 reduces inflammatory cell activation and protects against the progression of atherosclerosis. These findings suggest RIPK1 as a potential therapeutic target to reduce residual inflammation in patients at high risk of coronary artery disease.
Article
Virology
Raymond Tshepiso Makola, Joe Kgaladi, Garland Kgosi More, Petrus Jansen van Vuren, Janusz Tadeusz Paweska, Thabe Moses Matsebatlela
Summary: This study demonstrates that lithium inhibits NF-kB nuclear translocation and modulates inflammation profiles in RVFV-infected Raw 264.7 macrophage cells.
Article
Biochemistry & Molecular Biology
Thomas Linder, Eleni Papaplioura, Diyana Ogurlu, Sophie Geyrhofer, Scarlet Hummelbrunner, Daniel Schachner, Atanas G. Atanasov, Marko D. Mihovilovic, Verena M. Dirsch, Michael Schnuerch
Summary: NF-kappa B inhibitors play a crucial role in inflammation treatment. Through the modification of leoligin, we found that variations in ester functionality and substituents on the tetrahydrofuran scaffold significantly influence the biological activity.
Article
Plant Sciences
Jung A. Lee, Ju Young Shin, Seong Su Hong, Young-Rak Cho, Ju-Hyoung Park, Dong-Wan Seo, Joa Sub Oh, Jae-Shin Kang, Jae Ho Lee, Eun-Kyung Ahn
Summary: Tetracera loureiri is a woody climber found in open deciduous or evergreen forests in Southeast Asia, and its ethanol extract ETL has been shown to inhibit nitric oxide production, reduce expression of pro-inflammatory mediators, and downregulate NF-kappa B and MAPK signaling pathways in LPS-induced macrophages, indicating its potential therapeutic value for inflammatory diseases.
Review
Biochemistry & Molecular Biology
Rebeca Perez, Viviana Burgos, Victor Marin, Antoni Camins, Jordi Olloquequi, Ivan Gonzalez-Chavarria, Henning Ulrich, Ursula Wyneke, Alejandro Luarte, Leandro Ortiz, Cristian Paz
Summary: Neurodegenerative disorders involve the progressive degeneration and death of neurons, and oxidative stress and neuroinflammation play crucial roles in their progression. Two major pathways, Nrf2 and NF-kappa B, have been identified as potential therapeutic targets due to their involvement in oxidative protection and the promotion of cytokine expression, respectively. Caffeic acid phenethyl ester (CAPE), a compound found in propolis, has shown neuroprotective activity by modulating these pathways. This review summarizes the biosynthesis and chemical synthesis of CAPE derivatives and discusses their neuroprotective activity in both in vitro and in vivo studies conducted from 2010 to 2023.
Article
Food Science & Technology
Guohua Zhang, Xianghui Yan, Jiaheng Xia, Zhihong Zhang, Dongsheng Wang, Ping Sheng, Ping Yu, Zheling Zeng
Summary: This study aimed to investigate the anti-inflammatory activity of ethanol extracts (EE) of C. camphora seed and the changes after digestion and hydrolysis. The results showed that EE, digested ethanol extracts (dEE), and hydrolysed ethanol extracts (hEE) exhibited cell protection function and significantly reduced pro-inflammatory mediators and cytokines secretion and expression. Although the anti-inflammatory activity of EE was decreased, most of it was retained after digestion and hydrolysis. The findings suggest that the anti-inflammatory activity of EE is relatively stable and may facilitate the processing and consumption of related products.
Article
Endocrinology & Metabolism
Zitong Wang, Ziyu Gao, Yinghong Zheng, Jiayuan Kou, Dan Song, Xue Yu, Bowen Dong, Tianzuo Chen, Yan Yang, Xi Gao, Qianxue Wang, Ting Ye, Wei Yang, Xu Zhang, Hong Li, Liming Yang
Summary: In this study, it was found that melatonin (Mel) inhibits atherosclerosis (AS) progression by downregulating Galectin-3 (Gal-3) to enhance autophagy and inhibit inflammation. Mel treatment showed promising potential as a treatment for AS.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Plant Sciences
Zhuangwei Zhang, Shuoqi Jiang, Hengqun Tian, Yu Zeng, Kang He, Lin Lin, Fangmiao Yu
Summary: The study aimed to investigate the anti-inflammatory effects of Nymphaea hybrida ethanol extract and its polar fractions. The results showed that the ethyl acetate fraction of NHE exhibited significant inhibitory effects on inflammation by suppressing the activation of NF-kappa B and MAPK pathways in LPS-induced inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Arachchige Maheshika Kumari Jayasinghe, Kirinde Gedara Isuru Sandanuwan Kirindage, Ilekuttige Priyan Shanura Fernando, Kil-Nam Kim, Jae-Young Oh, Ginnae Ahn
Summary: This study demonstrates the protective effect of low molecular weight fucoidan (FSSQ) isolated from Sargassum siliquastrum on lipopolysaccharide (LPS)-stimulated inflammatory responses in RAW 264.7 macrophages. FSSQ increases cell viability while reducing reactive oxygen species production, iNOS and COX-2 expression, as well as NO and prostaglandin E-2 production. FSSQ also downregulates L-1 beta, IL-6, and TNF-alpha expression via modulation of MAPK and NF-kappa B signaling.
