Huntingtin associates with the actin cytoskeleton and α-actinin isoforms to influence stimulus dependent morphology changes

The Biology of Huntingtin

(2016) Frédéric Saudou et al.   NEURON

Huntingtin’s spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function

(2016) Ravi Vijayvargia et al.   eLife

Unraveling the Role of Huntingtin in Breast Cancer Metastasis

(2015) Morgane S. Thion et al.   JNCI-Journal of the National Cancer Institute

The actinin family of actin cross-linking proteins – a genetic perspective

(2015) Anita C.H. Murphy et al.   Cell and Bioscience

Unraveling the Role of Huntingtin in Breast Cancer Metastasis

(2015) Morgane S. Thion et al.   JNCI-Journal of the National Cancer Institute

A Large Scale Huntingtin Protein Interaction Network Implicates Rho GTPase Signaling Pathways in Huntington Disease

(2014) Cendrine Tourette et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Huntingtin Is Required for Normal Excitatory Synapse Development in Cortical and Striatal Circuits

(2014) S. U. McKinstry et al.   JOURNAL OF NEUROSCIENCE

Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease

(2014) Nan Wang et al.   NATURE MEDICINE

α-Actinin-2 Mediates Spine Morphology and Assembly of the Post-Synaptic Density in Hippocampal Neurons

(2014) Jennifer L. Hodges et al.   PLoS One

The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signalling

(2013) Cristovão Moreira Sousa et al.   EMBO Molecular Medicine

Competition between α-actinin and Ca2+-Calmodulin Controls Surface Retention of the L-type Ca2+ Channel CaV1.2

(2013) Duane D. Hall et al.   NEURON

Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin

(2013) Nicholas Stephane Caron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic Analysis of Wild-type and Mutant Huntingtin-associated Proteins in Mouse Brains Identifies Unique Interactions and Involvement in Protein Synthesis

(2012) Brady P. Culver et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assembly of non-contractile dorsal stress fibers requires α-actinin-1 and Rac1 in migrating and spreading cells

(2012) Bianca Kovac et al.   JOURNAL OF CELL SCIENCE

Mutant huntingtin impairs immune cell migration in Huntington disease

(2012) Wanda Kwan et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiple phenotypes in Huntington disease mouse neural stem cells

(2012) James J. Ritch et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

(2012) Dyna I. Shirasaki et al.   NEURON

A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease

(2012) John P. Miller et al.   PLoS Genetics

Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease

(2011) Lise Munsie et al.   HUMAN MOLECULAR GENETICS

Dictyostelium huntingtin controls chemotaxis and cytokinesis through the regulation of myosin II phosphorylation

(2011) Yu Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Deficiency of Huntingtin Has Pleiotropic Effects in the Social Amoeba Dictyostelium discoideum

(2011) Michael A. Myre et al.   PLoS Genetics

F-Actin Binding Regions on the Androgen Receptor and Huntingtin Increase Aggregation and Alter Aggregate Characteristics

(2010) Suzanne Angeli et al.   PLoS One

Polyglutamine expansion in huntingtin alters its interaction with phospholipids

(2009) Kimberly B. Kegel et al.   JOURNAL OF NEUROCHEMISTRY

α-Actinin structure and regulation

(2008) B. Sjöblom et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Phosphorylation of Profilin by ROCK1 Regulates Polyglutamine Aggregation

(2008) J. Shao et al.   MOLECULAR AND CELLULAR BIOLOGY