Inhibition of Karyopherin beta 1 suppresses prostate cancer growth

KPNA2 promotes migration and invasion in epithelial ovarian cancer cells by inducing epithelial-mesenchymal transition via Akt/GSK-3β/Snail activation

(2018) Long Huang et al.   Journal of Cancer

In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epithelial ovarian cancer

(2017) Michiko Kodama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Importin β1 targeting by hepatitis C virus NS3/4A protein restricts IRF3 and NF-κB signaling of IFNB1 antiviral response

(2017) Bridget Gagné et al.   TRAFFIC

Karyopherinβ1 regulates proliferation of human glioma cells via Wnt/β-catenin pathway

(2016) Ting Lu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential

(2016) Tamara Stelma et al.   IUBMB LIFE

Targeting the Nuclear Import Receptor Kpn 1 as an Anticancer Therapeutic

(2016) P. J. van der Watt et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of KPNA4 attenuates prostate cancer metastasis

(2016) J Yang et al.   ONCOGENE

Latcripin-13 domain induces apoptosis and cell cycle arrest at the G1 phase in human lung carcinoma A549 cells

(2016) JIA WANG et al.   ONCOLOGY REPORTS

Importins and exportins as therapeutic targets in cancer

(2016) Amit Mahipal et al.   PHARMACOLOGY & THERAPEUTICS

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

(2016) Amira Elgogary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myc and cell cycle control

(2015) Gabriel Bretones et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Hyper-dependence of breast cancer cell types on the nuclear transporter Importin β1

(2015) Henna V. Kuusisto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

KPNA2 is a nuclear export protein that contributes to aberrant localisation of key proteins and poor prognosis of breast cancer

(2015) A T Alshareeda et al.   BRITISH JOURNAL OF CANCER

Importin β1 mediates nuclear factor-κB signal transduction into the nuclei of myeloma cells and affects their proliferation and apoptosis

(2015) Wenqing Yan et al.   CELLULAR SIGNALLING

Karyopherin Alpha 2 Promotes the Inflammatory Response in Rat Pancreatic Acinar Cells Via Facilitating NF-κB Activation

(2015) Yongxia Cai et al.   DIGESTIVE DISEASES AND SCIENCES

KPNβ1 promotes palmitate-induced insulin resistance via NF-κB signaling in hepatocytes

(2015) Suxin Wang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Suppression of the nuclear transporter-KPNβ1 expression inhibits tumor proliferation in hepatocellular carcinoma

(2015) Linlin Yang et al.   MEDICAL ONCOLOGY

Antitumor effects of pharmacological EZH2 inhibition on malignant peripheral nerve sheath tumor through the miR-30a and KPNB1 pathway

(2015) Pingyu Zhang et al.   Molecular Cancer

Upregulation of miR-181s reverses mesenchymal transition by targeting KPNA4 in glioblastoma

(2015) Hongjun Wang et al.   Scientific Reports

Inhibition of the nuclear transporter, Kpnβ1, results in prolonged mitotic arrest and activation of the intrinsic apoptotic pathway in cervical cancer cells

(2014) Liselotte Angus et al.   CARCINOGENESIS

Prosurvival function of the cellular apoptosis susceptibility/importin-α1 transport cycle is repressed by p53 in liver cancer

(2014) Juliane Winkler et al.   HEPATOLOGY

Nuclear import and export inhibitors alter capsid protein distribution in mammalian cells and reduce Venezuelan Equine Encephalitis Virus replication

(2013) Lindsay Lundberg et al.   ANTIVIRAL RESEARCH

Nuclear karyopherin-α2 expression in primary lesions and metastatic lymph nodes was associated with poor prognosis and progression in gastric cancer

(2013) Bolag Altan et al.   CARCINOGENESIS

Metformin targets c-MYC oncogene to prevent prostate cancer

(2013) Tunde Akinyeke et al.   CARCINOGENESIS

Functional Genetic Screens Identify Genes Essential for Tumor Cell Survival in Head and Neck and Lung Cancer

(2013) S. R. Martens-de Kemp et al.   CLINICAL CANCER RESEARCH

KPNA7, a nuclear transport receptor, promotes malignant properties of pancreatic cancer cells in vitro

(2013) Eeva Laurila et al.   EXPERIMENTAL CELL RESEARCH

EZH2-miR-30d-KPNB1 pathway regulates malignant peripheral nerve sheath tumour cell survival and tumourigenesis

(2013) Pingyu Zhang et al.   JOURNAL OF PATHOLOGY

KPNA2 promotes cell proliferation and tumorigenicity in epithelial ovarian carcinoma through upregulation of c-Myc and downregulation of FOXO3a

(2013) L Huang et al.   Cell Death & Disease

Importazole, a Small Molecule Inhibitor of the Transport Receptor Importin-β

(2011) Jonathan F. Soderholm et al.   ACS Chemical Biology

Overexpression of Kpnβ1 and Kpnα2 Importin Proteins in Cancer Derives from Deregulated E2F Activity

(2011) Pauline J. van der Watt et al.   PLoS One

Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells

(2010) Michael H. A. Schmitz et al.   NATURE CELL BIOLOGY

The RCC1 superfamily: From genes, to function, to disease

(2008) Ouadah Hadjebi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis

(2008) Bora Gurel et al.   MODERN PATHOLOGY