Review
Cell Biology
Libin Chen, Xintong Jin, Jian Ma, Bo Xiang, Xiayu Li
Summary: YAP is a transcriptional regulator that plays a role in cell proliferation, organ size, and tissue development and regeneration. Recent research has focused on YAP in inflammation and immunology, revealing its involvement in inflammatory disease and tumor immune escape.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Plant Sciences
Susanne Neugart, Petra Majer, Monika Schreiner, Eva Hideg
Summary: The study found that plants pre-exposed to UV-B showed an increase in flavonoid glycosides after blue light treatment, while green light treatment did not have the same effect. Blue light treatment helped stabilize the concentrations of flavonoid glycosides, and different plant species reacted differently to light quality.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Cell Biology
Christiane Ott, Tobias Jung, Sarah Brix, Cathleen John, Iris R. Betz, Anna Foryst-Ludwig, Stefanie Deubel, Wolfgang M. Kuebler, Tilman Grune, Ulrich Kintscher, Jana Grune
Summary: Cardiac remodeling and contractile dysfunction are major causes of hypertrophy-associated heart failure, characterized by accumulation of modified proteins due to impaired autophagy-lysosomal pathway in aged and diseased hearts. Autophagy inducer rapamycin has cardioprotective effects by improving cardiomyocyte autophagy and contractility. Endothelin 1 (ET-1) decreases autophagy and cardiomyocyte contractility, similar to siAtg5-treated cells and TAC-mice, highlighting the crucial role of autophagy in cardiomyocyte contractility and cardiac performance.
Article
Toxicology
Hansruedi Glatt, Wolfram Engst, Simone Florian, Monika Schreiner, Chimgee Baasanjav-Gerber
Summary: Research has found that consuming Brassica vegetables can lead to the formation of DNA adducts in animal models. These adducts can be attributed to specific phytochemicals. Steaming the vegetables may result in higher levels of adducts in the large intestine due to inactivation of the enzyme responsible for activating the phytochemicals.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Amy Schmiedeskamp, Monika Schreiner, Susanne Baldermann
Summary: This study investigated the potential to increase carotenoid contents in food by choosing food with naturally high carotenoid contents and utilizing thermal processing methods that maintain their stability. Results showed significant variations in carotenoid contents among different colored carrot cultivars, and air frying and deep frying processes led to a significant decrease in total carotenoid contents.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Layla Engelhardt, Tobias Poehnl, Susanne Neugart
Summary: The antioxidant activity of bioactive compounds in fruit and vegetables is influenced by factors such as interaction with other molecules, temperature, and the minerals present. Synergistic effects were observed when a 2:1 ratio of ascorbic acid and 5-caffeoylquinic acid was used in the presence of iron, while an antagonistic effect was seen with a 1:2 ratio. Additionally, the pro-oxidant iron positively influenced the antioxidant activity when combined with the antioxidants, showing complex interactions between these compounds and iron.
Article
Agriculture, Dairy & Animal Science
Martin Schulze, Britta Hensel, David Schroeter, Claus Leiding, Markus Jung, Matthias Lautner
Summary: This case study highlights the contamination of boar bedding material with reprotoxic fungicides leading to a significant decline in boars' production output and sperm quality. Intensive troubleshooting revealed the presence of fenpropimorph in both bedding sawdust and liver samples of affected animals, causing adverse effects on spermatogenesis and spermiogenesis. Autopsy findings also showed testicular hyperemia and degeneration of the germinal epithelium.
REPRODUCTION IN DOMESTIC ANIMALS
(2022)
Article
Plant Sciences
Susanne Neugart, Mark A. Tobler, Paul W. Barnes
Summary: The study with okra plants as a model species showed that plants can react quickly to changes in UV conditions, leading to significant increases in flavonoid content. However, these changes were mainly reflected in UV absorption and antioxidant activity, rather than in soluble flavonoid glycosides and hydroxycinnamic acid derivatives.
