Article
Peripheral Vascular Disease
Eva Munoz Aguilera, Jean Suvan, Marco Orlandi, Queralt Miro Catalina, Jose Nart, Francesco D'Aiuto
Summary: Recent evidence suggests a close relationship between hypertension and periodontitis, with individuals suffering from periodontitis showing higher systolic and diastolic blood pressure compared to those without. The diagnosis of periodontitis is associated with higher systolic blood pressure independently from common cardiovascular risk factors. Promoting periodontal and systemic health strategies may help reduce the burden of hypertension and its complications.
Article
Medicine, General & Internal
O. Yaw Addo, Emma X. Yu, Anne M. Williams, Melissa Fox Young, Andrea J. Sharma, Zuguo Mei, Nicholas J. Kassebaum, Maria Elena D. Jefferds, Parminder S. Suchdev
Summary: Anemia, characterized by low hemoglobin concentration, is a common blood condition worldwide. This study evaluated the WHO's Hb cutoffs for defining anemia among apparently healthy individuals and found that the proposed lower Hb cutoffs are statistically significant but also indicate compensatory increased erythropoiesis. Further research on clinical outcomes is needed to confirm the validity of these proposed Hb cutoffs.
Article
Biochemistry & Molecular Biology
Ana Knezovic, Nikolina Kolobaric, Ines Drenjancevic, Zrinka Mihaljevic, Petar Susnjara, Ivana Jukic, Marko Stupin, Aleksandar Kibel, Saska Marczi, Martina Mihalj, Ana Stupin
Summary: This study aimed to investigate the effect of a 7-day high-salt diet on the initiation of vascular low-grade inflammation in young healthy individuals and the specific role of oxidative stress. The results showed that short-term high-salt diet increased levels of pro-inflammatory and anti-inflammatory cytokines, as well as oxidative stress. It also affected the frequency of Treg cells, suggesting alterations in immune regulatory mechanisms.
Article
Medicine, General & Internal
Jakob Hjorth von Stemann, Ole Birger Vesterager Pedersen, Henrik Hjalgrim, Christian Erikstrup, Henrik Ullum, Joseph Dowsett, Lise Wegner Thorner, Margit Anita Horup Larsen, Erik Sorensen, Morten Bagge Hansen, Sisse Rye Ostrowski
Summary: This study is the first to suggest a potential influence of c-aAb on platelets in healthy individuals, beyond their apparent effects on immune competence.
FRONTIERS IN MEDICINE
(2022)
Article
Microbiology
Stefan Panaiotov, Yordan Hodzhev, Borislava Tsafarova, Vladimir Tolchkov, Reni Kalfin
Summary: This study quantified the culturable part of blood microbiota in healthy individuals using a specific culturing method and medium. The results showed differences in microbial composition between cultured and non-cultured samples, providing insights into the blood microbiota. Further optimization and testing of culturing conditions and media are suggested for better characterization of blood microbiota in both healthy and diseased individuals.
Article
Virology
Elias A. Said, Iman Al-Reesi, Nawal Al-Shizawi, Sanjay Jaju, Mohammed S. Al-Balushi, Crystal Y. Koh, Ali A. Al-Jabri, Lakshmanan Jeyaseelan
Summary: This meta-analysis is the first to report IL-6 levels in the blood of healthy donors based on a large number of studies, with a pooled estimate of 5.186 pg/ml. Results showed that IL-6 values increased by 0.05 pg/ml for every 1 year increase in age. Despite heterogeneity, differences in IL-6 values were within a few pg/ml range, possibly due to varying conditions impacting IL-6 production in the healthy population.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Immunology
Carlos Blanco-Camarillo, Omar Rafael Aleman, Carlos Rosales
Summary: The article discusses the different phenotypes and functional states of neutrophils in healthy and pathological conditions, with a focus on the presence and cellular functions of low-density neutrophils (LDN) in the blood of healthy individuals.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anahit Mkrtchian, Jennifer W. Evans, Christoph Kraus, Peixiong Yuan, Bashkim Kadriu, Allison C. Nugent, Jonathan P. Roiser, Carlos A. Zarate
Summary: Ketamine improved motivational symptoms in patients with treatment-resistant major depressive disorder by normalizing fronto-striatal connectivity, while disrupting this connectivity in healthy volunteers, regardless of inflammatory processes.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Fernando Guerrero-Romero, Francisco X. Castellanos-Juarez, Jose M. Salas-Pacheco, Francisco G. Morales-Gurrola, Alma Cristina Salas-Leal, Luis E. Simental-Mendia
Summary: The study aimed to investigate the association between the expression of TLR4, TLR2, and MyD88 with low-grade chronic inflammation in individuals with metabolically healthy obesity (MHO). The results suggested that overexpression of TLR2, but not TLR4 and MyD88, was associated with low-grade chronic inflammation in subjects with MHO.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Environmental Sciences
Gerd Sallsten, Dag G. Ellingsen, Balazs Berlinger, Stephan Weinbruch, Lars Barregard
Summary: This study aimed to assess the variability of lead in repeated blood and urine samples. The results showed that the within- and between-individual variabilities of urine samples adjusted for creatinine or specific gravity were mostly above 0.5, indicating a high correlation with lead in blood. In addition, there was diurnal variation of urine samples, with lower excretion rate in overnight samples.
ENVIRONMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Baomin Wang, Yumei Yang, Xiaomu Li
Summary: This study investigated the correlations between different blood pressure levels and insulin resistance levels with newly diagnosed diabetes. It found that elevated blood pressure levels and insulin resistance levels were associated with an increased risk of newly diagnosed diabetes. Hypertension was an independent risk factor, and the combination of hypertension with insulin resistance further increased the risk.
JOURNAL OF DIABETES RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Pawel Jarmuzek, Piotr Defort, Marcin Kot, Edyta Wawrzyniak-Gramacka, Barbara Morawin, Agnieszka Zembron-Lacny
Summary: Cytokines play a critical role in tumor cell development and multiplication, but their involvement in glioblastoma (GBM) is still not well understood. This study evaluated the inflammatory profile and identified potential molecular signatures specific to GBM. The results showed elevated neutrophils and neutrophil-to-lymphocyte ratio (NLR) in GBM patients, with an inverse correlation between neutrophil count and survival time. Pro-inflammatory cytokines IL-1 beta, IL-6, and IL-8 were significantly higher in GBM, while TNF alpha and HMGB1 were lower. IL-6 and IL-8 had the highest diagnostic potential for clinical prognosis, with a three-fold higher probability of GBM development above certain threshold values.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Ravi Kant Yadav, Dushyant Kumar Gautam, Chukhu Muj, Madhu Babu Gajula Balija, Indira Paddibhatla
Summary: Studying Drosophila tumor models, we found that the anti-cancer drug Methotrexate has effects on immune responses and tumor formation, such as inhibiting immune responses against wasp infection and reducing tumor penetrance in JAK/STAT pathway mutant.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Laura Emilie Vexo, Sacha Stormlund, Selma Kloeve Landersoe, Henrik Lovendahl Jorgensen, Peter Humaidan, Christina Bergh, Anne Lis Mikkelsen Englund, Anna Klajnbard, Jeanette Wulff Bogstad, Nina la Cour Freiesleben, Anne Zedeler, Lisbeth Praetorius, Anders Nyboe Andersen, Kristine Lossl, Anja Pinborg, Henriette Svarre Nielsen
Summary: Low-grade inflammation, detected by CRP, is associated with the outcome of IVF, including blastocyst quality and pregnancy outcome. Higher baseline CRP concentrations are negatively associated with live birth rate and are associated with pregnancy loss. However, there is no association between CRP concentrations and the number of good-quality blastocysts. More studies are needed to investigate the impact of low-grade inflammation.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Virology
Bo Feng, Bo Liu, Min Cheng, Jie Dong, Yongfeng Hu, Qi Jin, Fan Yang
Summary: Emerging evidence suggests that the gut virome and blood virome play roles in human health and disease, but less is known about the viral communities in blood. In this study, direct metatranscriptomic sequencing of virus-like particles (VLP) in blood from 1200 healthy individuals was conducted to identify different viruses. The study revealed the prevalence of various viruses, including potential transfusion safety-related viruses, and provided important insights for understanding true viral infections in humans.
Letter
Dermatology
Mattias Henning, Kristina Ibler, Isabella Loft, Poul Jennum, Maria Didriksen, Henrik Ullum, Christian Erikstrup, Kaspar Nielsen, Mie Topholm Bruun, Henrik Hjalgrim, Erik Sorensen, Khoa Dinh, Lise Wegner Thorner, Gregor B. Jemec, Ole Pedersen
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Rheumatology
Christian Ammitzboll, Marianne Kragh Thomsen, Jakob Bogh Andersen, Lars Erik Bartels, Marie-Louise From Hermansen, Anders Dahl Johannsen, Clara Elbaek Mistegaard, Susan Mikkelsen, Signe Risbol Vils, Christian Erikstrup, Ellen-Margrethe Hauge, Anne Troldborg
Summary: This study investigated the effect of a two-dose mRNA vaccine on patients with systemic lupus erythematosus or rheumatoid arthritis. The results showed that the vaccine effectively increased patients' antibody levels against SARS-CoV-2 and reduced their fear of COVID-19. However, the use of rituximab, prednisone, and methotrexate had a negative impact on the vaccine response.
MODERN RHEUMATOLOGY
(2023)
Article
Hematology
Camous Moslemi, Susanne Saekmose, Rune Larsen, Thorsten Brodersen, Maria Didriksen, Henrik Hjalgrim, Karina Banasik, Kaspar R. Nielsen, Mie T. Bruun, Joseph Dowsett, Kathrine A. Kasperen, Susan Mikkelsen, Thomas F. Hansen, Henrik Ullum, Christian Erikstrup, Martin L. Olsson, Sisse R. Ostrowski, Ole B. Pedersen
Summary: This study reveals a new association between the Lewis blood group antigen Le(a) and reduced susceptibility to SARS-CoV-2, confirming the previous link to blood type O. However, no associations were found between other blood groups or secretor status and infection, COVID-19 hospitalization, or long COVID-19.
Article
Microbiology
Kamille Fogh, Alexandra R. R. Eriksen, Tine Graakjaer Larsen, Rasmus B. Hasselbalch, Henning Bundgaard, Bibi F. S. S. Scharff, Susanne D. Nielsen, Charlotte S. Jorgensen, Christian Erikstrup, Lars ostergaard, Svend Ellermann-Eriksen, Berit Andersen, Henrik Nielsen, Isik S. Johansen, Lothar Wiese, Lotte Hindhede, Susan Mikkelsen, Susanne G. Saekmose, Bitten Aagaard, Dorte K. Holm, Lene Harritshoj, Lone Simonsen, Thea K. Fischer, Fredrik Folke, Freddy Lippert, Sisse R. Ostrowski, Thomas Benfield, Kare Molbak, Steen Ethelberg, Anders Koch, Anne-Marie Vangsted, Tyra Grove Krause, Anders Fomsgaard, Henrik Ullum, Robert Skov, Kasper Iversen
Summary: This study investigated the immunity against COVID-19, risk factors, and behavior among employees in day care facilities and preschools (DCS) in Denmark. The study found that DCS staff had a higher risk of exposure within their own household than at their workplace. The study also found that most employees expressed fear of contracting COVID-19 and there was limited use of personal protective equipment at work.
MICROBIOLOGY SPECTRUM
(2023)
Article
Environmental Sciences
Bertram Kjerulff, Henriette Thisted Horsdal, Kathrine Kaspersen, Susan Mikkelsen, Khoa Manh Dinh, Margit Horup Larsen, Sisse Rye Ostrowski, Henrik Ullum, Erik Sorensen, Ole Birger Pedersen, Mie Topholm Bruun, Kaspar Rene Nielsen, Jorgen Brandt, Camilla Geels, Lise M. Frohn, Jesper H. Christensen, Torben Sigsgaard, Clive Eric Sabel, Carsten Bocker Pedersen, Christian Erikstrup
Summary: Air pollution is a significant contributor to the global burden of disease, leading to inflammation and various health issues. However, studies on the impact of air pollution exposure on CRP levels in low to moderate pollution settings have yielded inconsistent results.
ENVIRONMENTAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Hildur M. Aegisdottir, Rosa B. Thorolfsdottir, Gardar Sveinbjornsson, Olafur A. Stefansson, Bjarni Gunnarsson, Vinicius Tragante, Gudmar Thorleifsson, Lilja Stefansdottir, Thorgeir E. Thorgeirsson, Egil Ferkingstad, Patrick Sulem, Gudmundur Norddahl, Gudrun Rutsdottir, Karina Banasik, Alex Hoerby Christensen, Christina Mikkelsen, Ole Birger Pedersen, Soren Brunak, Mie Topholm Bruun, Christian Erikstrup, Rikke Louise Jacobsen, Kaspar Rene Nielsen, Erik Sorensen, Michael L. Frigge, Kristjan E. Hjorleifsson, Erna Ivarsdottir, Anna Helgadottir, Solveig Gretarsdottir, Valgerdur Steinthorsdottir, Asmundur Oddsson, Hannes P. Eggertsson, Gisli H. Halldorsson, David A. Jones, Jeffrey L. Anderson, Kirk U. Knowlton, Lincoln D. Nadauld, D. B. D. S. Genomic Consortium DBDS Genomic Consortium, Magnus Haraldsson, Gudmundur Thorgeirsson, Henning Bundgaard, David O. Arnar, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Sisse R. Ostrowsk, Hilma Holm, Kari Stefansson
Summary: This study investigates the genetics of syncope and provides insight into its pathophysiology and prognostic implications. The results show that syncope has a distinct genetic architecture involving neural regulatory processes and a complex relationship with heart rate and blood pressure regulation. There is also a shared genetic background with poor cardiovascular health. Thorough assessment is important for individuals presenting with syncope.
