Enhanced Liver Targeting of Camptothecin via Conjugation with Deoxycholic Acid

Penetration in 3D tumor spheroids and explants: Adding a further dimension to the structure-activity relationship of cell-penetrating peptides

(2018) Dirk van den Brand et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

3D cellular spheroids as tools for understanding carboxylated quantum dot behavior in tumors

(2018) Greta Jarockyte et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Length vs. stiffness: which plays a dominant role in the cellular uptake of fructose-based rod-like micelles by breast cancer cells in 2D and 3D cell culture models?

(2018) Jiacheng Zhao et al.   Journal of Materials Chemistry B

Two novel camptothecin derivatives inhibit colorectal cancer proliferation via induction of cell cycle arrest and apoptosis in vitro and in vivo

(2018) Hongzhi Du et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Transport of curcumin derivatives in Caco-2 cell monolayers

(2017) Zhen Zeng et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Development of nanostructured lipid carriers for the encapsulation and controlled release of vitamin D3

(2017) Sung Jin Park et al.   FOOD CHEMISTRY

Dimeric camptothecin-loaded RGD-modified targeted cationic polypeptide-based micelles with high drug loading capacity and redox-responsive drug release capability

(2017) Zhaopei Guo et al.   Biomaterials Science

Transporter-targeted cholic acid-cytarabine conjugates for improved oral absorption

(2016) Dong Zhang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Effective Enhancement of Hypoglycemic Effect of Insulin by Liver-Targeted Nanoparticles Containing Cholic Acid-Modified Chitosan Derivative

(2016) Zhe Zhang et al.   MOLECULAR PHARMACEUTICS

Enhanced hepatic-targeted delivery via oral administration using nanoliposomes functionalized with a novel DSPE–PEG–cholic acid conjugate

(2016) Ying Li et al.   RSC Advances

Synthesis and Evaluation of Bile Acid–Ribavirin Conjugates as Prodrugs to Target the Liver

(2015) Zhongqi Dong et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Perspectives on Biologically Active Camptothecin Derivatives

(2015) Ying-Qian Liu et al.   MEDICINAL RESEARCH REVIEWS

The effect of co-delivery of paclitaxel and curcumin by transferrin-targeted PEG-PE-based mixed micelles on resistant ovarian cancer in 3-D spheroids and in vivo tumors

(2014) Can Sarisozen et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Alkaloids from Coptis chinensis root promote glucose uptake in C2C12 myotubes

(2014) Te-Chun Yang et al.   FITOTERAPIA

Synthesis and in vitro evaluation of bile acid prodrugs of floxuridine to target the liver

(2014) Diana Vivian et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Polylactide Conjugates of Camptothecin with Different Drug Release Abilities

(2014) Ewa Oledzka et al.   MOLECULES

Synthesis and Biological Activity of Some Bile Acid-Based Camptothecin Analogues

(2014) Xingnuo Li et al.   MOLECULES

Anti-Proliferative and Apoptosis-Inducing Effects of Camptothecin-20(s)-O-(2-pyrazolyl-1)acetic Ester in Human Breast Tumor MCF-7 Cells

(2014) Chu Chu et al.   MOLECULES

A multicenter phase II study of belotecan, a new camptothecin analogue, in elderly patients with previously untreated, extensive-stage small cell lung cancer

(2013) Chang Dong Yeo et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Camptothecin inhibits platelet-derived growth factor-BB-induced proliferation of rat aortic vascular smooth muscle cells through inhibition of PI3K/Akt signaling pathway

(2013) Eun-Seok Park et al.   EXPERIMENTAL CELL RESEARCH

A liquid chromatography–tandem mass spectrometry method for pharmacokinetics and tissue distribution of a camptothecin quaternary derivative in rats

(2013) Qingyong Li et al.   FITOTERAPIA

Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway

(2012) Jui-Ling Hsu et al.   BIOCHEMICAL PHARMACOLOGY

Size-dependent absorption mechanism of polymeric nanoparticles for oral delivery of protein drugs

(2012) Chunbai He et al.   BIOMATERIALS

Bile acid transporters and regulatory nuclear receptors in the liver and beyond

(2012) Emina Halilbasic et al.   JOURNAL OF HEPATOLOGY

Novel liver-specific cholic acid-cytarabine conjugates with potent antitumor activities: Synthesis and biological characterization

(2011) Dan-qi Chen et al.   ACTA PHARMACOLOGICA SINICA

Synthesis and Anti – Tumour Activity of Novel Camptothecin – Bile Acid Analogues

(2011) Q.-Y. Li et al.   Letters in Drug Design & Discovery

Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery

(2009) Lichen Yin et al.   BIOMATERIALS