Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING Pathway

Comment on “The Common R71H-G230A-R293Q HumanTMEM173Is a Null Allele”

(2017) Kelsey E. Sivick et al.   JOURNAL OF IMMUNOLOGY

NEMO–IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS–STING Pathway

(2017) Run Fang et al.   JOURNAL OF IMMUNOLOGY

Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways

(2017) Alessandra Zevini et al.   TRENDS IN IMMUNOLOGY

Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion

(2017) Priya Luthra et al.   mBio

A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses

(2017) Kara M. Pryke et al.   mBio

O’nyong-nyong fever: a neglected mosquito-borne viral disease

(2017) Giovanni Rezza et al.   Pathogens and Global Health

NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses

(2016) Haitao Guo et al.   Cell Host & Microbe

Mitochondrial DNA sensing by STING signaling participates in inflammation, cancer and beyond

(2016) Song Liu et al.   INTERNATIONAL JOURNAL OF CANCER

The host STING pathway at the interface of cancer and immunity

(2016) Leticia Corrales et al.   JOURNAL OF CLINICAL INVESTIGATION

Immune-Mediated Protection and Pathogenesis of Chikungunya Virus

(2016) Julie M. Fox et al.   JOURNAL OF IMMUNOLOGY

Both RIG-I and MDA5 detect alphavirus replication in concentration-dependent mode

(2016) Ivan Akhrymuk et al.   VIROLOGY

Alphavirus Infection: Host Cell Shut-Off and Inhibition of Antiviral Responses

(2016) Jelke Fros et al.   Viruses-Basel

Neurological Sequelae Resulting from Encephalitic Alphavirus Infection

(2016) Shannon E. Ronca et al.   Frontiers in Microbiology

Identification and characterization of phosphodiesterases that specifically degrade 3′3′-cyclic GMP-AMP

(2015) Juyi Gao et al.   CELL RESEARCH

Intracellular detection of viral nucleic acids

(2015) Konstantin MJ Sparrer et al.   CURRENT OPINION IN MICROBIOLOGY

Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway

(2015) Sowmya Pattabhi et al.   JOURNAL OF VIROLOGY

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

Mx GTPases: dynamin-like antiviral machines of innate immunity

(2015) Otto Haller et al.   TRENDS IN MICROBIOLOGY

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses

(2015) Tina M. Sali et al.   PLoS Pathogens

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

STING Agonists Induce an Innate Antiviral Immune Response against Hepatitis B Virus

(2014) Fang Guo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING

(2014) Lu Zhang et al.   IMMUNITY

Mouse models of alphavirus-induced inflammatory disease

(2014) A. Taylor et al.   JOURNAL OF GENERAL VIROLOGY

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF- B Activation through TBK1

(2014) T. Abe et al.   JOURNAL OF VIROLOGY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Arrival of Chikungunya Virus in the New World: Prospects for Spread and Impact on Public Health

(2014) Scott C. Weaver   PLoS Neglected Tropical Diseases

Anticancer Flavonoids Are Mouse-Selective STING Agonists

(2013) Sujeong Kim et al.   ACS Chemical Biology

Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling

(2013) Hiroyasu Konno et al.   CELL

Species-specific detection of the antiviral small-molecule compound CMA by STING

(2013) Taner Cavlar et al.   EMBO JOURNAL

The interferon response to intracellular DNA: Why so many receptors?

(2013) Leonie Unterholzner   IMMUNOBIOLOGY

Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid

(2013) J. Conlon et al.   JOURNAL OF IMMUNOLOGY

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

hTERT Extends the Life of Human Fibroblasts without Compromising Type I Interferon Signaling

(2013) Miles C. Smith et al.   PLoS One

Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides

(2013) Guanghui Yi et al.   PLoS One

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

(2013) Tim Wang et al.   SCIENCE

Alphavirus structure: activation for entry at the target cell surface

(2013) Marie-Christine Vaney et al.   Current Opinion in Virology

RIG-I and MDA-5 Detection of Viral RNA-dependent RNA Polymerase Activity Restricts Positive-Strand RNA Virus Replication

