When two obese parents are worse than one! Impacts on embryo and fetal development

Identification of early transcriptome signatures in placenta exposed to insulin and obesity

(2015) Luciana Lassance et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Preconception diet or exercise intervention in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring

(2015) Nicole O. McPherson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Reduction of Mitochondrial Function by FCCP During Mouse Cleavage Stage Embryo Culture Reduces Birth Weight and Impairs the Metabolic Health of Offspring1

(2015) Deirdre L. Zander-Fox et al.   BIOLOGY OF REPRODUCTION

Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways

(2015) Thiago Bruder-Nascimento et al.   CLINICAL SCIENCE

Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors

(2015) L. L. Wu et al.   DEVELOPMENT

Association of telomere length and mitochondrial DNA copy number in a community sample of healthy adults

(2015) Audrey R. Tyrka et al.   EXPERIMENTAL GERONTOLOGY

Effect of male and female body mass index on pregnancy and live birth success after in vitro fertilization

(2015) Karen C. Schliep et al.   FERTILITY AND STERILITY

Tissue-specific mtDNA abundance from exome data and its correlation with mitochondrial transcription, mass and respiratory activity

(2015) Anna Maria D'Erchia et al.   MITOCHONDRION

Effects of female increased body mass index on in vitro fertilization cycles outcome

(2015) Hélène Caillon et al.   Obesity Research & Clinical Practice

Programming of Obesity and Comorbidities in the Progeny: Lessons from a Model of Diet-Induced Obese Parents

(2015) Fernanda Ornellas et al.   PLoS One

Hyperglycaemia and lipid differentially impair mouse oocyte developmental competence

(2015) Siew L. Wong et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Peri-conception parental obesity, reproductive health, and transgenerational impacts

(2015) Michelle Lane et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Reduced mtDNA copy number increases the sensitivity of tumor cells to chemotherapeutic drugs

(2015) H Mei et al.   Cell Death & Disease

Genetic Characteristics of Mitochondrial DNA Was Associated with Colorectal Carcinogenesis and Its Prognosis

(2015) Jae-Ho Lee et al.   PLoS One

Newborn regional body composition is influenced by maternal obesity, gestational weight gain and the birthweight standard score

(2014) EM Carlsen et al.   ACTA PAEDIATRICA

Paternal Obesity, Interventions, and Mechanistic Pathways to Impaired Health in Offspring

(2014) Nicole O. McPherson et al.   ANNALS OF NUTRITION AND METABOLISM

Mitochondrial DNA copy number in peripheral blood leukocytes and the risk of clear cell renal cell carcinoma

(2014) S. C. Melkonian et al.   CARCINOGENESIS

Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity

(2014) Anita Öst et al.   CELL

Pre-gestational vs gestational exposure to maternal obesity differentially programs the offspring in mice

(2014) Isaac E. Sasson et al.   DIABETOLOGIA

Stimulation of mitochondrial embryo metabolism by dichloroacetic acid in an aged mouse model improves embryo development and viability

(2014) Nicole O. McPherson et al.   FERTILITY AND STERILITY

Human embryos from overweight and obese women display phenotypic and metabolic abnormalities

(2014) C. Leary et al.   HUMAN REPRODUCTION

Sustained High Protein-tyrosine Phosphatase 1B Activity in the Sperm of Obese Males Impairs the Sperm Acrosome Reaction

(2014) Lei Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of mitochondrial DNA levels with frailty and all-cause mortality

(2014) Foram N. Ashar et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2014) Marie Ng et al.   LANCET

In utero exposure to prepregnancy maternal obesity and postweaning high-fat diet impair regulators of mitochondrial dynamics in rat placenta and offspring

(2014) Sarah J. Borengasser et al.   PHYSIOLOGICAL GENOMICS

The effect of pre-existing maternal obesity and diabetes on placental mitochondrial content and electron transport chain activity

(2014) R. Hastie et al.   PLACENTA

Age-Related Mitochondrial DNA Depletion and the Impact on Pancreatic Beta Cell Function

