Article
Multidisciplinary Sciences
John Fadul, Teresa Zulueta-Coarasa, Gloria M. Slattum, Nadja M. Redd, Mauricio Franco Jin, Michael J. Redd, Stephan Daetwyler, Danielle Hedeen, Jan Huisken, Jody Rosenblatt
Summary: The study demonstrates that KRas transformation alone causes cell invasion and partial dedifferentiation independently of mass formation. The invading cells use basal cell extrusion for invasion, and only invading KRas(V12) cells deficient in p53 survive and form internal masses.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yao Fu, Zhuoyue Bi, Lingzhi Li, Priya Wadgaonkar, Yiran Qiu, Bandar Almutairy, Wenxuan Zhang, Akimasa Seno, Chitra Thakur, Fei Chen
Summary: Research has found that environmental arsenic exposure can disrupt the metabolic programs of human bronchial epithelial cells and potentially promote the malignant transformation of cancer cells. Comprehensive metabolomics analysis has provided new insights into the metabolic perturbation caused by arsenic and may contribute to a more precise understanding of arsenic's role in molecular carcinogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Katie L. Bailey, Sara B. Cartwright, Neesha S. Patel, Neeley Remmers, Audrey J. Lazenby, Michael A. Hollingsworth, Mark A. Carlson
Summary: Researchers have developed a large animal model of pancreatic cancer using porcine pancreatic epithelial cells and oncogenic genes, successfully generating a transformed cell line with enhanced activity. Future work will involve implanting these tumorigenic porcine pancreatic cell lines into allogeneic and autologous pigs for preclinical research on diagnostic, interventional, and therapeutic technologies.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Veronica Riccioni, Flavia Trionfetti, Claudia Montaldo, Sabrina Garbo, Francesco Marocco, Cecilia Battistelli, Alessandra Marchetti, Raffaele Strippoli, Laura Amicone, Carla Cicchini, Marco Tripodi
Summary: This study reveals the role of hnRNP-Q in epithelial-mesenchymal transition (EMT) and its regulation of a set of miRNAs, which in turn influences the cellular phenotype and migratory capacity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Sandy Haidar Ahmad, Fatima Al Moussawi, Ranim El Baba, Zeina Nehme, Sebastien Pasquereau, Amit Kumar, Chloe Molimard, Franck Monnien, Marie-Paule Algros, Racha Karaky, Thomas Stamminger, Mona Diab Assaf, Georges Herbein
Summary: Research suggests a close link between HCMV and breast tumor development, with the presence of the UL69 gene in CTH cells and tumor biopsies further highlighting the direct role of HCMV in oncogenesis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lenny K. Hong, Shrinidhi Kadkol, Maria Sverdlov, Irida Kastrati, Mostafa Elhodaky, Ryan Deaton, Karen S. Sfanos, Heidi Wang, Li Liu, Alan M. Diamond
Summary: SELENOF is a selenoprotein involved in prostate cancer, with polymorphisms in the 3'-UTR region affecting the risk of prostate cancer mortality in African American men. Low levels of SELENOF in prostate cancer tissues may contribute to tumor progression and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Tomoko Kamasaki, Yumi Miyazaki, Susumu Ishikawa, Kazuya Hoshiba, Keisuke Kuromiya, Nobuyuki Tanimura, Yusuke Mori, Motosuke Tsutsumi, Tomomi Nemoto, Ryota Uehara, Shiro Suetsugu, Toshiki Itoh, Yasuyuki Fujita
Summary: Research has found that characteristic finger-like membrane protrusions are projected from both normal and RasV12 cells at their interface, and FBP17 protein accumulates in RasV12 cells and surrounding normal cells, playing a positive role in the formation of these protrusions and the apical elimination of RasV12 cells. It is also shown that cdc42 acts upstream of these processes, indicating that the cdc42/FBP17 pathway is a crucial trigger of cell competition.
Review
Oncology
Arthur W. Lambert, Robert A. Weinberg
Summary: Epithelial stem cells play critical roles in tissue generation, maintenance, and repair, while cancer stem cells are implicated in the growth and recurrence of many carcinomas. The activation of epithelial-mesenchymal transition (EMT) is linked to the formation of both normal and neoplastic stem cells, but the mechanistic basis of this connection remains unclear. Understanding the elusive links between EMT programs and the stem cell state will advance our knowledge of normal stem cell biology and cancer pathogenesis.
