Complexities of Type I Interferon Biology: Lessons from LCMV

Lymphocytic choriomeningitis virus Clone 13 infection causes either persistence or acute death dependent on IFN-1, cytotoxic T lymphocytes (CTLs), and host genetics

(2018) Michael B. A. Oldstone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Difference of two new LCMV strains in lethality and viral genome load in tissues

(2017) Toshikazu Takagi et al.   EXPERIMENTAL ANIMALS

Regulation of CD4 T cells and their effects on immunopathological inflammation following viral infection

(2017) Mitra Bhattacharyya et al.   IMMUNOLOGY

IRF9 Prevents CD8 + T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection

(2017) Magdalena Huber et al.   JOURNAL OF VIROLOGY

Type I Interferon in Chronic Virus Infection and Cancer

(2017) Laura M. Snell et al.   TRENDS IN IMMUNOLOGY

Alpha/beta interferon receptor deficiency in mice significantly enhances susceptibility of the animals to pseudorabies virus infection

(2017) Jingyun Wei et al.   VETERINARY MICROBIOLOGY

Canonical and Non-Canonical Aspects of JAK–STAT Signaling: Lessons from Interferons for Cytokine Responses

(2017) Andrea Majoros et al.   Frontiers in Immunology

The unique role of STAT2 in constitutive and IFN-induced transcription and antiviral responses

(2016) Katarzyna Blaszczyk et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The emerging role of interferon regulatory factor 9 in the antiviral host response and beyond

(2016) Tamara Suprunenko et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects

(2016) Richard Lindqvist et al.   Journal of Neuroinflammation

The Type I Interferon Response Determines Differences in Choroid Plexus Susceptibility between Newborns and Adults in Herpes Simplex Virus Encephalitis

(2016) Douglas R. Wilcox et al.   mBio

Type I Interferon Impairs Specific Antibody Responses Early during Establishment of LCMV Infection

(2016) Matthieu Daugan et al.   Frontiers in Immunology

The interferon-alpha revival in CML

(2015) Moshe Talpaz et al.   ANNALS OF HEMATOLOGY

Blockade of Interferon Beta, but Not Interferon Alpha, Signaling Controls Persistent Viral Infection

(2015) Cherie T. Ng et al.   Cell Host & Microbe

New insights into type I interferon and the immunopathogenesis of persistent viral infections

(2015) Laura M Snell et al.   CURRENT OPINION IN IMMUNOLOGY

Human IFNAR2 deficiency: Lessons for antiviral immunity

(2015) Christopher J. A. Duncan et al.   Science Translational Medicine

Overcoming T cell exhaustion in infection and cancer

(2015) Kristen E. Pauken et al.   TRENDS IN IMMUNOLOGY

Early Virus-Host Interactions Dictate the Course of a Persistent Infection

(2015) Brian M. Sullivan et al.   PLoS Pathogens

RIG-I-like receptors and negative-strand RNA viruses: RLRly bird catches some worms

(2014) Michaela Weber et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Type I Interferon Protects Antiviral CD8+ T Cells from NK Cell Cytotoxicity

(2014) Haifeng C. Xu et al.   IMMUNITY

Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection

(2014) Shivani Srivastava et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MyD88 Plays a Critical T Cell-Intrinsic Role in Supporting CD8 T Cell Expansion during Acute Lymphocytic Choriomeningitis Virus Infection

(2014) A. H. Rahman et al.   JOURNAL OF IMMUNOLOGY

IRF7-Dependent Type I Interferon Production Induces Lethal Immune-Mediated Disease in STAT1 Knockout Mice Infected with Lymphocytic Choriomeningitis Virus

(2014) W. Li et al.   JOURNAL OF VIROLOGY

Correction: Impaired Antibody Response Causes Persistence of Prototypic T Cell–Contained Virus

(2014) Andreas Bergthaler et al.   PLOS BIOLOGY

OASL1 inhibits translation of the type I interferon–regulating transcription factor IRF7

