Article
Neurosciences
Monica Betta, Giacomo Handjaras, Andrea Leo, Alessandra Federici, Valentina Farinelli, Emiliano Ricciardi, Francesca Siclari, Stefano Meletti, Daniela Ballotta, Francesca Benuzzi, Giulio Bernardi
Summary: EEG slow waves play a crucial role in regulating essential processes such as learning and sensory disconnection. They may involve complex interactions within and between cortical and subcortical structures. Moreover, simultaneous EEG-fMRI recordings show that slow waves are associated with specific hemodynamic changes in different brain regions.
Article
Multidisciplinary Sciences
Stephen Thankachan, Chun Yang, Ksenia Kastanenka, Brian J. Bacskai, Dmitry Gerashchenko
Summary: Non-invasive stimulation technologies have shown potential as treatment options for neurodegenerative disorders. In this study, the researchers developed tools for visual stimulation using light-emitting diodes and compared their effectiveness with traditional optogenetic approaches. The results suggest that visual stimulation can effectively enhance slow wave activity without disrupting sleep patterns.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Simon Ruch, Flavio Jean Schmidig, Leona Knuesel, Katharina Henke
Summary: Slow-wave sleep is a crucial stage for the body's recovery, characterized by slow oscillations in the scalp EEG. Studies have shown that closed-loop sensory stimulation targeting the UP-states of slow oscillations can enhance sleep depth and promote sleep's recuperative functions. However, conventional closed-loop stimulation algorithms may overlook the individual differences in slow oscillations on the scalp. Researchers have proposed a novel EEG-based algorithm, TOPOSO, that can accurately detect and target specific cerebral origins of local slow oscillations.
Article
Clinical Neurology
Brice McConnell, Eugene Kronberg, Peter D. Teale, Stefan H. Sillau, Grace M. Fishback, Rini Kaplan, Angela J. Fought, A. Ranjitha Dhanasekaran, Brian D. Berman, Alberto R. Ramos, Rachel L. McClure, Brianne M. Bettcher
Summary: This study identified different subtypes of spindles within slow wave upstates and found that stages N2 and N3 sleep contain a mixture of discrete subtypes of slow waves. The relative contribution of coupling subtypes shifts across the human lifespan, with a deeper sleep phenotype prevailing with increasing age. These findings support the development of coupling-based biomarkers in age-associated neurological disease.
Article
Neurosciences
Brice V. McConnell, Eugene Kronberg, Lindsey M. Medenblik, Vitaly O. Kheyfets, Alberto R. Ramos, Stefan H. Sillau, Rachelle L. Pulver, Brianne M. Bettcher
Summary: This study aimed to investigate the neurobiological properties and composition of slow wave activity (SWA) during non-rapid-eye-movement (NREM) sleep. The study found that different types of slow waves and spindle subtypes have distinct features and distribution patterns during NREM sleep cycles. Older adults produce a different composition of SWA, with a shift toward the frontal subtype associated with N3 sleep, which becomes increasingly predominant during NREM sleep cycles. These findings are important for understanding the impact of slow wave sleep on memory and neurological diseases.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Stefania Gudrun Eyjolfsdottir, Eugen Trinka, Yvonne Holler
Summary: Both epilepsy and depression are related to abnormalities in slow wave sleep duration and spectral characteristics. Depressive symptoms in epilepsy patients are affected by slow wave sleep duration and clinical factors. Adequate treatment is important for epilepsy patients with depressive symptoms.
EPILEPSY & BEHAVIOR
(2023)
Article
Neurosciences
Bahar Guntekin, Simay Alptekin, Ebru Yildirim, Tuba Akturk, Hakan Uzunlar, Pervin Calisoglu, Figen Eroglu Ada, Enver Atay, Oemer Ceran
Summary: This study aimed to analyze the differences in brain responses between children and young adults during inhibitory processes using event-related design. The results showed that children had increased alpha power in early and late time windows but decreased alpha phase locking in the early time windows compared to young adults. There were also topological differences between the two groups, indicating distinct patterns of alpha phase locking and power in different brain regions.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Kyle K. Morgan, Evan Hathaway, Megan Carson, Mariano Fernandez-Corazza, Roma Shusterman, Phan Luu, Don M. Tucker
Summary: The study found that slow oscillations during deep sleep are not generated by distributed traveling waves in the neocortex, but by relatively focal limbic discharges.