NATURE REVIEWS CANCER
(2021)
Article
Cell Biology
Keisuke Kuromiya, Kana Aoki, Kojiro Ishibashi, Moe Yotabun, Miho Sekai, Nobuyuki Tanimura, Sayuri Iijima, Susumu Ishikawa, Tomoko Kamasaki, Yuki Akieda, Tohru Ishitani, Takashi Hayashi, Satoshi Toda, Koji Yokoyama, Chol Gyu Lee, Ippei Usami, Haruki Inoue, Ichigaku Takigawa, Estelle Gauquelin, Kaoru Sugimura, Naoya Hino, Yasuyuki Fujita
Summary: In vertebrates, normal cells neighboring transformed cells can enhance cell competition and accelerate the apical extrusion of transformed cells through calcium sparks and phosphorylation of AHNAK2.
Review
Oncology
Jing Yu, Yamin Zhang, Huiyong Zhu
Summary: This study summarizes the current knowledge about the roles and mechanisms of different cell competition interactions between host normal cells and transformed cells involved in mammalian tumor development. These interactions play important roles in different phases of tumor progression, and understanding their molecular mechanisms can provide novel ideas for cancer prevention and treatment.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alessandro Matte, Enrica Federti, Elena Tibaldi, Maria Luisa Di Paolo, Giovanni Bisello, Mariarita Bertoldi, Andrea Carpentieri, Pietro Pucci, Iana Iatcencko, Anand B. Wilson, Veronica Riccardi, Angela Siciliano, Francesco Turrini, Dae Won Kim, Soo Young Choi, Anna Maria Brunati, Lucia De Franceschi
Summary: Prx2, a member of the peroxiredoxin family, is a key cytoplasmic protein in red blood cells that plays a crucial role in detoxifying organic peroxides. Phosphorylation of Prx2 at Tyr-193 by Syk enhances its peroxidase activity and promotes its translocation to the membrane, particularly in red cells exposed to oxidation. The findings highlight a novel connection between redox signaling and Prx2 function in both healthy and diseased red blood cells.
Article
Multidisciplinary Sciences
Selvakumar Anbalagan, Cecilia Stroem, Jessica A. Downs, Penny A. Jeggo, David McBay, Anna Wilkins, Kai Rothkamm, Kevin J. Harrington, John R. Yarnold, Navita Somaiah
Summary: The study suggests that sensitivity to radiotherapy fraction size is dependent on the presence of wild-type p53 and intact non-homologous end-joining. Cells with WT p53 demonstrate split-dose recovery, while NHEJ-deficient cells lack this recovery ability.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Bernard C. H. Lee, Philip S. Robinson, Tim H. H. Coorens, Helen H. N. Yan, Sigurgeir Olafsson, Henry Lee-Six, Mathijs A. Sanders, Hoi Cheong Siu, James Hewinson, Sarah S. K. Yue, Wai Yin Tsui, Annie S. Y. Chan, Anthony K. W. Chan, Siu Lun Ho, Peter J. Campbell, Inigo Martincorena, Simon J. A. Buczacki, Siu Tsan Yuen, Suet Yi Leung, Michael R. Stratton
Summary: The study shows that normal tissues in Lynch Syndrome (LS) patients are genomically stable, while ancestor cells of neoplastic tissues undergo multiple cycles of clonal evolution. This highlights important differences in the pathogenesis of LS from other colorectal cancer predisposition syndromes.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Evelien Eenjes, Marjon Buscop-van Kempen, Anne Boerema-de Munck, Gabriela G. Edel, Floor Benthem, Lisette de Kreij-de Bruin, Marco Schnater, Dick Tibboel, Jennifer Collins, Robbert J. Rottier
Summary: SOX21 patterns the airway epithelium by antagonizing SOX2, regulating differentiation of airway progenitor cells. It inhibits basal to ciliated cell differentiation in both development and adult tracheal epithelium. The interplay between SOX2 and SOX21 is context and concentration dependent, crucial for regulating differentiation of the airway epithelium.
Article
Physics, Multidisciplinary
Sophie Chagnon-Lessard, Hubert Jean-Ruel, Michel Godin, Andrew E. Pelling
Summary: This study investigates the effects of mechanical stretch on epithelial cells, revealing that mechanical strain leads to a more invasive phenotype in transformed cells and alters the metastatic phenotype. The mechanical strain changes the actin cytoskeleton and adhesion complexes of the cells, resulting in a more dynamic invasive system.
