Discovery of a Promiscuous Non-Heme Iron Halogenase in Ambiguine Alkaloid Biogenesis: Implication for an Evolvable Enzyme Family for Late-Stage Halogenation of Aliphatic Carbons in Small Molecules
出版年份 2016 全文链接
标题
Discovery of a Promiscuous Non-Heme Iron Halogenase in Ambiguine Alkaloid Biogenesis: Implication for an Evolvable Enzyme Family for Late-Stage Halogenation of Aliphatic Carbons in Small Molecules
作者
关键词
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出版物
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 19, Pages 5780-5784
出版商
Wiley
发表日期
2016-03-31
DOI
10.1002/anie.201601447
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Stereoselective Halogenation in Natural Product Synthesis
- (2016) Won-jin Chung et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Unified biogenesis of ambiguine, fischerindole, hapalindole and welwitindolinone: identification of a monogeranylated indolenine as a cryptic common biosynthetic intermediate by an unusual magnesium-dependent aromatic prenyltransferase
- (2016) Xinyu Liu et al. CHEMICAL COMMUNICATIONS
- Site-Selective Aliphatic C–H Chlorination Using N-Chloroamides Enables a Synthesis of Chlorolissoclimide
- (2016) Ryan K. Quinn et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Halogenase Engineering for the Generation of New Natural Product Analogues
- (2015) Stephanie Brown et al. CHEMBIOCHEM
- More than just a Halogenase: Modification of Fatty Acyl Moieties by a Trifunctional Metal Enzyme
- (2014) Sarah M. Pratter et al. CHEMBIOCHEM
- Identification and Characterization of a Welwitindolinone Alkaloid Biosynthetic Gene Cluster in the Stigonematalean CyanobacteriumHapalosiphon welwitschii
- (2014) Matthew L. Hillwig et al. CHEMBIOCHEM
- Site-Selective Aliphatic C–H Bromination Using N-Bromoamides and Visible Light
- (2014) Valerie A. Schmidt et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A new family of iron-dependent halogenases acts on freestanding substrates
- (2014) Matthew L Hillwig et al. Nature Chemical Biology
- Biosynthesis of Ambiguine Indole Alkaloids in Cyanobacterium Fischerella ambigua
- (2013) Matthew L. Hillwig et al. ACS Chemical Biology
- Biosynthetic Chlorination of the Piperazate Residue in Kutzneride Biosynthesis by KthP
- (2011) Wei Jiang et al. BIOCHEMISTRY
- Manganese Porphyrins Catalyze Selective C−H Bond Halogenations
- (2010) Wei Liu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Substrate-Triggered Formation and Remarkable Stability of the C−H Bond-Cleaving Chloroferryl Intermediate in the Aliphatic Halogenase, SyrB2
- (2009) Megan L. Matthews et al. BIOCHEMISTRY
- Metamorphic enzyme assembly in polyketide diversification
- (2009) Liangcai Gu et al. NATURE
- Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2
- (2009) M. L. Matthews et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Biosynthesis of (−)-(1S,2R)-Allocoronamic Acyl Thioester by an FeII-Dependent Halogenase and a Cyclopropane-Forming Flavoprotein
- (2008) Christopher S. Neumann et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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