Mother or Father: Who Is in the Front Line? Mechanisms Underlying the Non-Genomic Transmission of Obesity/Diabetes via the Maternal or the Paternal Line

Pregnancy loss of control over eating: a longitudinal study of maternal and child outcomes

(2018) Nadia Micali et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Epigenetics and developmental origins of diabetes: correlation or causation?

(2018) Amita Bansal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Maternal obesity, diabetes during pregnancy and epigenetic mechanisms that influence the developmental origins of cardiometabolic disease in the offspring

(2018) Prasoon Agarwal et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium

(2017) Gemma C Sharp et al.   HUMAN MOLECULAR GENETICS

Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans

(2016) Ida Donkin et al.   Cell Metabolism

Maternal DNA Methylation Regulates Early Trophoblast Development

(2016) Miguel R. Branco et al.   DEVELOPMENTAL CELL

Epigenetic germline inheritance of diet-induced obesity and insulin resistance

(2016) Peter Huypens et al.   NATURE GENETICS

Both diet and gene mutation induced obesity affect oocyte quality in mice

(2016) Yan-Jun Hou et al.   Scientific Reports

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring

(2016) Thais de Castro Barbosa et al.   Molecular Metabolism

When two obese parents are worse than one! Impacts on embryo and fetal development

(2015) N. O. McPherson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

I’m Eating for Two: Parental Dietary Effects on Offspring Metabolism

(2015) Oliver J. Rando et al.   CELL

Multigenerational Undernutrition Increases Susceptibility to Obesity and Diabetes that Is Not Reversed after Dietary Recuperation

(2015) Anandwardhan A. Hardikar et al.   Cell Metabolism

Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors

(2015) L. L. Wu et al.   DEVELOPMENT

Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome

(2015) Jeremy M. Shea et al.   DEVELOPMENTAL CELL

Gestational Diabetes Alters Offspring DNA Methylation Profiles in Human and Rat: Identification of Key Pathways Involved in Endocrine System Disorders, Insulin Signaling, Diabetes Signaling, and ILK Signaling

(2015) Sophie Petropoulos et al.   ENDOCRINOLOGY

Effect of high fat diet on paternal sperm histone distribution and male offspring liver gene expression

(2015) Minoru Terashima et al.   Epigenetics

Effect of male and female body mass index on pregnancy and live birth success after in vitro fertilization

(2015) Karen C. Schliep et al.   FERTILITY AND STERILITY

Body fat mass and the proportion of very large adipocytes in pregnant women are associated with gestational insulin resistance

(2015) H Svensson et al.   INTERNATIONAL JOURNAL OF OBESITY

The early origins of obesity and insulin resistance: timing, programming and mechanisms

(2015) L M Nicholas et al.   INTERNATIONAL JOURNAL OF OBESITY

Altered Circulating miRNA Expression Profile in Pregestational and Gestational Obesity

(2015) Gemma Carreras-Badosa et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Transgenerational effects of obesity and malnourishment on diabetes risk in F2 generation

(2015) Mervat Y. Hanafi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

RNA-mediated epigenetic regulation of gene expression

(2015) Daniel Holoch et al.   NATURE REVIEWS GENETICS

Programming of Obesity and Comorbidities in the Progeny: Lessons from a Model of Diet-Induced Obese Parents

(2015) Fernanda Ornellas et al.   PLoS One

Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress

(2015) Ali B. Rodgers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

(2015) Q. Chen et al.   SCIENCE

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

(2015) U. Sharma et al.   SCIENCE

Intergenerational epigenetic inheritance in models of developmental programming of adult disease

(2015) Denise S. Fernandez-Twinn et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Peri-conception parental obesity, reproductive health, and transgenerational impacts

(2015) Michelle Lane et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Breeding scheme and maternal small RNAs affect the efficiency of transgenerational inheritance of a paramutation in mice

(2015) Shuiqiao Yuan et al.   Scientific Reports

Association between type 2 diabetes and prenatal exposure to the Ukraine famine of 1932–33: a retrospective cohort study

(2015) L H Lumey et al.   Lancet Diabetes & Endocrinology

RNA-mediated paternal heredity of diet-induced obesity and metabolic disorders

(2015) Valérie Grandjean et al.   Scientific Reports

Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity

(2014) Anita Öst et al.   CELL

Maternal diabetes, programming of beta-cell disorders and intergenerational risk of type 2 diabetes

