Article
Multidisciplinary Sciences
Vera J. M. Nies, Dicky Struik, Sihao Liu, Weilin Liu, Janine K. Kruit, Michael Downes, Tim van Zutphen, Henkjan J. Verkade, Ronald M. Evans, Johan W. Jonker
Summary: This study found that FGF1 can increase glucose uptake in adipocytes by activating GLUT4 protein. Furthermore, prolonged exposure to FGF1 can stimulate adipocyte glucose uptake by transcription of GLUT1 protein.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Jian-Hong Fang, Jie-Ying Chen, Jia-Lin Zheng, Hui-Xian Zeng, Jun-Guang Chen, Chen-Hui Wu, Jia-Li Cai, Zhi-Yong Wang, Shi-Mei Zhuang
Summary: Angiogenesis plays a crucial role in tumor growth and metastasis, and emerging evidence suggests that metabolic reprogramming in endothelial cells can impact angiogenesis. This study identified multiple regulators in the fructose metabolism pathway that were upregulated in tumor endothelial cells from hepatocellular carcinoma (HCC). It was found that dietary fructose enhanced tumor angiogenesis, growth, and metastasis, which could be attenuated by an inhibitor of fructose transporter SLC2A5. Fructose treatment also promoted endothelial cell proliferation, migration, tube formation, and mitochondrial respiration, while inhibiting fructose metabolism significantly abolished fructose-induced tumor angiogenesis.
Article
Cell Biology
Jie Wang, Zhiwei He, Jian Xu, Peng Chen, Jianxin Jiang
Summary: The study found that LINC00941 acts as an oncogene in the progression of pancreatic cancer, functioning as a ceRNA for miR-335-5p. High expression of LINC00941 was associated with tumor size, lymph node metastasis, and poor prognosis, and its silencing significantly inhibited cell growth and metastasis in PC.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Xigan He, Jinggui Chen, Jiamin Zhou, Anrong Mao, Weiqi Xu, Hongxu Zhu, Qi Pan, Yiming Zhao, Ning Zhang, Longrong Wang, Miao Wang, Zeyang Liu, Weiping Zhu, Lu Wang
Summary: This study identified a newly found lncRNA, EWSAT1, which plays a crucial role in hepatocellular carcinoma (HCC) metastasis. EWSAT1 is significantly upregulated in HCC and is associated with an aggressive phenotype and low patient survival. It promotes proliferation and metastasis of HCC cells by activating the transcription of cancer-related genes through the Hippo-YAP signaling pathway.
Article
Biochemistry & Molecular Biology
Jiazhou Li, Hao Chen, Lang Cai, Daimo Guo, Demao Zhang, Xuedong Zhou, Jing Xie
Summary: This study reveals that SDF-1 alpha promotes chondrocyte autophagy through the CXCR4/mTOR signaling axis, highlighting the importance of autophagy in the survival of chondrocytes in harsh environments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Zhixiong Liu, Minbiao Yan, Wanying Lei, Rencai Jiang, Wenxiu Dai, Jialin Chen, Chaomeng Wang, Li Li, Mei Wu, Ximing Nian, Daopeng Li, Di Sun, Xiaoqi Lv, Chaoying Wang, Changchuan Xie, Luming Yao, Caiming Wu, Jin Hu, Naian Xiao, Wei Mo, Zhanxiang Wang, Liang Zhang
Summary: This study found that the COPII component Sec13 is essential for oligodendrocyte (OL) maturation and myelin repair. Deletion of Sec13 in OLs prevented OPC differentiation and inhibited remyelination after demyelinating injury, while improving protein trafficking or ectopic expression of COPII components accelerated myelination. Loss of Sec13 altered the secretome of OLs and inhibited the secretion of pleiotrophin, which plays a role in promoting OL differentiation and myelin repair.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Oncology
Xin Zhang, Hongwei Zhang, Zhibin Liao, Jiacheng Zhang, Huifang Liang, Weixing Wang, Jia Yu, Keshuai Dong
Summary: This study reveals that SHC4 activates STAT3 signaling to promote hepatocellular carcinoma (HCC) progression. SHC4 overexpression in HCC is associated with poor prognosis, increased migration and invasion. SHC4 enhances cell proliferation, colony formation, migration, and invasion, as well as cell cycle progression and epithelial-mesenchymal transition (EMT) in HCC cells. Additionally, the activation of STAT3 signaling is observed in SHC4 overexpressed HCC cells and tissues. Moreover, intervention of STAT3 confirms its importance in the oncogenic role of SHC4 in HCC.
CANCER CELL INTERNATIONAL
(2022)
Article
Cell Biology
Zucheng Luo, Yujie Bian, Gang Zheng, Huijing Wang, Bingqian Yan, Wenting Su, Wei Dong, Zhichao Hu, Jian Ding, Anyuan Wang, Shi Li, Wei Fu, Jixin Xue
Summary: Random skin flaps are commonly used in plastic and reconstructive surgery for soft tissue defects, but issues with ischemia and necrosis limit their clinical application. Fibroblasts engineered to express modified mRNA encoding SDF-1 alpha have been found to improve vascularization and survival of therapeutic skin flaps. This approach shows promise for enhancing random skin flap regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Zhen-Hua Chen, Qian-Zhi Ni, Xiu-Ping Zhang, Ning Ma, Jing-Kai Feng, Kang Wang, Jing-Jing Li, Dong Xie, Xing-Yuan Ma, Shu-Qun Cheng
Summary: This study revealed that NET1 is upregulated in hepatocellular carcinoma (HCC) and associated with poor prognosis and clinical characteristics. Through promoting Akt phosphorylation and downstream gene expression, NET1 plays an oncogenic role in HCC progression and metastasis.
Article
Cell Biology
Mengyuan Liu, Heming Li, Huijing Zhang, Huan Zhou, Taiwei Jiao, Mingliang Feng, Fangjian Na, Mingjun Sun, Mingfang Zhao, Lei Xue, Lu Xu
Summary: By analyzing high-throughput sequencing datasets, this study identified RBMS1 as a potential promoter gene for gastric cancer metastasis, which activates the JAK2/STAT3 signaling pathway and IL-6 transcriptional activation, promoting cell migration and invasion.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Sanxing Guo, Fengying Li, Yixuan Liang, Yufei Zheng, Yingyi Mo, Deyao Zhao, Zhixiong Jiang, Mengmeng Cui, Lixia Qi, Jiaxing Chen, Lixin Wan, Guoyong Chen, Sidong Wei, Qi Yang, Junqi Liu
Summary: AIFM2 upregulation plays a crucial role in the promotion of HCC metastasis by activating SIRT1/PGC-1α signaling, suggesting it as a potential target for HCC treatment.
Article
Biochemistry & Molecular Biology
Yen-Hao Chen, Hung- Lu, Yu-Ming Wang, Chien-Ming Lo, Shang-Yu Chou, Shau-Hsuan Li
Summary: This study found that SDF-1a plays an important role in the progression of esophageal squamous cell carcinoma (ESCC), and pre-treatment SDF-1a level and kinetics of SDF-1a are independent prognostic factors for ESCC patients receiving definitive chemoradiotherapy (CCRT). Periodic determinations of serum SDF-1a level may be valuable in predicting the prognosis of ESCC in clinical practice.
BIOMEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Shirong Ding, Ying Gao, Dongming Lv, Yalan Tao, Songran Liu, Chen Chen, Zilu Huang, Shuohan Zheng, Yujun Hu, Larry Ka-Yue Chow, Yinghong Wei, Ping Feng, Wei Dai, Xin Wang, Yunfei Xia
Summary: DNTTIP1 is upregulated in nasopharyngeal carcinoma (NPC) and promotes tumor metastasis by regulating the expression of DUSP2 and activating the ERK signaling pathway. Targeting the DNTTIP1/HDAC1-DUSP2 axis with the HDAC inhibitor Chidamide can suppress NPC metastasis.
Article
Neurosciences
Sheng Zhang, Yan Wang, Xiaoqing Zhu, Lanying Song, Xinhua Zhan, Edric Ma, Jennifer McDonough, Hui Fu, Franca Cambi, Judith Grinspan, Fuzheng Guo
Summary: The study reveals that TCF7l2 promotes OL differentiation by repressing BMP4 gene transcription, reducing autocrine BMP4 secretion, and dampening BMP4 signaling. Specific deletion of BMP4 can rescue arrested OL differentiation caused by TCF7l2 disruption in the oligodendroglial lineage.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Oncology
Zongmeng Zhang, Jinlin Du, Qihua Xu, Yuyu Li, Sujin Zhou, Zhenggang Zhao, Yunping Mu, Allan Z. Zhao, Su-Mei Cao, Fanghong Li
Summary: Chronic inflammation is associated with the development of nasopharyngeal carcinoma (NPC), where resistin, an inflammatory cytokine, plays a role in promoting tumor metastasis. High resistin levels in NPC patients are positively correlated with lymph node metastasis, and resistin induces epithelial-mesenchymal transition (EMT) to facilitate metastasis. The TLR4/p38 MAPK/NF-kappa B signaling pathways are involved in resistin-mediated promotion of NPC metastasis.
