An atlas of genetic determinants of forearm fracture

Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan

(2022) L. Vandenput et al.   OSTEOPOROSIS INTERNATIONAL

Cytoplasmic polyadenylation by TENT5A is required for proper bone formation

(2021) Olga Gewartowska et al.   Cell Reports

RSPO3 is important for trabecular bone and fracture risk in mice and humans

(2021) Karin H. Nilsson et al.   Nature Communications

LDlinkR: An R Package for Rapidly Calculating Linkage Disequilibrium Statistics in Diverse Populations

(2020) Timothy A. Myers et al.   Frontiers in Genetics

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration

(2020) Joana A. Revez et al.   Nature Communications

Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity

(2020) Hanieh Yaghootkar et al.   DIABETES

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

(2020) Jie Zheng et al.   NATURE GENETICS

Genetic basis of falling risk susceptibility in the UK Biobank Study

(2020) Katerina Trajanoska et al.   Communications Biology

Little evidence for an effect of smoking on multiple sclerosis risk: A Mendelian Randomization study

(2020) Ruth E. Mitchell et al.   PLOS BIOLOGY

Hemokinin-1 is an important mediator of pain in mouse models of neuropathic and inflammatory mechanisms

(2019) Ágnes Hunyady et al.   BRAIN RESEARCH BULLETIN

Treating osteoporosis to prevent fractures: current concepts and future developments

(2019) Mattias Lorentzon   JOURNAL OF INTERNAL MEDICINE

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

(2019) Mengzhen Liu et al.   NATURE GENETICS

Robust methods in Mendelian randomization via penalization of heterogeneous causal estimates

(2019) Jessica M. B. Rees et al.   PLoS One

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

(2018) Carolina Medina-Gomez et al.   AMERICAN JOURNAL OF HUMAN GENETICS

FAM46Amutations are responsible for autosomal recessive osteogenesis imperfecta

(2018) Mathilde Doyard et al.   JOURNAL OF MEDICAL GENETICS

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

(2018) Marie Verbanck et al.   NATURE GENETICS

Causal associations between risk factors and common diseases inferred from GWAS summary data

(2018) Zhihong Zhu et al.   Nature Communications

Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank

(2018) Emmi Tikkanen et al.   Scientific Reports

Mendelian randomization with a binary exposure variable: interpretation and presentation of causal estimates

(2018) Stephen Burgess et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study

(2018) Katerina Trajanoska et al.   BMJ-British Medical Journal

An atlas of genetic influences on osteoporosis in humans and mice

(2018) John A. Morris et al.   NATURE GENETICS

MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data

(2017) Olena O Yavorska et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis

(2017) John P Kemp et al.   NATURE GENETICS

Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis

(2017) Kenneth G. Saag et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional mapping and annotation of genetic associations with FUMA

(2017) Kyoko Watanabe et al.   Nature Communications

Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics

(2016) David Lamparter et al.   PLoS Computational Biology

Multivariable Mendelian Randomization: The Use of Pleiotropic Genetic Variants to Estimate Causal Effects

(2015) S. Burgess et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants: Fig. 1.

(2015) Mitchell J. Machiela et al.   BIOINFORMATICS

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture

(2015) Hou‐Feng Zheng et al.   NATURE

C2H2 zinc finger proteins greatly expand the human regulatory lexicon

(2015) Hamed S Najafabadi et al.   NATURE BIOTECHNOLOGY

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

(2015) Felix R Day et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

A Multivariate Genome-Wide Association Analysis of 10 LDL Subfractions, and Their Response to Statin Treatment, in 1868 Caucasians

(2015) Heejung Shim et al.   PLoS One

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

(2014) John R. B. Perry et al.   NATURE

A general framework for estimating the relative pathogenicity of human genetic variants

(2014) Martin Kircher et al.   NATURE GENETICS

Defining the role of common variation in the genomic and biological architecture of adult human height

(2014) Andrew R Wood et al.   NATURE GENETICS

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures

(2014) Sofia Movérare-Skrtic et al.   NATURE MEDICINE

Laminin α4 Deficient Mice Exhibit Decreased Capacity for Adipose Tissue Expansion and Weight Gain

(2014) Marcella K. Vaicik et al.   PLoS One

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Calculating statistical power in Mendelian randomization studies

(2013) Marie-Jo A Brion et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Hemokinin-1 competitively inhibits substance P-induced stimulation of osteoclast formation and function

(2013) Aya Fukuda et al.   NEUROPEPTIDES

Role of Pituitary Adenylate-Cyclase Activating Polypeptide and Tac1 gene derived tachykinins in sensory, motor and vascular functions under normal and neuropathic conditions

(2013) Bálint Botz et al.   PEPTIDES

A Meta-Analysis of Thyroid-Related Traits Reveals Novel Loci and Gender-Specific Differences in the Regulation of Thyroid Function

(2013) Eleonora Porcu et al.   PLoS Genetics

Heritable and Environmental Factors in the Causation of Clinical Vertebral Fractures

(2012) Helene Wagner et al.   CALCIFIED TISSUE INTERNATIONAL

Annotation of functional variation in personal genomes using RegulomeDB

(2012) A. P. Boyle et al.   GENOME RESEARCH

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

(2012) David W Dempster et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Update on Bone Anabolics in Osteoporosis Treatment: Rationale, Current Status, and Perspectives

(2012) Roland Baron et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

(2012) Karol Estrada et al.   NATURE GENETICS

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

Large-scale association analysis identifies new risk loci for coronary artery disease

(2012) Panos Deloukas et al.   NATURE GENETICS

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk

(2012) Hou-Feng Zheng et al.   PLoS Genetics

A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci

(2011) Jonathan P. Bradfield et al.   PLoS Genetics

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Targeted deletion of the tachykinin 4 gene (TAC4-/-) influences the early stages of B lymphocyte development

(2010) A. Berger et al.   BLOOD

Genetics of Osteoporosis

(2010) Stuart H. Ralston et al.   ENDOCRINE REVIEWS

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

Population genomics in a disease targeted primary cell model

(2009) E. Grundberg et al.   GENOME RESEARCH

N-Cadherin Interacts with Axin and LRP5 To Negatively Regulate Wnt/ -Catenin Signaling, Osteoblast Function, and Bone Formation

(2008) E. Hay et al.   MOLECULAR AND CELLULAR BIOLOGY