Article
Clinical Neurology
Paola Malerba, Lauren Whitehurst, Sara C. Mednick
Summary: Sleep spindles play an important role in sleep and cognitive functions, especially in the coordination with slow oscillations (SOs) for memory reactivation. This study analyzes the characteristics of spindles and their relation to SOs in different sleep stages and brain regions. Different types of spindles are identified using clustering analysis. The findings suggest a non-uniform participation of spindles in SO-spindle complexes, which has implications for understanding the mechanisms of memory reactivation.
Article
Engineering, Biomedical
Scott Bressler, Ryan Neely, Ryan M. Yost, David Wang, Heather L. Read
Summary: This study examines the feasibility of using a headband wearable device with an endpoint-corrected version of the Hilbert transform algorithm to measure alpha phase and deliver phase-locked auditory stimulation during the transition from wakefulness to sleep. The results show that the wearable system is capable of measuring sleep-related neural activity with high fidelity and delivering auditory stimuli at the intended phases of neural oscillations. This study demonstrates the potential for closed-loop real-time tracking and neuromodulation of sleep-related oscillations using a wearable EEG device.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Clinical Neurology
Evan Hathaway, Kyle Morgan, Megan Carson, Roma Shusterman, Mariano Fernandez-Corazza, Phan Luu, Don M. Tucker
Summary: Research suggests that targeting anterior limbic areas with Transcranial Electrical Stimulation can increase the duration of deep sleep (N3) and improve memory, contributing to overall healthy sleep quality.
Article
Multidisciplinary Sciences
Chen Song, Melanie Boly, Enzo Tagliazucchi, Helmut Laufs, Giulio Tononi
Summary: We identified signatures of sleep in brain hemodynamic activity using simultaneous fMRI and EEG. These signatures can be used to monitor the occurrence of sleep or wakefulness, track the regions that fall asleep or wake up first at the wake-sleep transitions, and investigate local homeostatic sleep processes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
Thaina Rosinvil, Justin Bouvier, Jonathan Dube, Alexandre Lafreniere, Maude Bouchard, Jessica Cyr-Cronier, Nadia Gosselin, Julie Carrier, Jean-Marc Lina
Summary: Aging is associated with reduced density and amplitude of slow waves during nonrapid-eye movement sleep. Adjusting slow wave amplitude criteria based on age and sex reduced differences in wave density and characteristics, with age-related differences being maintained while sex-related differences disappeared. This suggests that age-related decline in slow wave generation is real, rather than an artifact in detection criteria.
Article
Clinical Neurology
Simon J. Schreiner, Esther Werth, Leonie Ballmer, Philipp O. Valko, Kai M. Schubert, Lukas L. Imbach, Christian R. Baumann, Angelina Maric, Heide Baumann-Vogel
Summary: This study found that excessive daytime sleepiness (EDS) in Parkinson disease (PD) is associated with nocturnal sleep disturbance, as indicated by reduced overnight slow-wave activity (SWA) decline and reduced spindle frequency activity.
Article
Engineering, Biomedical
Roisin McMackin, Stefan Dukic, Emmet Costello, Marta Pinto-Grau, Orla Keenan, Antonio Fasano, Teresa Buxo, Mark Heverin, Richard Reilly, Niall Pender, Orla Hardiman, Bahman Nasseroleslami
Summary: The study identified higher anticipation in ALS patients compared to healthy controls during the SART task. Decreased beta-band event-related desynchronization was found in ALS patients, not related to task performance. Patients with higher ALS-specific scores demonstrated stronger beta-band event-related synchronization upon successful withholding.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Manuel Sanchez-Alavez, William Nguyen, Simone Mori, Gianluca Moroncini, Andreu Viader, Daniel K. Nomura, Benjamin F. Cravatt, Bruno Conti
Article
Multidisciplinary Sciences
Daisuke Ogasawara, Hui Deng, Andreu Viader, Marc P. Baggelaar, Arjen Breman, Hans den Dulk, Adriann M. C. H. van den Nieuwendijk, Marjolein Soethoudt, Tom van der Wel, Juan Zhou, Herman S. Overkleeft, Manuel Sanchez-Alavez, Simone Mo, William Nguyen, Bruno Conti, Xiaojie Liu, Yao Chen, Qing-song Liu, Benjamin F. Cravatt, Mario van der Stelt
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Biochemistry & Molecular Biology
Jennifer M. Spaethling, Manuel Sanchez-Alavez, JaeHee Lee, Feng C. Xia, Hannah Dueck, Wenshan Wang, Stephen A. Fisher, Jai-Yoon Sul, Patrick Seale, Junhyong Kim, Tamas Bartfai, James Eberwine
Article
Psychology, Biological
Manuel Sanchez-Alavez, Cindy L. Ehlers
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2016)
Article
Neurosciences
Walter Francesconi, Manuel Sanchez-Alavez, Fulvia Berton, Silvia Alboni, Cristina Benatti, Simone Mori, William Nguyen, Eric Zorrilla, Gianluca Moroncini, Fabio Tascedda, Bruno Conti
JOURNAL OF NEUROSCIENCE
(2016)
Correction
Multidisciplinary Sciences
Daisuke Ogasawara, Hui Deng, Andreu Viader, Marc P. Baggelaar, Arjen Breman, Hans den Dulk, Adrianus M. C. H. van den Nieuwendijk, Marjolein Soethoudt, Tom van der Wel, Juan Zhou, Herman S. Overkleeft, Manuel Sanchez-Alavez, Simone Mori, William Nguyen, Bruno Conti, Xiaojie Liu, Yao Chen, Qing-song Liu, Benjamin F. Cravatt, Mario van der Stelt
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Biology
Andreu Viader, Daisuke Ogasawara, Christopher M. Joslyn, Manuel Sanchez-Alavez, Simone Mori, William Nguyen, Bruno Conti, Benjamin F. Cravatt
Article
Immunology
Simone Mori, Shuei Sugama, William Nguyen, Tatiana Michel, M. Germana Sanna, Manuel Sanchez-Alavez, Rigo Cintron-Colon, Gianluca Moroncini, Yoshihiko Kakinuma, Pamela Maher, Bruno Conti
JOURNAL OF NEUROINFLAMMATION
(2017)
Article
Multidisciplinary Sciences
Rigo Cintron-Colon, Manuel Sanchez-Alavez, William Nguyen, Simone Mori, Ruben Gonzalez-Rivera, Tiffany Lien, Tamas Bartfai, Saba Aid, Jean-Christophe Francois, Martin Holzenberger, Bruno Conti
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Substance Abuse
Manuel Sanchez-Alavez, Derek N. Wills, Leslie Amodeo, Cindy L. Ehlers
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2018)
Article
Substance Abuse
Manuel Sanchez-Alavez, William Nguyen, Simone Mori, Derek N. Wills, Dennis Otero, Carlos A. Aguirre, Mona Singh, Cindy L. Ehlers, Bruno Conti
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2019)
Article
Substance Abuse
Leslie R. Amodeo, Derek N. Wills, Manuel Sanchez-Alavez, Cindy L. Ehlers
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Carlos Guijas, J. Rafael Montenegro-Burke, Rigo Cintron-Colon, Xavier Domingo-Almenara, Manuel Sanchez-Alavez, Carlos A. Aguirre, Kokila Shankar, Erica L-W Majumder, Elizabeth Billings, Bruno Conti, Gary Siuzdak
Article
Clinical Neurology
Cristian O. Mancilla-Corona, Manuel Sanchez-Alavez, Gisela Pineda-Garcia, Julieta Y. Islas-Limon, Oscar E. Zazueta, Jonathan Lopez-Baena, Jesus I. Rodriguez-Vasquez, Idanya R. Serafin-Higuera
Summary: Fatigue has been identified as a persistent condition following COVID-19 infection, affecting cognitive function and performance. This study aimed to investigate the impact of post-COVID fatigue on neuropsychological performance. Participants with post-COVID fatigue and age-matched controls were randomly selected from a database. Both groups completed a health survey and a neuropsychological assessment test via telephone call. Statistical analysis revealed significant regression coefficients between post-COVID fatigue and global parameters of the assessment, indicating a decrease in neuropsychological performance.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)