A two-component 'double-click' approach to peptide stapling

Peptide stapling techniques based on different macrocyclisation chemistries

(2015) Yu Heng Lau et al.   CHEMICAL SOCIETY REVIEWS

Further Insights into the Effects of Pre-organizing the BimBH3 Helix

(2014) Toru Okamoto et al.   ACS Chemical Biology

Comparative α-Helicity of Cyclic Pentapeptides in Water

(2014) Aline D. de Araujo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Linear Aliphatic Dialkynes as Alternative Linkers for Double-Click Stapling of p53-Derived Peptides

(2014) Yu Heng Lau et al.   CHEMBIOCHEM

Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress

(2014) Loren D. Walensky et al.   JOURNAL OF MEDICINAL CHEMISTRY

Investigating peptide sequence variations for ‘double-click’ stapled p53 peptides

(2014) Yu Heng Lau et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Functionalised staple linkages for modulating the cellular activity of stapled peptides

(2014) Yu Heng Lau et al.   Chemical Science

In Vitro Selection of Multiple Libraries Created by Genetic Code Reprogramming To Discover Macrocyclic Peptides That Antagonize VEGFR2 Activity in Living Cells

(2013) Takashi Kawakami et al.   ACS Chemical Biology

Distinct BimBH3 (BimSAHB) Stapled Peptides for Structural and Cellular Studies

(2013) Greg H. Bird et al.   ACS Chemical Biology

A Perfluoroaryl-Cysteine SNAr Chemistry Approach to Unprotected Peptide Stapling

(2013) Alexander M. Spokoyny et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of α-helix-mediated protein–protein interactions using designed molecules

(2013) Valeria Azzarito et al.   Nature Chemistry

Convergent diversity-oriented side-chain macrocyclization scan for unprotected polypeptides

(2013) Yekui Zou et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Stapled Vasoactive Intestinal Peptide (VIP) Derivatives Improve VPAC2 Agonism and Glucose-Dependent Insulin Secretion

(2013) Fabrizio Giordanetto et al.   ACS Medicinal Chemistry Letters

Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity

(2012) Toru Okamoto et al.   ACS Chemical Biology

Macrocyclization of Organo-Peptide Hybrids through a Dual Bio-orthogonal Ligation: Insights from Structure-Reactivity Studies

(2012) John R. Frost et al.   CHEMBIOCHEM

Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors

(2012) Avinash Muppidi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of α-Helical Calpain Probes by Mimicking a Natural Protein–Protein Interaction

(2012) Hyunil Jo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Promoting peptide α-helix formation with dynamic covalent oxime side-chain cross-links

(2011) Conor M. Haney et al.   CHEMICAL COMMUNICATIONS

Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction

(2011) Steven A. Kawamoto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficient Synthesis of Fmoc-Protected Azido Amino Acids

(2011) David Spring et al.   SYNLETT

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

(2010) R. S. Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactivation of p53: from peptides to small molecules

(2010) Christopher J. Brown et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Assessment of helical interfaces in protein–protein interactions

(2009) Andrea L. Jochim et al.   Molecular BioSystems

A Hydrogen Bond Surrogate Approach for Stabilization of Short Peptide Sequences in α-Helical Conformation

(2008) Anupam Patgiri et al.   ACCOUNTS OF CHEMICAL RESEARCH

Development of a Series of Cross-Linking Agents that Effectively Stabilize α-Helical Structures in Various Short Peptides

(2007) Kazuhisa Fujimoto et al.   CHEMISTRY-A EUROPEAN JOURNAL