Prostate cancer promotes a vicious cycle of bone metastasis progression through inducing osteocytes to secrete GDF15 that stimulates prostate cancer growth and invasion

The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases

(2018) Vicky W.W. Tsai et al.   Cell Metabolism

Prostate cancer sheds the αvβ3 integrin in vivo through exosomes

(2018) Shiv Ram Krishn et al.   MATRIX BIOLOGY

Bone Microenvironment Changes in Latexin Expression Promote Chemoresistance

(2017) Mi Zhang et al.   MOLECULAR CANCER RESEARCH

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

(2017) Jer-Yuan Hsu et al.   NATURE

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

(2017) Linda Yang et al.   NATURE MEDICINE

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

(2017) Shannon E Mullican et al.   NATURE MEDICINE

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

(2017) Paul J Emmerson et al.   NATURE MEDICINE

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow

(2016) Regina Miftakhova et al.   CANCER RESEARCH

Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma

(2016) J. Delgado-Calle et al.   CANCER RESEARCH

Osteocytic connexin hemichannels suppress breast cancer growth and bone metastasis

(2016) J Z Zhou et al.   ONCOGENE

GRK2 overexpression inhibits IGF1-induced proliferation and migration of human hepatocellular carcinoma cells by downregulating EGR1

(2016) YANG MA et al.   ONCOLOGY REPORTS

Biology of Bone Metastases in Prostate Cancer

(2016) Janine Hensel et al.   UROLOGY

The Role of the Microenvironment in Prostate Cancer-Associated Bone Disease

(2016) Christina J. Turner et al.   Current Osteoporosis Reports

A Convenient In Vivo Model Using Small Interfering RNA Silencing to Rapidly Assess Skeletal Gene Function

(2016) Wen Zhang et al.   PLoS One

Tumor-Induced Pressure in the Bone Microenvironment Causes Osteocytes to Promote the Growth of Prostate Cancer Bone Metastases

(2015) Joseph L. Sottnik et al.   CANCER RESEARCH

Metastatic Prostate Cancer and the Bone: Significance and Therapeutic Options

(2015) Benjamin A. Gartrell et al.   EUROPEAN UROLOGY

Macrophage Inhibitory Cytokine 1 Biomarker Serum Immunoassay in Combination with PSA Is a More Specific Diagnostic Tool for Detection of Prostate Cancer

(2015) Ji Li et al.   PLoS One

Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15

(2014) F. Bruzzese et al.   CANCER RESEARCH

Recent advances in bone-targeted therapies of metastatic prostate cancer

(2014) Xiyun Deng et al.   CANCER TREATMENT REVIEWS

A Review of Osteocyte Function and the Emerging Importance of Sclerostin

(2014) Jocelyn T Compton et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Cabozantinib Inhibits Prostate Cancer Growth and Prevents Tumor-Induced Bone Lesions

(2013) Jinlu Dai et al.   CLINICAL CANCER RESEARCH

The Osteocyte: An Endocrine Cell … and More

(2013) Sarah L. Dallas et al.   ENDOCRINE REVIEWS

Increased expression of p21Waf1/Cip1 and JNK with costimulation of prostate cancer cell activation by an siRNA Egr-1 inhibitor

(2013) EDUARDO PARRA et al.   ONCOLOGY REPORTS

Sanguinarine induces apoptosis in human colorectal cancer HCT-116 cells through ROS-mediated Egr-1 activation and mitochondrial dysfunction

(2013) Min Ho Han et al.   TOXICOLOGY LETTERS

EGF activates TTP expression by activation of ELK-1 and EGR-1 transcription factors

(2012) Magdalena Florkowska et al.   BMC MOLECULAR BIOLOGY

In vitro and in vivo approaches to study osteocyte biology

(2012) Ivo Kalajzic et al.   BONE

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Heparin Inhibits Hepatocyte Growth Factor Induced Motility and Invasion of Hepatocellular Carcinoma Cells through Early Growth Response Protein 1

(2012) Evin Ozen et al.   PLoS One

Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15) Slows Cancer Development but Increases Metastases in TRAMP Prostate Cancer Prone Mice

(2012) Yasmin Husaini et al.   PLoS One

Growth/differentiation factor-15: prostate cancer suppressor or promoter?

(2012) P Vaňhara et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Positive regulation of osteoclastic differentiation by growth differentiation factor 15 upregulated in osteocytic cells under hypoxia

(2011) Eiichi Hinoi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Reversal of Chemotherapy-Induced Leukopenia Using Granulocyte Macrophage Colony-Stimulating Factor Promotes Bone Metastasis That Can Be Blocked with Osteoclast Inhibitors

(2010) Jinlu Dai et al.   CANCER RESEARCH

The amazing osteocyte

(2010) Lynda F Bonewald   JOURNAL OF BONE AND MINERAL RESEARCH

Transcription Factor Egr-1 Is Essential for Maximal Matrix Metalloproteinase-9 Transcription by Tumor Necrosis Factor  

(2010) S. Y. Shin et al.   MOLECULAR CANCER RESEARCH

Is EGR1 a potential target for prostate cancer therapy?

(2009) Delphine Gitenay et al.   Future Oncology

Targeted Knockdown of EGR-1 Inhibits IL-8 Production and IL-8-mediated Invasion of Prostate Cancer Cells through Suppressing EGR-1/NF-κB Synergy

(2009) Jiajia Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteocytes, mechanosensing and Wnt signaling

(2008) Lynda F. Bonewald et al.   BONE

Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip

(2008) Shilpi Arora et al.   GENOME BIOLOGY

Establishment of an Osteocyte-like Cell Line, MLO-Y4

(2006) Yoichi Kato et al.   JOURNAL OF BONE AND MINERAL RESEARCH