Article
Oncology
Jorge Gomez-Miragaya, Ander Diaz-Navarro, Raul Tonda, Sergi Beltran, Luis Palomero, Marta Palafox, Lacey E. Dobrolecki, Chen Huang, Suhas Vasaikar, Bing Zhang, Gerburg M. Wulf, Alejandro Collado-Sole, Eva M. Trinidad, Purificacion Munoz, Laia Pare, Aleix Prat, Alejandra Bruna, Carlos Caldas, Joaquin Arribas, Maria Teresa Soler-Monso, Anna Petit, Judith Balmana, Cristina Cruz, Violeta Serra, Miguel Angel Pujana, Michael T. Lewis, Xose S. Puente, Eva Gonzalez-Suarez
Review
Oncology
Roger von Moos, Luis Costa, Eva Gonzalez-Suarez, Evangelos Terpos, Daniela Niepel, Jean-Jacques Body
CANCER TREATMENT REVIEWS
(2019)
Article
Biochemistry & Molecular Biology
Laia Pique, Alexia Martinez de Paz, David Pineyro, Anna Martinez-Cardus, Manuel Castro de Moura, Pere Llinas-Arias, Fernando Setien, Jorge Gomez-Miragaya, Eva Gonzalez-Suarez, Stefan Sigurdsson, Jon G. Jonasson, Alberto Villanueva, August Vidal, Veronica Davalos, Manel Esteller
Article
Cell Biology
Adriana Iriarte, Agnes Figueras, Pau Cerda, Jose Maria Mora, Anna Jucgla, Rosa Penin, Francesc Vinals, Antoni Riera-Mestre
Article
Biochemistry & Molecular Biology
Ferran Medina-Jover, Nuria Gendrau-Sanclemente, Francesc Vinals
Article
Oncology
Adria Bernat-Peguera, Juan Navarro-Ventura, Laura Lorenzo-Sanz, Victoria da Silva-Diz, Mattia Bosio, Luis Palomero, Rosa M. Penin, Diana Perez Sidelnikova, Josep Oriol Bermejo, Miren Taberna, Noelia Vilarino, Josep M. Piulats, Ricard Mesia, Joan Maria Vinals, Eva Gonzalez-Suarez, Salvador Capella-Gutierrez, Alberto Villanueva, Francesc Vinals, Purificacion Munoz
Summary: EGFR-targeted therapy may be effective for treating cSCCs conserving epithelial traits, but resistance may occur in tumors with the E545K PIK3CA-activating mutation. Some initially responding tumors develop resistance after long-term treatment, induced by bypassing from EGFR signaling to FGFR signaling. Pharmacologic inhibition of FGFR signaling can overcome resistance to EGFR inhibitors.
CLINICAL CANCER RESEARCH
(2021)
Article
Genetics & Heredity
Xing Yi Woo, Jessica Giordano, Anuj Srivastava, Zi-Ming Zhao, Michael W. Lloyd, Roebi de Bruijn, Yun-Suhk Suh, Rajesh Patidar, Li Chen, Sandra Scherer, Matthew H. Bailey, Chieh-Hsiang Yang, Emilio Cortes-Sanchez, Yuanxin Xi, Jing Wang, Jayamanna Wickramasinghe, Andrew V. Kossenkov, Vito W. Rebecca, Hua Sun, R. Jay Mashl, Sherri R. Davies, Ryan Jeon, Christian Frech, Jelena Randjelovic, Jacqueline Rosains, Francesco Galimi, Andrea Bertotti, Adam Lafferty, Alice C. O'Farrell, Elodie Modave, Diether Lambrechts, Petra ter Brugge, Violeta Serra, Elisabetta Marangoni, Rania El Botty, Hyunsoo Kim, Jong-Il Kim, Han-Kwang Yang, Charles Lee, Dennis A. Dean, Brandi Davis-Dusenbery, Yvonne A. Evrard, James H. Doroshow, Alana L. Welm, Bryan E. Welm, Michael T. Lewis, Bingliang Fang, Jack A. Roth, Funda Meric-Bernstam, Meenhard Herlyn, Michael A. Davies, Li Ding, Shunqiang Li, Ramaswamy Govindan, Claudio Isella, Jeffrey A. Moscow, Livio Trusolino, Annette T. Byrne, Jos Jonkers, Carol J. Bult, Enzo Medico, Jeffrey H. Chuang
Summary: The analysis of copy number alterations in patient-derived xenografts (PDXs) and matched patient tumor samples reveals strong conservation of copy number alterations from patient tumors through late-passage PDXs, without systematic evolution driven by the mouse host. This suggests that PDX models are accurate in representing human cancer and that the mouse host does not significantly impact the copy number alterations during tumor evolution within the PDX model.