EUROPEAN HEART JOURNAL
(2023)
Article
Clinical Neurology
Mona Ameri Chalmer, Lisette J. A. Kogelman, Ida Callesen, Charlotte Gronvold Christensen, Tanya Ramdal Techlo, Peter L. Moller, Olafur B. Davidsson, Isa A. Olofsson, Michael Schwinn, Susan Mikkelsen, Khoa Manh Dinh, Kaspar Nielsen, Mie Topholm, Christian Erikstrup, Sisse Rye Ostrowski, Ole Birger Pedersen, Henrik Hjalgrim, Karina Banasik, Kristoffer S. Burgdorf, Mette Nyegaard, Jes Olesen, Thomas Folkmann Hansen
Summary: Understanding sex differences in migraine is crucial for improving clinical care. This study provides data on sex differences in migraine presentation from a large European population cohort, showing that females have a higher prevalence and more severe disease burden compared to males.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Genetics & Heredity
Pol Sole-Navais, Christopher Flatley, Valgerdur L. Steinthorsdottir, Marc Vaudel, Julius Juodakis, Jing Chen, Triin Laisk, Abigail C. LaBella, David Westergaard, Jonas Bacelis, Ben Brumpton, Line Skotte, Maria Borges, Oyvind A. Helgeland, Anubha Mahajan, Matthias N. Wielscher, Frederick P. Lin, Catherine Briggs, Carol Wang, Gunn-Helen E. Moen, Robin R. Beaumont, Jonathan Bradfield, Abin A. Abraham, Gudmar Thorleifsson, Maiken Gabrielsen, Sisse Ostrowski, Dominika Modzelewska, Ellen M. Nohr, Elina Hypponen, Amit M. Srivastava, Octavious Talbot, Catherine Allard, Scott Williams, Ramkumar Menon, Beverley Shields, Gardar Sveinbjornsson, Huan B. Xu, Mads F. Melbye, William Lowe, Luigi Bouchard, Emily I. Oken, Ole I. Pedersen, Daniel T. Gudbjartsson, Christian Erikstrup, Erik Sorensen, Rolv Lie, Kari Teramo, Mikko T. Hallman, Thorhildur Juliusdottir, Hakon Hakonarson, Henrik L. Ullum, Andrew Hattersley, Line Sletner, Mario Merialdi, Sheryl Rifas-Shiman, Thora Steingrimsdottir, Denise A. Scholtens, Christine H. Power, Jane West, Mette A. Nyegaard, John Capra, Anne Skogholt, Per Magnus, Ole E. Andreassen, Unnur Thorsteinsdottir, Struan F. A. M. Grant, Elisabeth Qvigstad, Craig I. Pennell, Marie-France A. Hivert, Geoffrey M. Hayes, Marjo-Riitta Jarvelin, Mark I. McCarthy, Deborah Lawlor, Henriette Nielsen, Reedik Maegi, Antonis Rokas, Kristian Hveem, Kari J. Stefansson, Bjarke M. Feenstra, Pal Njolstad, Louis Muglia, Rachel Freathy, Stefan Johanson, Ge Zhang, Bo Jacobsson
Summary: The study conducted a meta-analysis and identified genetic variants associated with gestational duration and preterm delivery. It revealed the importance of maternal alleles in influencing gestational duration and the complex relationship between gestational duration and birth weight. The study also identified antagonistic pleiotropy, where maternal alleles that increase gestational duration have negative effects on birth weight.
Article
Genetics & Heredity
Maria Nethander, Sofia Moverare-Skrtic, Anders Kampe, Eivind Coward, Ene Reimann, Louise Grahnemo, Eva Borbely, Zsuzsanna Helyes, Thomas Funck-Brentano, Martine Cohen-Solal, Juha Tuukkanen, Antti Koskela, Jianyao Wu, Lei Li, Tianyuan Lu, Maiken E. Gabrielsen, Reedik Estonian Biobank Res Team, Reedik Magi, Mari Hoff, Ulf H. Lerner, Petra Henning, Henrik Ullum, Christian Erikstrup, Soren Brunak, Tiinamaija DBDS Genomic Consortium, Arnulf Langhammer, Tiinamaija Tuomi, Asmundur Oddsson, Kari Stefansson, Ulrika Pettersson-Kymmer, Sisse Rye Ostrowski, Ole Birger Vesterager Pedersen, Unnur Styrkarsdottir, Outi Makitie, Kristian Hveem, J. Brent Richards, Claes Ohlsson
Summary: This study identified 43 loci associated with forearm fracture through genome-wide association analysis, including some influencing bone quality parameters. Functional studies of one of these loci revealed that Tac4 knockout mice exhibit reduced mechanical bone strength without affecting bone mineral density.