FRONTIERS IN PHYSICS
(2021)
Article
Cell Biology
Mercedes Marin-Aguilera, Natalia Jimenez, Oscar Reig, Ruth Montalbo, Ajit K. Verma, Giancarlo Castellano, Lourdes Mengual, Ivan Victoria, Maria V. Pereira, Maria Mila-Guasch, Susana Garcia-Recio, Daniel Benitez-Ribas, Raquel Cabezon, Azucena Gonzalez, Manel Juan, Aleix Prat, Begona Mellado
Article
Gastroenterology & Hepatology
Robert Montal, Daniela Sia, Carla Montironi, Wei Q. Leow, Roger Esteban-Fabro, Roser Pinyol, Miguel Torres-Martin, Laia Bassaganyas, Agrin Moeini, Judit Peix, Laia Cabellos, Miho Maeda, Carlos Villacorta-Martin, Parissa Tabrizian, Leonardo Rodriguez-Carunchio, Giancarlo Castellano, Christine Sempoux, Beatriz Minguez, Timothy M. Pawlik, Ismail Labgaa, Lewis R. Roberts, Manel Sole, Maria Fiel, Swan Thung, Josep Fuster, Sasan Roayaie, Augusto Villanueva, Myron Schwartz, Josep M. Llovet
JOURNAL OF HEPATOLOGY
(2020)
Article
Hematology
Ferran Nadeu, David Martin-Garcia, Guillem Clot, Ander Diaz-Navarro, Marti Duran-Ferrer, Alba Navarro, Roser Vilarrasa-Blasi, Marta Kulis, Romina Royo, Jesus Gutierrez-Abril, Rafael Valdes-Mas, Cristina Lopez, Vicente Chapaprieta, Montserrat Puiggros, Giancarlo Castellano, Dolors Costa, Marta Aymerich, Pedro Jares, Blanca Espinet, Ana Muntanola, Inmaculada Ribera-Cortada, Reiner Siebert, Dolors Colomer, David Torrents, Eva Gine, Armando Lopez-Guillermo, Ralf Kuppers, Jose Martin-Subero, Xose S. Puente, Silvia Bea, Elias Campo
Article
Oncology
Santiago Demajo, Robert Albero, Guillem Clot, Giancarlo Castellano, Alba Navarro, Cristina Capdevila, Anna Enjuanes, Ferran Nadeu, Eva Gine, Magda Pinyol, Elaine S. Jaffe, German Ott, Louis M. Staudt, Andreas Rosenwald, David W. Scott, Lisa M. Rimsza, Armando Lopez-Guillermo, Silvia Bea, Elias Campo, Pedro Jares
Summary: This study identified a cyclin D1-dependent transcriptional program that is overexpressed in MCL and predicts clinical outcome. The gene program mainly involves cell-cycle control and is directly proportional to cyclin D1 levels in MCL tumors. High expression of this program confers an adverse prognosis with shorter overall survival of the patients.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Andrea Rizzo, Alessandro Satta, Giulia Garrone, Adalberto Cavalleri, Alessandra Napoli, Francesco Raspagliesi, Mariangela Figini, Loris De Cecco, Egidio Iorio, Antonella Tomassetti, Delia Mezzanzanica, Marina Bagnoli
Summary: The study showed that down-regulation of CHKA can enhance the sensitivity of OC cells to TRAIL-mediated apoptosis, resulting in increased expression of TRC and TRAIL-R2, regulation of TRAIL-R2 localization, and enhanced TRAIL-induced apoptotic signaling.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Geriatrics & Gerontology
Martina Amanzio, Sara Palermo, Mario Stanziano, Federico D'Agata, Antonello Galati, Salvatore Gentile, Giancarlo Castellano, Massimo Bartoli, Giuseppina Elena Cipriani, Elisa Rubino, Paolo Fonio, Innocenzo Rainero
Summary: Our study reveals a correlation between early frailty in bvFTD patients and a specific pattern of co-occurring GM atrophy and hypometabolism. These findings underscore the potentially critical and precocious role of the insula in the pathogenesis of frailty, combined with executive dysfunction and mood changes, which may lead to a higher risk of poor prognosis.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Meeting Abstract
Oncology
C. Bayo, G. Castellano, T. Ocana, L. Moreira, S. Carballal, A. Sanchez, R. Moreira, O. Ortiz, A. Castells, M. Pellise, M. Juan-Otero, D. Benitez-Ribas, F. Balaguer
ANNALS OF ONCOLOGY
(2021)
Meeting Abstract
Oncology
Laura Ferrer-Mileo, Natalia Jimenez, Oscar Reig, Miguel Angel Climent, Sara Cros, Mariona Figols, Albert Font, Isabel Chirivella, Alejo Rodriguez-Vida, Montserrat Domenech, Enrique Gonzalez-Billalabeitia, Mayra Orrillo, Giancarlo Castellano, Leonardo Rodriguez-Carunchio, Sherley Diaz, Aleix Prat, Mercedes Marin-Aguilera, Begona Mellado