Article
Multidisciplinary Sciences
Clara Gomez-Aleza, Bastien Nguyen, Guillermo Yoldi, Marina Ciscar, Alexandra Barranco, Enrique Hernandez-Jimenez, Marion Maetens, Roberto Salgado, Maria Zafeiroglou, Pasquale Pellegrini, David Venet, Soizic Garaud, Eva M. Trinidad, Sandra Benitez, Peter Vuylsteke, Laura Polastro, Hans Wildiers, Philippe Simon, Geoffrey Lindeman, Denis Larsimont, Gert Van den Eynden, Chloe Velghe, Francoise Rothe, Karen Willard-Gallo, Stefan Michiels, Purificacion Munoz, Thierry Walzer, Lourdes Planelles, Josef Penninger, Hatem A. Azim, Sherene Loi, Martine Piccart, Christos Sotiriou, Eva Gonzalez-Suarez
NATURE COMMUNICATIONS
(2020)
Article
Cell Biology
Sandra Benitez, Alex Cordero, Patricia G. Santamaria, Jaime Redondo-Pedraza, Ana S. Rocha, Alejandro Collado-Sole, Maria Jimenez, Adrian Sanz-Moreno, Guillermo Yoldi, Juliana C. Santos, Ilaria De Benedictis, Clara Gomez-Aleza, Sabela Da Silva-Alvarez, Kevin Troule, Gonzalo Gomez-Lopez, Noelia Alcazar, Ignacio Palmero, Manuel Collado, Manuel Serrano, Eva Gonzalez-Suarez
Summary: Rank signaling enhances stemness and delays tumor initiation by inducing senescence in mammary epithelial cells, yet eventually promotes tumor progression and metastasis.
DEVELOPMENTAL CELL
(2021)
Article
Oncology
Adria Bernat-Peguera, Macedonia Trigueros, Angelica Ferrando-Diez, Cristina Ibanez, Sara Bystrup, Anna Martinez-Cardus, Mireia Margeli, Eva Martinez-Balibrea
Summary: The study shows that the combination of CT-P6 and pertuzumab with chemotherapy is equivalent to reference trastuzumab (RTZ) in treating early breast cancer patients, with no differences in efficacy or adverse events. Additionally, the use of CT-P6-based treatments reduces costs.
Meeting Abstract
Oncology
Andrea Vethencourt, Eva M. Trinidad, Anna Petit, Maria T. Soler-Monso, Clara Gomez Aleza, Ander Urruticochea, Amparo Garcia-Tejedor, Anna Guma Martinez, Veronica Obadia, Silvia Vazquez, Rafael Villanueva, Adela Fernanez, Monica Cejuela, Sabela Recalde Penabad, Agostina Stradella, Miguel Gil-Gil, Sonia Pernas, Eva Gonzalez-Suarez, Catalina Falo
Article
Oncology
Renee van Amerongen, Mohamed Bentires-Alj, Antonius L. L. van Boxtel, Robert B. B. Clarke, Silvia Fre, Eva Gonzalez Suarez, Richard Iggo, Martin Jechlinger, Jos Jonkers, Marja L. Mikkola, Zuzana Sumbalova Koledova, Therese Sorlie, Maria dM. Vivanco
Summary: On December 8, 2022, the ENBDC's organizing committee organized its fifth annual Think Tank meeting in Amsterdam, the Netherlands. The meeting aimed to review the most important breakthroughs of the past ten years and discuss the challenges that lie ahead in the field of mammary gland biology and breast cancer research. The outcomes of the discussions are presented in this position paper, with the hope of providing a summary for early career researchers and inspiring scientists and clinicians to advance the field.
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
(2023)
Article
Multidisciplinary Sciences
Ana Sofia Rocha, Alejandro Collado-Sole, Osvaldo Grana-Castro, Jaime Redondo-Pedraza, Gonzalo Soria-Alcaide, Alex Cordero, Patricia G. Santamaria, Eva Gonzalez-Suarez
Summary: The Rank signaling pathway plays a crucial role in mammary gland homeostasis and epithelial cell differentiation. Loss of luminal Rank leads to abnormal alveolar differentiation and lactation failure, which can be restored by activating bipotency in basal cells during subsequent pregnancies.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Adrian Sanz-Moreno, Sonia Palomeras, Kim Pedersen, Beatriz Morancho, Tomas Pascual, Patricia Galvan, Sandra Benitez, Jorge Gomez-Miragaya, Marina Ciscar, Maria Jimenez, Sonia Pernas, Anna Petit, Maria Teresa Soler-Monso, Gemma Vinas, Mansour Alsaleem, Emad A. Rakha, Andrew R. Green, Patricia G. Santamaria, Celine Mulder, Simone Lemeer, Joaquin Arribas, Aleix Prat, Teresa Puig, Eva Gonzalez-Suarez
Summary: The study found that RANK and RANKL proteins are more frequently detected in HER2-positive tumors that have acquired resistance to anti-HER2 therapies. After neoadjuvant therapy, RANK gene expression increased, and overactivation of the RANK signaling pathway enhanced ERK and NF-kappa B signaling, leading to increased resistance to lapatinib.
BREAST CANCER RESEARCH
(2021)