Article
Genetics & Heredity
Gyda Bjornsdottir, Mona A. Chalmer, Lilja Stefansdottir, Astros Th. Skuladottir, Gudmundur Einarsson, Margret Andresdottir, Doruk Beyter, Egil Ferkingstad, Solveig Gretarsdottir, Bjarni V. Halldorsson, Gisli H. Halldorsson, Anna Helgadottir, Hannes Helgason, Grimur Hjorleifsson Eldjarn, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Ingileif Jonsdottir, Kirk U. Knowlton, Lincoln D. Nadauld, Sigrun H. Lund, Olafur Th. Magnusson, Pall Melsted, Kristjan H. S. Moore, Asmundur Oddsson, Pall I. Olason, Asgeir Sigurdsson, Olafur A. Stefansson, Jona Saemundsdottir, Gardar Sveinbjornsson, Vinicius Tragante, Unnur Unnsteinsdottir, G. Bragi Walters, Florian Zink, Linn Rodevand, Ole A. Andreassen, Jannicke Igland, Rolv T. Lie, Jan Haavik, Karina Banasik, Soren Brunak, Maria Didriksen, Mie T. Bruun, Christian Erikstrup, Lisette J. A. Kogelman, Kaspar R. Nielsen, Erik Sorensen, Ole B. Pedersen, Henrik Ullum, Gisli Masson, Unnur Thorsteinsdottir, Jes Olesen, Petur Ludvigsson, Olafur Thorarensen, Anna Bjornsdottir, Gudrun R. Sigurdardottir, Olafur A. Sveinsson, Sisse R. Ostrowski, Hilma Holm, Daniel F. Gudbjartsson, Gudmar Thorleifsson, Patrick Sulem, Hreinn Stefansson, Thorgeir E. Thorgeirsson, Thomas F. Hansen, Kari Stefansson
Summary: This study combines large GWAS datasets from six European populations to investigate the main subtypes of migraine and identifies new susceptibility loci associated with migraine and its subtypes. Rare variants with large effects on PRRT2, SCN11A, and KCNK5 genes are found to be related to migraine. These findings provide new insights into the complex biology of migraine and its subtypes, offering potential for therapeutic interventions.
Article
Hematology
Louise Ornskov Drechsler, Jens Kjaergaard Boldsen, Lotte Hindhede, Bitten Aagaard, Lene Holm Harritshoj, Christina Mikkelsen, Thorsten Brodersen, Nanna Brons, Michael Schwinn, Henrik Hjalgrim, Klaus Rostgaard, Mie Topholm Bruun, Sisse Rye Ostrowski, Ole Birger Pedersen, Susan Mikkelsen, Christian Erikstrup
Summary: This study examines the effects of ferritin-guided iron supplementation on Danish female first-time blood donors. The intervention resulted in a significant decrease in the risk of low hemoglobin levels and an increase in the number of donations per donor.
Article
Hematology
Camous Moslemi, Susanne G. Saekmose, Rune Larsen, Jakob T. Bay, Thorsten Brodersen, Maria Didriksen, Henrik Hjalgrim, Karina Banasik, Kaspar R. Nielsen, Mie T. Bruun, Joseph Dowsett, Khoa M. Dinh, Susan Mikkelsen, Christina Mikkelsen, Thomas F. Hansen, Henrik Ullum, Christian Erikstrup, Soren Brunak, Karen Angeliki Krogfelt, Jill R. Storry, Sisse R. Ostrowski, Martin L. Olsson, Ole B. Pedersen
Summary: This study demonstrates the viability and accuracy of predicting blood types using existing genotype data. It successfully narrowed down the pool of potential donors with rare blood types and provided a more comprehensive overview of blood types.
Article
Dermatology
P. Lindso Andersen, G. B. Jemec, C. Erikstrup, M. Didriksen, K. M. Dinh, S. Mikkelsen, E. Sorensen, K. R. Nielsen, M. T. Bruun, H. Hjalgrim, T. F. Hansen, S. G. Saekmose, S. R. Ostrowski, D. M. L. Saunte, O. B. Pedersen
Summary: This study investigated the association between HLA alleles and MRSD, identifying five novel associations and confirming one previous association.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)