(2014) Donna L. Nile et al.   PLoS One

Maternal tract factors contribute to paternal seminal fluid impact on metabolic phenotype in offspring

(2014) John J. Bromfield et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fatty acid composition of the follicular fluid of normal weight, overweight and obese women undergoing assisted reproductive treatment: a descriptive cross-sectional study

(2014) Sara DM Valckx et al.   Reproductive Biology and Endocrinology

Proteomic pattern changes associated with obesity-induced asthenozoospermia

(2014) Y. Liu et al.   Andrology

Maternal nutrition and risk of obesity in offspring: The Trojan horse of developmental plasticity

(2013) Sebastian D. Parlee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Maternal Diabetes Causes Alterations of DNA Methylation Statuses of Some Imprinted Genes in Murine Oocytes1

(2013) Zhao-Jia Ge et al.   BIOLOGY OF REPRODUCTION

Male hypogonadism induced by high fat diet and low dose streptozotocin is mediated by activated endoplasmic reticulum stress and IκBβ and attenuated by argirein and valsartan

(2013) Gui-Lai Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content

(2013) Tod Fullston et al.   FASEB JOURNAL

Diet-induced obesity may affect the uterine immune environment in early–mid pregnancy, reducing NK-cell activity and potentially compromising uterine vascularization

(2013) V J Parker et al.   INTERNATIONAL JOURNAL OF OBESITY

Maternal obesity, infertility and mitochondrial dysfunction: potential mechanisms emerging from mouse model systems

(2013) N. M. Grindler et al.   MOLECULAR HUMAN REPRODUCTION

Placental glucose transporter 3 (GLUT3) is up-regulated in human pregnancies complicated by late-onset intrauterine growth restriction

(2013) C. Janzen et al.   PLACENTA

Mouse Zygotes Respond to Severe Sperm DNA Damage by Delaying Paternal DNA Replication and Embryonic Development

(2013) Joanna E. Gawecka et al.   PLoS One

Amount of maternal body fat significantly affected the quality of isolated mouse preimplantation embryos and slowed down their development

(2013) Janka Kubandová et al.   THERIOGENOLOGY

Mitochondrial lipid trafficking

(2013) Takashi Tatsuta et al.   TRENDS IN CELL BIOLOGY

Diet and exercise in an obese mouse fed a high-fat diet improve metabolic health and reverse perturbed sperm function

(2012) Nicole O. Palmer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Does obesity really matter? The impact of BMI on embryo quality and pregnancy outcomes after IVF in women aged ≤38 years

(2012) Deirdre L. Zander-Fox et al.   AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY

Association between obesity and alteration of sperm DNA integrity and mitochondrial activity

(2012) Roberta M. Fariello et al.   BJU INTERNATIONAL

Transmission, inheritance and replication of mitochondrial DNA in mammals: implications for reproductive processes and infertility

(2012) Justin C. St John   CELL AND TISSUE RESEARCH

BMI-related metabolic composition of the follicular fluid of women undergoing assisted reproductive treatment and the consequences for oocyte and embryo quality

(2012) S. D. M. Valckx et al.   HUMAN REPRODUCTION

Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of mice

(2012) T. Fullston et al.   HUMAN REPRODUCTION

The presence of 1 mM glycine in vitrification solutions protects oocyte mitochondrial homeostasis and improves blastocyst development

(2012) Deirdre Zander-Fox et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A

(2012) Richard D. W. Kelly et al.   NUCLEIC ACIDS RESEARCH

High Fat Diet Induced Developmental Defects in the Mouse: Oocyte Meiotic Aneuploidy and Fetal Growth Retardation/Brain Defects

(2012) Kerri M. Luzzo et al.   PLoS One

Paternal Diet-Induced Obesity Retards Early Mouse Embryo Development, Mitochondrial Activity and Pregnancy Health

(2012) Natalie K. Binder et al.   PLoS One

Parental diet-induced obesity leads to retarded early mouse embryo development and altered carbohydrate utilisation by the blastocyst

(2012) Natalie K. Binder et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Insulin Increases Epiblast Cell Number of In Vitro Cultured Mouse Embryos via the PI3K/GSK3/p53 Pathway