(2013) Andrei Nikonov et al.   PLoS Pathogens

Development of a Highly Protective Combination Monoclonal Antibody Therapy against Chikungunya Virus

(2013) Pankaj Pal et al.   PLoS Pathogens

Alphaviruses: Population genetics and determinants of emergence

(2012) Scott C. Weaver et al.   ANTIVIRAL RESEARCH

NF-κB-dependent IL-8 induction by prostaglandin E2receptors EP1and EP4

(2012) F Neuschäfer-Rube et al.   BRITISH JOURNAL OF PHARMACOLOGY

5,6-Dimethylxanthenone-4-acetic Acid (DMXAA) Activates Stimulator of Interferon Gene (STING)-dependent Innate Immune Pathways and Is Regulated by Mitochondrial Membrane Potential

(2012) Daniel Prantner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interferon Response Factors 3 and 7 Protect against Chikungunya Virus Hemorrhagic Fever and Shock

(2012) Penny A. Rudd et al.   JOURNAL OF VIROLOGY

Isoflavone Agonists of IRF-3 Dependent Signaling Have Antiviral Activity against RNA Viruses

(2012) K. M. Bedard et al.   JOURNAL OF VIROLOGY

Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING

(2012) Christian K Holm et al.   NATURE IMMUNOLOGY

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Regulators of innate immunity as novel targets for panviral therapeutics

(2012) Salwa Es-Saad et al.   Current Opinion in Virology

The essential adaptors of innate immune signaling

(2012) Huihui Chen et al.   Protein & Cell

The TLR3/TICAM-1 Pathway Is Mandatory for Innate Immune Responses to Poliovirus Infection

(2011) Hiroyuki Oshiumi et al.   JOURNAL OF IMMUNOLOGY

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

ISG15 Is Critical in the Control of Chikungunya Virus Infection Independent of UbE1L Mediated Conjugation

(2011) Scott W. Werneke et al.   PLoS Pathogens

Pharmacologic Activation of the Innate Immune System to Prevent Respiratory Viral Infections

(2010) Guanjun Cheng et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Type I IFN controls chikungunya virus via its action on nonhematopoietic cells

(2010) Clémentine Schilte et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-β-mediated antiviral activity in vitro and in vivo

(2010) Kari Ann Shirey et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Chikungunya Virus Induces IPS-1-Dependent Innate Immune Activation and Protein Kinase R-Independent Translational Shutoff

(2010) L. K. White et al.   JOURNAL OF VIROLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Understanding the alphaviruses: Recent research on important emerging pathogens and progress towards their control

(2009) E.A. Gould et al.   ANTIVIRAL RESEARCH

Approaching the Asymptote: 20 Years Later

(2009) Ruslan Medzhitov   IMMUNITY

Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IκB Kinase ϵ

(2009) Kristopher Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Cytomegalovirus Induces the Interferon Response via the DNA Sensor ZBP1

(2009) V. R. DeFilippis et al.   JOURNAL OF VIROLOGY

Characteristics of alpha/beta interferon induction after infection of murine fibroblasts with wild-type and mutant alphaviruses

(2009) Crystal W. Burke et al.   VIROLOGY

The IRF Family Transcription Factors in Immunity and Oncogenesis

(2008) Tomohiko Tamura et al.   Annual Review of Immunology

Signalling adaptors used by Toll-like receptors: An update

(2008) Elaine F. Kenny et al.   CYTOKINE

Host responses to alphavirus infection

(2008) Kate D. Ryman et al.   IMMUNOLOGICAL REVIEWS

RNA recognition and signal transduction by RIG-I-like receptors

(2008) Mitsutoshi Yoneyama et al.   IMMUNOLOGICAL REVIEWS

Characterization of the interferon regulatory factor 3-mediated antiviral response in a cell line deficient for IFN production

(2008) Tracy Chew et al.   MOLECULAR IMMUNOLOGY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE