Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura

FinnGen provides genetic insights from a well-phenotyped isolated population

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Plasma proteomic associations with genetics and health in the UK Biobank

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Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

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Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease

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Burden and attitude to resistant and refractory migraine: a survey from the European Headache Federation with the endorsement of the European Migraine & Headache Alliance

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Genomic Association vs. Serological Determination of ABO Blood Types in a Chinese Cohort, with Application in Mendelian Randomization

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Hemiplegic Migraine Associated With PRRT2 Variations

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Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents

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Migraine Aura: Updates in Pathophysiology and Management

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Interferon-Beta-Induced Headache in Patients with Multiple Sclerosis: Frequency and Characterization

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Pharmacological treatment of migraine: CGRP and 5-HT beyond the triptans

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SCN11A variant as possible pain generator in sensory axonal neuropathy

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Functional study and pathogenicity classification of PRRT2 missense variants in PRRT2 ‐related disorders

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Intranasal lidocaine for acute migraine: A meta-analysis of randomized controlled trials

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Efficient analysis of large-scale genome-wide data with two R packages: bigstatsr and bigsnpr

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PRRT2 controls neuronal excitability by negatively modulating Na+ channel 1.2/1.6 activity

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ARISE: A Phase 3 randomized trial of erenumab for episodic migraine

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Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition

(2018)   CEPHALALGIA

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Poor medical care for people with migraine in Europe – evidence from the Eurolight study

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Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons

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Genome-wide analysis yields new loci associating with aortic valve stenosis

(2018) Anna Helgadottir et al.   Nature Communications

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(2018) Clare Bycroft et al.   NATURE

Graphtyper enables population-scale genotyping using pangenome graphs

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Shared genetic risk between migraine and coronary artery disease: A genome-wide analysis of common variants

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Whole genome characterization of sequence diversity of 15,220 Icelanders

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Weighting sequence variants based on their annotation increases power of whole-genome association studies

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Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation

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Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

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Pharos: Collating protein information to shed light on the druggable genome

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PRRT2 Is a Key Component of the Ca 2+ -Dependent Neurotransmitter Release Machinery

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The evolving spectrum ofPRRT2-associated paroxysmal diseases

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PRRT2 Mutant Leads to Dysfunction of Glutamate Signaling

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LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank

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PRRT2 truncated mutations lead to nonsense-mediated mRNA decay in Paroxysmal Kinesigenic Dyskinesia

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ICHD-3 beta is published. Use it immediately

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A de novo gain-of-function mutation in SCN11A causes loss of pain perception

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A Subset-Based Approach Improves Power and Interpretation for the Combined Analysis of Genetic Association Studies of Heterogeneous Traits

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Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

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Mutations in the Gene PRRT2 Cause Paroxysmal Kinesigenic Dyskinesia with Infantile Convulsions

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Exome sequencing identifies truncating mutations in PRRT2 that cause paroxysmal kinesigenic dyskinesia

(2011) Wan-Jin Chen et al.   NATURE GENETICS

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The Impact of Divergence Time on the Nature of Population Structure: An Example from Iceland

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A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

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Targeting Nerve Growth Factor in Pain

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The International Classification of Headache Disorders

(2008) Jes Olesen   HEADACHE

The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules

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Detection of sharing by descent, long-range phasing and haplotype imputation

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