(2013) Myeong Sup Lee et al.   NATURE IMMUNOLOGY

Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection

(2013) E. B. Wilson et al.   SCIENCE

Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling

(2013) J. R. Teijaro et al.   SCIENCE

Interferon regulatory factor 7 (IRF7) is required for the optimal initial control but not subsequent clearance of lymphocytic choriomeningitis virus infection in mice

(2013) Wen Li et al.   VIROLOGY

Negative Regulation of Type I IFN Expression by OASL1 Permits Chronic Viral Infection and CD8+ T-Cell Exhaustion

(2013) Myeong Sup Lee et al.   PLoS Pathogens

Timing and Magnitude of Type I Interferon Responses by Distinct Sensors Impact CD8 T Cell Exhaustion and Chronic Viral Infection

(2012) Yaming Wang et al.   Cell Host & Microbe

Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation

(2012) Jacob Piehler et al.   IMMUNOLOGICAL REVIEWS

Differential Roles for RIG-I-like Receptors and Nucleic Acid-Sensing TLR Pathways in Controlling a Chronic Viral Infection

(2012) J. M. Clingan et al.   JOURNAL OF IMMUNOLOGY

The Depletion of NK Cells Prevents T Cell Exhaustion to Efficiently Control Disseminating Virus Infection

(2012) K. D. Cook et al.   JOURNAL OF IMMUNOLOGY

Mice Deficient in STAT1 but Not STAT2 or IRF9 Develop a Lethal CD4+ T-Cell-Mediated Disease following Infection with Lymphocytic Choriomeningitis Virus

(2012) M. J. Hofer et al.   JOURNAL OF VIROLOGY

Role of Interferon Regulatory Factor 7 in T Cell Responses during Acute Lymphocytic Choriomeningitis Virus Infection

(2012) S. Zhou et al.   JOURNAL OF VIROLOGY

Differential Impact of Interferon Regulatory Factor 7 in Initiation of the Type I Interferon Response in the Lymphocytic Choriomeningitis Virus-Infected Central Nervous System versus the Periphery

(2012) J. E. Christensen et al.   JOURNAL OF VIROLOGY

Signal 3 Cytokines as Modulators of Primary Immune Responses during Infections: The Interplay of Type I IFN and IL-12 in CD8 T Cell Responses

(2012) Selina Jessica Keppler et al.   PLoS One

Plasmacytoid dendritic cells control T-cell response to chronic viral infection

(2012) L. Cervantes-Barragan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tolerability-Adapted Imatinib 800 mg/d Versus 400 mg/d Versus 400 mg/d Plus Interferon-α in Newly Diagnosed Chronic Myeloid Leukemia

(2011) Rüdiger Hehlmann et al.   JOURNAL OF CLINICAL ONCOLOGY

Natural killer cells act as rheostats modulating antiviral T cells

(2011) Stephen N. Waggoner et al.   NATURE

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection

(2011) R. D. Aubert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of the Immunomodulatory and Antiviral Effects of the Cytokine Combination IFN-α and IL-7 in the Lymphocytic Choriomeningitis Virus and Friend Retrovirus Mouse Infection Models

(2011) Annette Audigé et al.   VIRAL IMMUNOLOGY

The role of dendritic cells in viral persistence

(2011) Cherie T Ng et al.   Current Opinion in Virology

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

Induction and Inhibition of Type I Interferon Responses by Distinct Components of Lymphocytic Choriomeningitis Virus

(2010) S. Zhou et al.   JOURNAL OF VIROLOGY

Viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression

(2010) A. Bergthaler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of the Type I Interferon Antiviral Response During Arenavirus Infection

(2010) Persephone Borrow et al.   Viruses-Basel

Hematopoietic cell-derived interferon controls viral replication and virus-induced disease

(2008) P. A. Lang et al.   BLOOD

Lymphocytic choriomeningitis infection of the central nervous system

(2008) Silvia et al.   Frontiers in Bioscience-Landmark

Lymphocytic Choriomeningitis Virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses

(2008) Shenghua Zhou et al.   JOURNAL OF NEUROIMMUNOLOGY