Negative Regulation of Type I IFN Expression by OASL1 Permits Chronic Viral Infection and CD8+ T-Cell Exhaustion

OASL1 inhibits translation of the type I interferon–regulating transcription factor IRF7

(2013) Myeong Sup Lee et al.   NATURE IMMUNOLOGY

Plasmacytoid Dendritic Cells Are Productively Infected and Activated through TLR-7 Early after Arenavirus Infection

(2012) Mónica Macal et al.   Cell Host & Microbe

Timing and Magnitude of Type I Interferon Responses by Distinct Sensors Impact CD8 T Cell Exhaustion and Chronic Viral Infection

(2012) Yaming Wang et al.   Cell Host & Microbe

Plasmacytoid dendritic cells control T-cell response to chronic viral infection

(2012) L. Cervantes-Barragan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleic Acid Recognition by the Innate Immune System

(2011) Roman Barbalat et al.   Annual Review of Immunology

Mechanism of T cell exhaustion in a chronic environment

(2011) Hyun-Tak Jin et al.   BMB Reports

IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

(2011) Marc Pellegrini et al.   CELL

Tight Regulation of Memory CD8+ T Cells Limits Their Effectiveness during Sustained High Viral Load

(2011) Erin E. West et al.   IMMUNITY

Regulation of effector and memory T-cell functions by type I interferon

(2011) Jonathan P. Huber et al.   IMMUNOLOGY

Putting the brakes on the anti-viral response: negative regulators of type I interferon (IFN) production

(2011) Kathryn H. Richards et al.   MICROBES AND INFECTION

A Temporal Role Of Type I Interferon Signaling in CD8+ T Cell Maturation during Acute West Nile Virus Infection

(2011) Amelia K. Pinto et al.   PLoS Pathogens

The Ubiquitin E3 Ligase RAUL Negatively Regulates Type I Interferon through Ubiquitination of the Transcription Factors IRF7 and IRF3

(2010) Yanxing Yu et al.   IMMUNITY

Type I IFN Substitutes for T Cell Help during Viral Infections

(2010) M. Wiesel et al.   JOURNAL OF IMMUNOLOGY

Viral Exploitation of Host SOCS Protein Functions

(2010) L. N. Akhtar et al.   JOURNAL OF VIROLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Pegylated interferons α2a and α2b in the treatment of chronic hepatitis C

(2010) Alessio Aghemo et al.   Nature Reviews Gastroenterology & Hepatology

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

(2010) H.-T. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

Redefining Chronic Viral Infection

(2009) Herbert W. Virgin et al.   CELL

Multiple Mechanisms Contribute to Impairment of Type 1 Interferon Production during Chronic Lymphocytic Choriomeningitis Virus Infection of Mice

(2009) L. N. Lee et al.   JOURNAL OF IMMUNOLOGY

Identification of Amino Acid Residues Critical for the Anti-Interferon Activity of the Nucleoprotein of the Prototypic Arenavirus Lymphocytic Choriomeningitis Virus

(2009) L. Martinez-Sobrido et al.   JOURNAL OF VIROLOGY

IL-21 Is Required to Control Chronic Viral Infection

(2009) H. Elsaesser et al.   SCIENCE

IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection

(2009) A. Frohlich et al.   SCIENCE

Persistent Virus Infection Inhibits Type I Interferon Production by Plasmacytoid Dendritic Cells to Facilitate Opportunistic Infections

(2008) Elina I. Zuniga et al.   Cell Host & Microbe

Innate immunity to virus infection

(2008) Osamu Takeuchi et al.   IMMUNOLOGICAL REVIEWS

Enhancing therapeutic vaccination by blocking PD-1–mediated inhibitory signals during chronic infection

(2008) Sang-Jun Ha et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification and In Vitro Expansion of Functional Antigen-Specific CD25+ FoxP3+ Regulatory T Cells in Hepatitis C Virus Infection

(2008) H. Ebinuma et al.   JOURNAL OF VIROLOGY

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY