Article
Biochemistry & Molecular Biology
Yi Li, Yu-Fan Feng, Xiao-Tian Liu, Yu-Chen Li, Hui-Min Zhu, Meng-Ru Sun, Ping Li, Baolin Liu, Hua Yang
Summary: Songorine protects cardiac contractive function against endotoxin insult by activating Nrf2, suppressing mitochondrial reactive oxygen species production, and promoting mitochondrial biogenesis, ultimately enhancing cardioprotection.
Article
Chemistry, Multidisciplinary
Qingxia Huang, Hang Su, Bin Qi, Ying Wang, Kaili Yan, Xinglin Wang, Xiangyan Li, Daqing Zhao
Summary: The study confirms that ginsenoside Rc promotes the activity of SIRT1, leading to improved mitochondrial function and energy metabolism, thus enhancing cardio- and neuroprotective functions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Agriculture, Dairy & Animal Science
Wenjia Wang, Desheng Wu, Jinxue Ding, Jinli Wang, Jinwu Meng, Ke Ming, Siya Li, Tianxin Qin, Jiaguo Liu, Danchen Aaron Yang
Summary: The modified rougan decoction (MRGD) compound formula has been shown to have the ability to alleviate liver oxidant injury induced by lipopolysaccharide-enrofloxacin (LPS-ENR) in chickens. Recent research has focused on the impact of mitochondrial dysfunction on various diseases. The study investigated the effects of MRGD on mitochondrial structure and function using LPS-ENR-induced injury models in vivo and in vitro, and further explored its molecular mechanism.
Article
Pharmacology & Pharmacy
Weili Li, Jing Cao, Xiaoping Wang, Yawen Zhang, Qianbin Sun, Yanyan Jiang, Junkai Yao, Chun Li, Yong Wang, Wei Wang
Summary: The study demonstrated that Ferruginol (FGL) exerts cardioprotective effects by enhancing mitochondrial biogenesis and fatty acid oxidation through stimulating the SIRT1-PGC-1 alpha axis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Critical Care Medicine
Leijing Yin, Yuting Tang, Zhengyang Luo, Ludong Yuan, Xiaofang Lin, Shuxin Wang, Pengfei Liang, Bimei Jiang
Summary: The study aimed to investigate the protective role of nucleolin (NCL) in lipopolysaccharide (LPS)-induced myocardial injury from the aspect of mitochondrial biogenesis. The study found that NCL could protect cardiomyocytes from LPS-induced injury by promoting the gene expression of PGC-1a and mitochondrial biogenesis.
Article
Cell Biology
Shuai Zhang, Yuan Lu, Hong-Yu Jiang, Zhi-Mei Cheng, Zi-Jing Wei, Yun-Hao Wei, Ting Liu, Bai-Juan Xia, Xu-Ya Zhao, Yu Huang, Xun Zou, Rong Liu, Shi Zhou
Summary: CircC16orf62 acts as an oncogene in HCC progression, promoting cancer development through the miR-138-5p/PTK2/Akt pathway. It functions as a molecular sponge for miR-138-5p and a competitive endogenous RNA for PTK2, activating the AKT/mTOR pathway.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Yu-Kai Cui, Yi-Xiang Hong, Wei-Yin Wu, Wei-Min Han, Yao Wu, Chan Wu, Gui-Rong Li, Yan Wang
Summary: The study found that acacetin can reduce myocardial hypertrophy by activating the AMPK/PGC-1 alpha signaling pathway through Sirt1, which leads to a decrease in oxidation, inflammation, and apoptosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Xiaoguang Gu, Jianan Zhang, Yajuan Ran, Hena Pan, JinHong Jia, Ying Zhao, Xijuan Zhao, Wendi Li, Shasha Song, Xiufeng Yu
Summary: The study revealed the role of hsa_circ_101555 in HCC, potentially acting as a competing endogenous RNA for miR-145-5p to upregulate CDCA3 expression. Silencing hsa_circ_101555 significantly suppressed cell proliferation, migration, and invasion of HCC cells.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Ying Jiang, Da Li, Zhiqiang Du, Jie Li, Rongrong Lu, Qin Zhou, Qi Wang, Haohao Zhu
Summary: The study investigated the protective effects of Perampanel on mitochondrial biogenesis and bioenergetics in human neuronal cells. Results showed that Perampanel stimulated mitochondrial biogenesis and improved mitochondrial bioenergetics.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Dan Chen, Jing Guo, Longguang Li
Summary: This study demonstrates that catalpol has the potential to promote mitochondrial biogenesis and enhance mitochondrial function in chondrocytes, indicating its possible use in the treatment of joint diseases.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Biology
Yaqin Zhu, Yue Wang, Ying Li, Zhongqi Li, Wenhui Kong, Xiaoxuan Zhao, Shuting Chen, Liting Yan, Lenan Wang, Yunli Tong, Huanjie Shao
Summary: CPT1A regulates mitochondrial dynamics through succinylation of MFF to promote the growth and proliferation of ovarian cancer cells. High expression of MFF is associated with poor prognosis in ovarian cancer patients.
COMMUNICATIONS BIOLOGY
(2023)
Article
Cell Biology
Peng Ye, Wei Li, Xin Huang, Sheng Zhao, Wu Chen, Yuqi Xia, Weimin Yu, Ting Rao, Jinzhuo Ning, Xiangjun Zhou, Yuan Ruan, Fan Cheng
Summary: This study aimed to investigate the role and mechanism of BMAL1 in renal ischemia-reperfusion injury (IRI). The results showed that BMAL1 mediates mitochondrial homeostasis in renal IRI through the SIRT1/PGC-1 alpha axis, providing a new direction for targeted therapy for renal IRI.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Qiang Li, Jing Wu, Jiawen Huang, Rong Hu, Haiyan You, Lingyu Liu, Dongtao Wang, Lianbo Wei
Summary: This study demonstrated the significant improvement of paeoniflorin on CKD skeletal muscle atrophy by regulating the expression of proteins associated with muscle atrophy and muscle differentiation, modulating redox homeostasis, alleviating mitochondrial dysfunction, and upregulating the expression of AMPK/SIRT1/PGC-1α.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Abeer Elkhoely
Summary: The present study investigated the impact of liraglutide on gentamicin-induced kidney injury in rats. The results showed that liraglutide alleviated renal injury markers, oxidative stress, inflammation, and apoptosis. This study also revealed the involvement of mitochondrial biogenesis and its upstream regulators in the nephroprotective effects of liraglutide.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Ping Ren, Fangchao Gong, Liang Chang, Xiaodong Hong, Lei Xing, Hong Zhang
Summary: The study demonstrated that zafirlukast enhances mitochondrial function by promoting mitochondrial respiration and biogenesis in human bronchial epithelial cells. This effect is mediated through upregulation of PGC-1 alpha expression and activation of the CREB pathway.
JOURNAL OF MOLECULAR HISTOLOGY
(2021)