The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

T cells in Systemic Lupus Erythematosus

(2016) Abel Suárez-Fueyo et al.   CURRENT OPINION IN IMMUNOLOGY

Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer’s Patch T Follicular Helper Cells

(2016) Fei Teng et al.   IMMUNITY

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation

(2016) Hu Zeng et al.   IMMUNITY

Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system

(2016) Sung Hoon Cho et al.   NATURE

Metabolic maintenance of cell asymmetry following division in activated T lymphocytes

(2016) Katherine C. Verbist et al.   NATURE

High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry

(2016) Celi Sun et al.   NATURE GENETICS

Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation

(2016) Kristen N Pollizzi et al.   NATURE IMMUNOLOGY

SWEF Proteins Distinctly Control Maintenance and Differentiation of Hematopoietic Stem Cells

(2016) Tatsiana Ripich et al.   PLoS One

The 4E-BP–eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes

(2016) Lomon So et al.   Science Signaling

The 4E-BP–eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes

(2016) Lomon So et al.   Science Signaling

Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas

(2015) B. Culjkovic-Kraljacic et al.   BLOOD

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells

(2015) John P. Ray et al.   IMMUNITY

Targeting the translation machinery in cancer

(2015) Mamatha Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases

(2015) Andras Perl   Nature Reviews Rheumatology

Kinetic gating mechanism of DNA damage recognition by Rad4/XPC

(2015) Xuejing Chen et al.   Nature Communications

Asymmetric PI3K Signaling Driving Developmental and Regenerative Cell Fate Bifurcation

(2015) Wen-Hsuan W. Lin et al.   Cell Reports

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

(2015) Roybel R Ramiscal et al.   eLife

Mechanistic Target of Rapamycin Complex 1 Expands Th17 and IL-4+ CD4-CD8- Double-Negative T Cells and Contracts Regulatory T Cells in Systemic Lupus Erythematosus

(2014) H. Kato et al.   JOURNAL OF IMMUNOLOGY

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

Translational control of immune responses: from transcripts to translatomes

(2014) Ciriaco A Piccirillo et al.   NATURE IMMUNOLOGY

Growing knowledge of the mTOR signaling network

(2014) Kezhen Huang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dynamic regulation of Bcl6 in follicular helper CD4 T (Tfh) cells

(2013) Youn Soo Choi et al.   CURRENT OPINION IN IMMUNOLOGY

T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming

(2013) Kai Yang et al.   IMMUNITY

Persistent Antigen and Germinal Center B Cells Sustain T Follicular Helper Cell Responses and Phenotype

(2013) Dirk Baumjohann et al.   IMMUNITY

K63 Polyubiquitination and Activation of mTOR by the p62-TRAF6 Complex in Nutrient-Activated Cells

(2013) Juan F. Linares et al.   MOLECULAR CELL

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome

(2013) S. C. Johnson et al.   SCIENCE

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

Interferon-γ Excess Leads to Pathogenic Accumulation of Follicular Helper T Cells and Germinal Centers

(2012) Sau K. Lee et al.   IMMUNITY

Roles of BCL6 in normal and transformed germinal center B cells

(2012) Katia Basso et al.   IMMUNOLOGICAL REVIEWS

DEF6, a Novel Substrate for the Tec Kinase ITK, Contains a Glutamine-rich Aggregation-prone Region and Forms Cytoplasmic Granules that Co-localize with P-bodies

(2012) Fiona Hey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual regulation of IRF4 function in T and B cells is required for the coordination of T–B cell interactions and the prevention of autoimmunity

(2012) Partha S. Biswas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

The translational landscape of mTOR signalling steers cancer initiation and metastasis

(2012) Andrew C. Hsieh et al.   NATURE

Follicular helper T cells in immunity and systemic autoimmunity

(2012) Joseph E. Craft   Nature Reviews Rheumatology

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells

(2011) Wataru Ise et al.   NATURE IMMUNOLOGY

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

(2011) Yeonseok Chung et al.   NATURE MEDICINE

Foxp3+ follicular regulatory T cells control the germinal center response

(2011) Michelle A Linterman et al.   NATURE MEDICINE

Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy

(2010) Weiliang Fan et al.   Autophagy

Roquin Differentiates the Specialized Functions of Duplicated T Cell Costimulatory Receptor Genes Cd28 and Icos

(2009) Michelle A. Linterman et al.   IMMUNITY

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY

SWAP-70-like adapter of T cells: a novel Lck-regulated guanine nucleotide exchange factor coordinating actin cytoskeleton reorganization and Ca2+signaling in T cells

(2009) Stéphane Bécart et al.   IMMUNOLOGICAL REVIEWS

IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis?

(2009) Partha S. Biswas et al.   IMMUNOLOGICAL REVIEWS

Activation of Mammalian Target of Rapamycin Controls the Loss of TCR  in Lupus T Cells through HRES-1/Rab4-Regulated Lysosomal Degradation

(2009) D. R. Fernandez et al.   JOURNAL OF IMMUNOLOGY

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

(2009) Nicolas Fazilleau et al.   NATURE IMMUNOLOGY

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

Bcl6 Mediates the Development of T Follicular Helper Cells

(2009) R. I. Nurieva et al.   SCIENCE