(2012) Jared M. Campbell et al.   STEM CELLS AND DEVELOPMENT

Early-Life Origins of Adult Disease: National Longitudinal Population-Based Study of the United States

(2011) Rucker C. Johnson et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Maternal High-Fat Diet Effects on Third-Generation Female Body Size via the Paternal Lineage

(2011) Gregory A. Dunn et al.   ENDOCRINOLOGY

Oocyte morphological abnormalities in overweight women undergoingin vitrofertilization cycles

(2011) Raffaella Depalo et al.   GYNECOLOGICAL ENDOCRINOLOGY

Negative Effect of Increased Body Weight on Sperm Conventional and Nonconventional Flow Cytometric Sperm Parameters

(2011) S. La Vignera et al.   JOURNAL OF ANDROLOGY

Mitochondrial inhibition during preimplantation embryogenesis shifts the transcriptional profile of fetal mouse brain

(2011) Tod Fullston et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity

(2011) Nicole O. Palmer et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Impact of body mass index on seminal oxidative stress

(2010) O. Tunc et al.   ANDROLOGIA

Impaired Mitochondrial Function in the Preimplantation Embryo Perturbs Fetal and Placental Development in the Mouse1

(2010) Sarah L. Wakefield et al.   BIOLOGY OF REPRODUCTION

Diet-Induced Obesity Model: Abnormal Oocytes and Persistent Growth Abnormalities in the Offspring

(2010) Emily S. Jungheim et al.   ENDOCRINOLOGY

High-Fat Diet Causes Lipotoxicity Responses in Cumulus–Oocyte Complexes and Decreased Fertilization Rates

(2010) Linda Lin-Yan Wu et al.   ENDOCRINOLOGY

Paternal diet-induced obesity impairs embryo development and implantation in the mouse

(2010) Megan Mitchell et al.   FERTILITY AND STERILITY

The Epidemiology of Obesity

(2010) Dang M. Nguyen et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Impact of female and male obesity on IVF/ICSI: results of 700,000 ART-cycles in Germany

(2010) Markus S. Kupka et al.   GYNECOLOGICAL ENDOCRINOLOGY

The effect of paternal diet-induced obesity on sperm function and fertilization in a mouse model

(2010) H. W. Bakos et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Regulation of H3K27me3 and H3K4me3 during early porcine embryonic development

(2010) Yu Gao et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

(2010) Sheau-Fang Ng et al.   NATURE

Maternal Diet-Induced Obesity Alters Mitochondrial Activity and Redox Status in Mouse Oocytes and Zygotes

(2010) Natalia Igosheva et al.   PLoS One

Variations in mouse mitochondrial DNA copy number from fertilization to birth are associated with oxidative stress

(2010) Catherine EM Aiken et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Maternal High-Fat Diet Promotes Body Length Increases and Insulin Insensitivity in Second-Generation Mice

(2009) Gregory A. Dunn et al.   ENDOCRINOLOGY

Maternal Overweight and Obesity and the Risk of Congenital Anomalies

(2009) Katherine J. Stothard et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Obese Women Exhibit Differences in Ovarian Metabolites, Hormones, and Gene Expression Compared with Moderate-Weight Women

(2009) Rebecca L. Robker et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Short- and long-term effects of maternal nicotine exposure during lactation on body adiposity, lipid profile, and thyroid function of rat offspring

(2009) E Oliveira et al.   JOURNAL OF ENDOCRINOLOGY

Identification of diabetes- and obesity-associated proteomic changes in human spermatozoa by difference gel electrophoresis

(2009) Thomas M Kriegel et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Disruption of Mitochondrial Malate-Aspartate Shuttle Activity in Mouse Blastocysts Impairs Viability and Fetal Growth1

(2008) Megan Mitchell et al.   BIOLOGY OF REPRODUCTION

Adaptations in placental nutrient transfer capacity to meet fetal growth demands depend on placental size in mice

(2008) P. M. Coan et al.   JOURNAL OF PHYSIOLOGY-LONDON