The Arctic AβPP mutation leads to Alzheimer’s disease pathology with highly variable topographic deposition of differentially truncated Aβ

APP mutations in the Aβ coding region are associated with abundant cerebral deposition of Aβ38

(2012) Maria Luisa Moro et al.   ACTA NEUROPATHOLOGICA

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

Aggregation and fibril morphology of the Arctic mutation of Alzheimer’s Aβ peptide by CD, TEM, STEM and in situ AFM

(2012) Nils Norlin et al.   JOURNAL OF STRUCTURAL BIOLOGY

Intraneuronal Aβ accumulation and neurodegeneration: Lessons from transgenic models

(2012) Oliver Wirths et al.   LIFE SCIENCES

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers

(2012) M. Scholl et al.   NEUROLOGY

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

Iowa Variant of Familial Alzheimer’s Disease

(2010) Yasushi Tomidokoro et al.   AMERICAN JOURNAL OF PATHOLOGY

Hereditary Cerebral Hemorrhage With Amyloidosis Associated With the E693K Mutation of APP

(2010) Orso Bugiani et al.   ARCHIVES OF NEUROLOGY

A Mouse Model of Amyloid   Oligomers: Their Contribution to Synaptic Alteration, Abnormal Tau Phosphorylation, Glial Activation, and Neuronal Loss In Vivo

(2010) T. Tomiyama et al.   JOURNAL OF NEUROSCIENCE

Variations in the neuropathology of familial Alzheimer’s disease

(2009) Claire Shepherd et al.   ACTA NEUROPATHOLOGICA

Classification and basic pathology of Alzheimer disease

(2009) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

(2009) Oliver Wirths et al.   ACTA NEUROPATHOLOGICA

Amyloid-β protofibril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice

(2009) Anna Lord et al.   FEBS Journal

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases

(2009) Oliver Wirths et al.   JOURNAL OF NEURAL TRANSMISSION

A new amyloid β variant favoring oligomerization in Alzheimer's-type dementia

(2008) Takami Tomiyama et al.   ANNALS OF NEUROLOGY

Clinical and Neuropathological Features of the Arctic APP Gene Mutation Causing Early-Onset Alzheimer Disease

(2008) Hans Basun et al.   ARCHIVES OF NEUROLOGY

Amyloidogenic Processing of Amyloid Precursor Protein: Evidence of a Pivotal Role of Glutaminyl Cyclase in Generation of Pyroglutamate-Modified Amyloid-β†

(2008) Holger Cynis et al.   BIOCHEMISTRY

PET amyloid ligand [11C]PIB uptake shows predominantly striatal increase in variant Alzheimer's disease

(2008) J. Koivunen et al.   BRAIN