Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 116, Issue 7, Pages 2545-2550
Publisher
Proceedings of the National Academy of Sciences
Online
2019-01-26
DOI
10.1073/pnas.1811360116
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins
- (2018) Alexander J Martinko et al. eLife
- BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions
- (2018) Nicolas Bery et al. eLife
- Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment
- (2018) Camilo E. Quevedo et al. Nature Communications
- Importance of Rigidity in Designing Small Molecule Drugs To Tackle Protein–Protein Interactions (PPIs) through Stabilization of Desired Conformers
- (2017) Alastair D. G. Lawson et al. JOURNAL OF MEDICINAL CHEMISTRY
- Strategies and challenges for the next generation of antibody–drug conjugates
- (2017) Alain Beck et al. NATURE REVIEWS DRUG DISCOVERY
- A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling
- (2016) Sai Krishna Athuluri-Divakar et al. CELL
- Macrocyclic Prodrugs of a Selective Nonpeptidic Direct Thrombin Inhibitor Display High Permeability, Efficient Bioconversion but Low Bioavailability
- (2016) Vincent Andersson et al. JOURNAL OF MEDICINAL CHEMISTRY
- Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design
- (2016) Jonathan M. L. Ostrem et al. NATURE REVIEWS DRUG DISCOVERY
- Small molecules, big targets: drug discovery faces the protein–protein interaction challenge
- (2016) Duncan E. Scott et al. NATURE REVIEWS DRUG DISCOVERY
- Exploring the surfaceome of Ewing sarcoma identifies a new and unique therapeutic target
- (2016) Jennifer Town et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism
- (2016) P. Lito et al. SCIENCE
- Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State
- (2016) M. P. Patricelli et al. Cancer Discovery
- Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation
- (2015) Jon J. G. Winter et al. JOURNAL OF MEDICINAL CHEMISTRY
- Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations
- (2015) J. C. Hunter et al. MOLECULAR CANCER RESEARCH
- Cancer: The Ras renaissance
- (2015) Heidi Ledford NATURE
- Small-molecule modulation of Ras signaling
- (2014) Jochen Spiegel et al. Nature Chemical Biology
- Drugging the undruggable RAS: Mission Possible?
- (2014) Adrienne D. Cox et al. NATURE REVIEWS DRUG DISCOVERY
- Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange
- (2014) Michael C. Burns et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex
- (2014) H. Sewell et al. Scientific Reports
- K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
- (2013) Jonathan M. Ostrem et al. NATURE
- Regulation of Small GTPases by GEFs, GAPs, and GDIs
- (2013) Jacqueline Cherfils et al. PHYSIOLOGICAL REVIEWS
- Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation
- (2012) Qi Sun et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- A Comprehensive Survey of Ras Mutations in Cancer
- (2012) I. A. Prior et al. CANCER RESEARCH
- Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
- (2012) T. Maurer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Novel Allosteric Sites on Ras for Lead Generation
- (2011) Barry J. Grant et al. PLoS One
- Functional Intracellular Antibody Fragments Do Not Require Invariant Intra-domain Disulfide Bonds
- (2007) Tomoyuki Tanaka et al. JOURNAL OF MOLECULAR BIOLOGY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now