Article
Food Science & Technology
Hafiz Rehan Nadeem, Saeed Akhtar, Piero Sestili, Tariq Ismail, Susanne Neugart, Muhammad Qamar, Tuba Esatbeyoglu
Summary: This study investigated the cytotoxicity of basil at different growth stages and found that it was influenced by the stage of growth and concentration of extracts. Ethanol extracts showed the highest content of plant secondary metabolites and antioxidant activity. LC-ESI-MS/MS analysis revealed the presence of known health-promoting and therapeutic compounds in ethanol extracts of basil.
Article
Food Science & Technology
Yudy Barrantes-Martinez, Martha Lievano, Alvaro J. Ruiz, Isabel Cuellar-Rios, Diana Paola Valencia, Melanie Wiesner-Reinhold, Monika Schreiner, Diego Ballesteros-Vivas, Valentina Guzman-Perez
Summary: This study investigated the effect of intervention with a freeze-dried nasturtium drink on insulin response and lipid profile in prediabetic subjects. The results showed that the consumption of nasturtium resulted in a significant decrease in biomarkers related to cardiovascular disease.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Public, Environmental & Occupational Health
Wolfgang Stojetz, Neil T. N. Ferguson, Ghassan Baliki, Oscar Diaz, Jan Elfes, Damir Esenaliev, Hanna Freudenreich, Anke Koebach, Liliana Abreu, Laura Peitz, Ani Todua, Monika Schreiner, Anke Hoeffler, Patricia Justino, Tilman Brueck
Summary: The COVID-19 pandemic is a global crisis that affects everyone. Understanding its impacts and countermeasures requires analyzing individual experiences and behaviors at the micro level from multiple disciplinary perspectives. To facilitate this analysis, the Life with Corona (LwC) survey is introduced as a valuable dataset with desirable properties, allowing for comprehensive understanding of how the pandemic and its countermeasures shape lives and societies over time.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Plant Sciences
Layla Engelhardt, Tobias Poehnl, Susanne Neugart
Summary: Urtica dioica L. and Aegopodium podagraria L., known as stinging nettle and ground elder, are edible wild green vegetables rich in bioactive compounds and antioxidants. The drying methods and cooking can affect the antioxidant activity, and freezer storage has higher antioxidant activity compared to fridge storage. The addition of 5-caffeoylquinic acid can increase the antioxidant activity, especially in freeze-dried samples.
Review
Agriculture, Multidisciplinary
Frederike Sonntag, Huihui Liu, Susanne Neugart
Summary: UV irradiation has been used to reduce decay, delay ripening, and delay senescence in postharvest vegetables. It affects appearance, microbial load, respiration rate, enzymatic antioxidant system, and various bioactive compounds. It has the potential to increase antioxidant activity, delay yellowing and senescence, trigger defense responses, and reduce decay and diseases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Maria Schwarz, Caroline E. Meyer, Alina Loeser, Kristina Lossow, Julian Hackler, Christiane Ott, Susanne Jaeger, Isabelle Mohr, Ella A. Eklund, Angana A. H. Patel, Nadia Gul, Samantha Alvarez, Ilayda Altinonder, Clotilde Wiel, Maria Maares, Hajo Haase, Anetta Haertlova, Tilman Grune, Matthias B. Schulze, Tanja Schwerdtle, Uta Merle, Hans Zischka, Volkan I. Sayin, Lutz Schomburg, Anna P. Kipp
Summary: Selenium homeostasis depends on hepatic biosynthesis of selenoprotein P and its transport from the liver, while copper levels affect the release and transport of selenoprotein P, potentially impacting selenium transport to peripheral organs.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Sophia Walter, Christina Mertens, Martina U. Muckenthaler, Christiane Ott
Summary: Iron is an abundant trace element in the human body and plays essential roles in physiological processes. Aging disrupts iron balance and leads to iron accumulation and inflammation. Inflammation and proteolysis affect iron metabolism, aggravating iron imbalance.
MECHANISMS OF AGEING AND DEVELOPMENT
(2023)
Article
Biochemistry & Molecular Biology
Martin Weiland, Caspar Friedrich Wessler, Thomas Filler, Johannes Glaab, Neysha Lobo Ploch, Ulrike Winterwerber, Melanie Wiesner-Reinhold, Monika Schreiner, Susanne Neugart
Summary: This study investigates the effects of UVB LED lights on lettuce cultivation and found that consistent UVB treatment in indoor farming systems led to a significant increase in desired flavonol glycosides and anthocyanin content compared to inconsistent treatment in greenhouses. The findings suggest that UVB LEDs can be recommended for the development of lighting systems in indoor farming and greenhouse approaches.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2023)