Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer

Stapled peptide design: principles and roles of computation

(2016) Yaw Sing Tan et al.   DRUG DISCOVERY TODAY

Hepatocyte nuclear factor 1 beta induces transformation and epithelial-to-mesenchymal transition

(2016) Atsuka Matsui et al.   FEBS LETTERS

Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence

(2016) Mareike M. Wiedmann et al.   JOURNAL OF STRUCTURAL BIOLOGY

Peptide stapling techniques based on different macrocyclisation chemistries

(2015) Yu Heng Lau et al.   CHEMICAL SOCIETY REVIEWS

A two-component 'double-click' approach to peptide stapling

(2015) Yu Heng Lau et al.   Nature Protocols

Targeting protein–protein interactions (PPIs) of transcription factors: Challenges of intrinsically disordered proteins (IDPs) and regions (IDRs)

(2015) Susan Sammak et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Macrocycles: lessons from the distant past, recent developments, and future directions

(2015) Andrei K. Yudin   Chemical Science

Variant HNF1 Modulates Epithelial Plasticity of Normal and Transformed Ovary Cells

(2015) Antonella Tomassetti et al.   NEOPLASIA

Linear Aliphatic Dialkynes as Alternative Linkers for Double-Click Stapling of p53-Derived Peptides

(2014) Yu Heng Lau et al.   CHEMBIOCHEM

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

Investigating peptide sequence variations for ‘double-click’ stapled p53 peptides

(2014) Yu Heng Lau et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Functionalised staple linkages for modulating the cellular activity of stapled peptides

(2014) Yu Heng Lau et al.   Chemical Science

New perspectives on molecular targeted therapy in ovarian clear cell carcinoma

(2013) D S P Tan et al.   BRITISH JOURNAL OF CANCER

Targeting Nuclear Import Shuttles, Importins/Karyopherins alpha by a Peptide Mimicking the NFκB1/p50 Nuclear Localization Sequence

(2013) Jozef Zienkiewicz et al.   Journal of the American Heart Association

Comparative Molecular Dynamics Simulation Study of Crystal Environment Effect on Protein Structure

(2012) Tohru Terada et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Molecular basis for specificity of nuclear import and prediction of nuclear localization

(2010) Mary Marfori et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Intrinsically disordered proteins are potential drug targets

(2010) Steven J Metallo   CURRENT OPINION IN CHEMICAL BIOLOGY

Drugs for ‘protein clouds’: targeting intrinsically disordered transcription factors

(2010) A Keith Dunker et al.   CURRENT OPINION IN PHARMACOLOGY

Molecular Basis for the Recognition of Phosphorylated STAT1 by Importin α5

(2010) Jonathan Nardozzi et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes

(2010) K Yamaguchi et al.   ONCOGENE

Regulation of HSulf-1 Expression by Variant Hepatic Nuclear Factor 1 in Ovarian Cancer

(2009) P. Liu et al.   CANCER RESEARCH

Design of Peptide Inhibitors for the Importin α/β Nuclear Import Pathway by Activity-Based Profiling

(2008) Shunichi Kosugi et al.   CHEMISTRY & BIOLOGY

Clear cell carcinoma of the pancreas: histopathologic features and a unique biomarker: hepatocyte nuclear factor-1β

(2008) Lisa Kim et al.   MODERN PATHOLOGY