(2014) A. Chavey et al.   DIABETES & METABOLISM

Pre-gestational vs gestational exposure to maternal obesity differentially programs the offspring in mice

(2014) Isaac E. Sasson et al.   DIABETOLOGIA

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

(2014) Katharina Gapp et al.   NATURE NEUROSCIENCE

Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals

(2014) Yanchang Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism

(2014) E. J. Radford et al.   SCIENCE

The “early life” origins of obesity-related health disorders: New discoveries regarding the intergenerational transmission of developmentally programmed traits in the global cardiometabolic health crisis

(2013) Daniel C. Benyshek   AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY

Transgenerational effects of prenatal exposure to the 1944-45 Dutch famine

(2013) MVE Veenendaal et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Influence of Metabolism on Epigenetics and Disease

(2013) William G. Kaelin et al.   CELL

Developmental Programming by Maternal Insulin Resistance: Hyperinsulinemia, Glucose Intolerance, and Dysregulated Lipid Metabolism in Male Offspring of Insulin-Resistant Mice

(2013) E. Isganaitis et al.   DIABETES

Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content

(2013) Tod Fullston et al.   FASEB JOURNAL

Genetics of diabetes – Are we missing the genes or the disease?

(2013) Leif Groop et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Quantification of excess risk for diabetes for those born in times of hunger, in an entire population of a nation, across a century

(2013) S. Thurner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential methylation in glucoregulatory genes of offspring born before vs. after maternal gastrointestinal bypass surgery

(2013) F. Guenard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bridging the transgenerational gap with epigenetic memory

(2013) Jana P. Lim et al.   TRENDS IN GENETICS

High-energy diets may induce a pre-diabetic state altering testicular glycolytic metabolic profile and male reproductive parameters

(2013) L. Rato et al.   Andrology

Body mass index and height over three generations: evidence from the Lifeways cross-generational cohort study

(2012) Celine M Murrin et al.   BMC PUBLIC HEALTH

A novel class of tRNA-derived small RNAs extremely enriched in mature mouse sperm

(2012) Hongying Peng et al.   CELL RESEARCH

A euglycaemic/non-diabetic perinatal environment does not alleviate early beta cell maldevelopment and type 2 diabetes risk in the GK/Par rat model

(2012) A. Chavey et al.   DIABETOLOGIA

Effect of maternal obesity on estrous cyclicity, embryo development and blastocyst gene expression in a mouse model

(2012) P. Bermejo-Alvarez et al.   HUMAN REPRODUCTION

Increased DNA Methylation and Decreased Expression ofPDX-1in Pancreatic Islets from Patients with Type 2 Diabetes

(2012) Beatrice T. Yang et al.   MOLECULAR ENDOCRINOLOGY

High Fat Diet Induced Developmental Defects in the Mouse: Oocyte Meiotic Aneuploidy and Fetal Growth Retardation/Brain Defects

(2012) Kerri M. Luzzo et al.   PLoS One

Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat

(2011) S. E. Pinney et al.   DIABETOLOGIA

Maternal High-Fat Diet Effects on Third-Generation Female Body Size via the Paternal Lineage

(2011) Gregory A. Dunn et al.   ENDOCRINOLOGY

MicroRNAs regulating oxidative stress and inflammation in relation to obesity and atherosclerosis

(2011) Maarten Hulsmans et al.   FASEB JOURNAL

A survey of small RNAs in human sperm

(2011) Stephen A. Krawetz et al.   HUMAN REPRODUCTION

Maternal over-nutrition and offspring obesity predisposition: targets for preventative interventions

(2011) K Rooney et al.   INTERNATIONAL JOURNAL OF OBESITY

The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives

(2011) Lei Chen et al.   Nature Reviews Endocrinology

Dietary Protein Restriction during F0 Pregnancy in Rats Induces Transgenerational Changes in the Hepatic Transcriptome in Female Offspring

(2011) Samuel P. Hoile et al.   PLoS One

SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity

(2011) Nicole O. Palmer et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Current knowledge of obesity's effects in the pre- and periconceptional periods and avenues for future research

(2010) Emily S. Jungheim et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

Exposure to the Chinese Famine in Early Life and the Risk of Hyperglycemia and Type 2 Diabetes in Adulthood

(2010) Y. Li et al.   DIABETES

Global microRNA expression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes

(2010) B. M. Herrera et al.   DIABETOLOGIA

High-Fat Diet Causes Lipotoxicity Responses in Cumulus–Oocyte Complexes and Decreased Fertilization Rates

(2010) Linda Lin-Yan Wu et al.   ENDOCRINOLOGY

Trans–fatty acid levels in sperm are associated with sperm concentration among men from an infertility clinic

(2010) Jorge E. Chavarro et al.   FERTILITY AND STERILITY

Paternal diet-induced obesity impairs embryo development and implantation in the mouse

(2010) Megan Mitchell et al.   FERTILITY AND STERILITY

Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technology

(2010) Hassan W. Bakos et al.   FERTILITY AND STERILITY

Impact of female and male obesity on IVF/ICSI: results of 700,000 ART-cycles in Germany

(2010) Markus S. Kupka et al.   GYNECOLOGICAL ENDOCRINOLOGY

Experimental Intrauterine Growth Restriction Induces Alterations in DNA Methylation and Gene Expression in Pancreatic Islets of Rats

(2010) Reid F. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

(2010) Sheau-Fang Ng et al.   NATURE

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Environmental/lifestyle effects on spermatogenesis

(2010) R. M. Sharpe   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Maternal Diet-Induced Obesity Alters Mitochondrial Activity and Redox Status in Mouse Oocytes and Zygotes

(2010) Natalia Igosheva et al.   PLoS One

Hypertension, Diabetes and Overweight: Looming Legacies of the Biafran Famine

(2010) Martin Hult et al.   PLoS One

Diet-Induced Obesity in Male Mice Is Associated with Reduced Fertility and Potentiation of Acrylamide-Induced Reproductive Toxicity1

(2009) Burhan I. Ghanayem et al.   BIOLOGY OF REPRODUCTION

The miR-124-Sox9 paramutation: RNA-mediated epigenetic control of embryonic and adult growth

(2009) V. Grandjean et al.   DEVELOPMENT

Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes

(2009) Charlotte Ling et al.   DIABETES

From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus

(2009) R. A. DeFronzo   DIABETES

Established diet-induced obesity in female rats leads to offspring hyperphagia, adiposity and insulin resistance

(2009) P. Nivoit et al.   DIABETOLOGIA

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific

(2009) Elmar W. Tobi et al.   HUMAN MOLECULAR GENETICS

Obese Children with Low Birth Weight Demonstrate Impaired β-Cell Function during Oral Glucose Tolerance Test

(2009) Claudia Brufani et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Modulation of Gene Expression by Human Cytosolic tRNase ZL through 5′-Half-tRNA

(2009) Reyad A. Elbarbary et al.   PLoS One

Intergenerational transmission of programmed effects: public health consequences

(2009) Amanda J. Drake et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Epigenetic mechanisms in the development of type 2 diabetes

(2009) Sara E. Pinney et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life

(2008) RC Painter et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

RNA Induction and Inheritance of Epigenetic Cardiac Hypertrophy in the Mouse

(2008) Kay D. Wagner et al.   DEVELOPMENTAL CELL

Intergenerational Transmission of Glucose Intolerance and Obesity by In Utero Undernutrition in Mice

(2008) J. C. Jimenez-Chillaron et al.   DIABETES

Peroxisome Proliferator-Activated Receptor-γ Agonist Rosiglitazone Reverses the Adverse Effects of Diet-Induced Obesity on Oocyte Quality

(2008) Cadence E. Minge et al.   ENDOCRINOLOGY

In vitro fertilization availability and utilization in the United States: a study of demographic, social, and economic factors

(2008) Ahmad O. Hammoud et al.   FERTILITY AND STERILITY

Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1

(2008) Jun H. Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of high-fat diet exposure during fetal life on type 2 diabetes development in the progeny

(2008) Donatella Gniuli et al.   JOURNAL OF LIPID RESEARCH

Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic β cell

(2008) Andreia S. Bernardo et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Persistent epigenetic differences associated with prenatal exposure to famine in humans

(2008) B. T. Heijmans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic programming in the immediate postnatal period

(2008) Malathi Srinivasan et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

One-Cell Zygote Transfer from Diabetic to Nondiabetic Mouse Results in Congenital Malformations and Growth Retardation in Offspring

(2007) Amanda Wyman et al.   ENDOCRINOLOGY

What is an epigenetic transgenerational phenotype?

(2007) Michael K. Skinner   REPRODUCTIVE TOXICOLOGY