Maleimide–thiol adducts stabilized through stretching

Experimentally realized mechanochemistry distinct from force-accelerated scission of loaded bonds

(2017) Sergey Akbulatov et al.   SCIENCE

Multi-modal mechanophores based on cinnamate dimers

(2017) Huan Zhang et al.   Nature Communications

Single Molecule Study of Force-Induced Rotation of Carbon–Carbon Double Bonds in Polymers

(2016) Wenmao Huang et al.   ACS Nano

Recent advances in the construction of antibody–drug conjugates

(2016) Vijay Chudasama et al.   Nature Chemistry

Polymer Mechanochemistry: From Destructive to Productive

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Inducing and quantifying forbidden reactivity with single-molecule polymer mechanochemistry

(2015) Junpeng Wang et al.   Nature Chemistry

A Remote Stereochemical Lever Arm Effect in Polymer Mechanochemistry

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Single Molecule Evidence for the Adaptive Binding of DOPA to Different Wet Surfaces

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Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates

(2014) Robert P Lyon et al.   NATURE BIOTECHNOLOGY

Defined Polymer-Peptide Conjugates to Form Cell-Instructive starPEG-Heparin Matrices In Situ

(2013) Mikhail V. Tsurkan et al.   ADVANCED MATERIALS

Polymer mechanochemistry: techniques to generate molecular force via elongational flows

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Methods for activating and characterizing mechanically responsive polymers

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The historical development of mechanochemistry

(2013) Laszlo Takacs   CHEMICAL SOCIETY REVIEWS

Recent progress in luminescent and colorimetric chemosensors for detection of thiols

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“Flex-Activated” Mechanophores: Using Polymer Mechanochemistry To Direct Bond Bending Activation

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Antibody-Drug Conjugates in Cancer Therapy

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Results of a Pivotal Phase II Study of Brentuximab Vedotin for Patients With Relapsed or Refractory Hodgkin's Lymphoma

(2012) Anas Younes et al.   JOURNAL OF CLINICAL ONCOLOGY

Bicyclo[3.2.0]heptane Mechanophores for the Non-scissile and Photochemically Reversible Generation of Reactive Bis-enones

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Tension Trapping of Carbonyl Ylides Facilitated by a Change in Polymer Backbone

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The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma

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Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

(2012) Ben-Quan Shen et al.   NATURE BIOTECHNOLOGY

Mechanically induced chemiluminescence from polymers incorporating a 1,2-dioxetane unit in the main chain

(2012) Yulan Chen et al.   Nature Chemistry

Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer

(2012) Sunil Verma et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reversible maleimide–thiol adducts yield glutathione-sensitive poly(ethylene glycol)–heparin hydrogels

(2012) Aaron D. Baldwin et al.   Polymer Chemistry

Maleimide Cross-Linked Bioactive PEG Hydrogel Exhibits Improved Reaction Kinetics and Cross-Linking for Cell Encapsulation and In Situ Delivery

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Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis

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Mechanically Induced Scission and Subsequent Thermal Remending of Perfluorocyclobutane Polymers

(2011) Hope M. Klukovich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct observation of disulfide isomerization in a single protein

(2011) Jorge Alegre-Cebollada et al.   Nature Chemistry

Thiol-Ene Click Chemistry

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Antibody–drug conjugates: targeted drug delivery for cancer

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Masked Cyanoacrylates Unveiled by Mechanical Force

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Brentuximab Vedotin (SGN-35) for Relapsed CD30-Positive Lymphomas

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Trapping a Diradical Transition State by Mechanochemical Polymer Extension

(2010) J. M. Lenhardt et al.   SCIENCE

Direct and Model Free Calculation of Force-Dependent Dissociation Rates from Force Spectroscopic Data

(2009) Leoni Oberbarnscheidt et al.   BIOPHYSICAL JOURNAL

Mechanically-Induced Chemical Changes in Polymeric Materials

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gem-Dichlorocyclopropanes as Abundant and Efficient Mechanophores in Polybutadiene Copolymers under Mechanical Stress

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Force-induced activation of covalent bonds in mechanoresponsive polymeric materials

(2009) Douglas A. Davis et al.   NATURE

Activating catalysts with mechanical force

(2009) Alessio Piermattei et al.   Nature Chemistry

A Simple and Practical Spreadsheet-Based Method to Extract Single-Molecule Dissociation Kinetics from Variable Loading-Rate Force Spectroscopy Data

(2008) Michael J. Serpe et al.   Journal of Physical Chemistry C

Highly Efficient Mechanochemical Scission of Silver-Carbene Coordination Polymers

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Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

(2008) Jagath R Junutula et al.   NATURE BIOTECHNOLOGY