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Antonella Tomassetti
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Alba Gonzalez-Franquesa, Pau Gama-Perez, Marta Kulis, Karolina Szczepanowska, Norma Dahdah, Sonia Moreno-Gomez, Ana Latorre-Pellicer, Rebeca Fernandez-Ruiz, Antoni Aguilar-Mogas, Anne Hoffman, Erika Monelli, Sara Samino, Joan Miro-Blanch, Gregor Oemer, Xavier Duran, Estrella Sanchez-Rebordelo, Marc Schneeberger, Merce Obach, Joel Montane, Giancarlo Castellano, Vicente Chapaprieta, Wenfei Sun, Lourdes Navarro, Ignacio Prieto, Carlos Castano, Anna Novials, Ramon Gomis, Maria Monsalve, Marc Claret, Mariona Graupera, Guadalupe Soria, Christian Wolfrum, Joan Vendrell, Sonia Fernandez-Veledo, Jose Antonio Enriquez, Angel Carracedo, Jose Carlos Perales, Ruben Nogueiras, Laura Herrero, Aleksandra Trifunovic, Markus A. Keller, Oscar Yanes, Marta Sales-Pardo, Roger Guimera, Matthias Blueher, Jose Ignacio Martin-Subero, Pablo M. Garcia-Roves
Summary: This study systematically assessed metabolic plasticity in diet-induced obese mice after a combined nutritional and exercise intervention, and found that there is a significant metabolic dysfunction in visceral white adipose tissue, which leads to a breakdown of metabolic plasticity.
Article
Oncology
Marta Sureda-Gomez, Patricia Balsas, Marta-Leonor Rodriguez, Ferran Nadeu, Anna De Bolos, Alvaro Eguileor, Marta Kulis, Giancarlo Castellano, Cristina Lopez, Eva Gine, Santiago Demajo, Pedro Jares, Jose Martin-Subero, Silvia Bea, Elias Campo, Virginia Amador
Summary: SOX11 overexpression is associated with aggressive behavior in mantle cell lymphomas (MCL). This study finds that SOX11+ MCL cases show enrichment in gene signatures related to leukemic and hematopoietic stem cells, and Musashi-2 (MSI2) is identified as one of the upregulated stem cell-related genes. SOX11 directly binds to the MSI2 promoter and upregulates MSI2 expression. MSI2 upregulation is independently associated with poor overall survival in MCL, and its knockdown leads to decreased expression of genes related to apoptosis and stem cell features, reduced clonogenic growth, tumor cell survival, and chemoresistance in MCL cells.
Meeting Abstract
Oncology
Marta Sureda-Gomez, Patricia Balsas, Marta Leonor Rodriguez, Ferran Nadeu, Anna De Bolos, Alvaro Eguileor, Marta Kulis, Giancarlo Castellano, Jose Ignacio Martin-Subero, Santiago Demajo, Pedro Jares, Eva Gine, Elias Campo, Virginia Amador
Article
Biochemistry & Molecular Biology
Estela Nunez-Manchon, Marti Farrera-Sal, Marc Otero-Mateo, Giancarlo Castellano, Rafael Moreno, David Medel, Ramon Alemany, Eneko Villanueva, Cristina Fillat
Summary: Optimizing codon usage for transgenes can lead to high expression levels initially but impair viral fitness, while using suboptimal codons for transgenes allows stable expression over time without compromising viral replication, resulting in greater oncolytic activity.
Article
Endocrinology & Metabolism
Monica Finessi, Alessandro Bisceglia, Roberto Passera, Ruth Rossetto Giaccherino, Loredana Pagano, Giancarlo Castellano, Ezio Ghigo, Gianni Bisi, Desiree Deandreis
Summary: In patients with hyperthyroidism treated with radioactive iodine, lower baseline TSH values, shorter duration and lower dosage of ATD were associated with better treatment response, while longer ATD duration and higher dosage were associated with worse response.
Meeting Abstract
Hematology
Pablo Mozas, Cristina Lopez, Marta Grau, Sara Valle, Giancarlo Castellano, Alba Navarro, Ferran Nadeu, Blanca Gonzalez-Farre, Alfredo Rivas-Delgado, Andrea Rivero, Juan Gonzalo Correa, Carlos Castillo, Balague Olga, Eva Gine, Julio Delgado, Neus Villamor, Magda Pinyol, Patricia Perez-Galan, Laura Magnano, Elias Campo, Anna Enjuanes, Silvia Bea, Lopez-Guillermo Armando