Development of the Mitochondrial Intermembrane Space Disulfide Relay Represents a Critical Step in Eukaryotic Evolution

ER stress-induced reactive oxygen species (ROS) are detrimental for the fitness of a thioredoxin reductase mutant

(2018) Paraskevi Kritsiligkou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How Are Proteins Reduced in the Endoplasmic Reticulum?

(2018) Lars Ellgaard et al.   TRENDS IN BIOCHEMICAL SCIENCES

Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species

(2018) Ulrike Topf et al.   Nature Communications

A single-cysteine mutant and chimeras of essential Leishmania Erv can complement the loss of Erv1 but not of Mia40 in yeast

(2018) Sandra Specht et al.   Redox Biology

An ER surface retrieval pathway safeguards the import of mitochondrial membrane proteins in yeast

(2018) Katja G. Hansen et al.   SCIENCE

Integrated genomic and fossil evidence illuminates life’s early evolution and eukaryote origin

(2018) Holly C. Betts et al.   Nature Ecology & Evolution

The Diverged Trypanosome MICOS Complex as a Hub for Mitochondrial Cristae Shaping and Protein Import

(2018) Iosif Kaurov et al.   CURRENT BIOLOGY

Endoplasmic Reticulum Transport of Glutathione by Sec61 Is Regulated by Ero1 and Bip

(2017) Alise J. Ponsero et al.   MOLECULAR CELL

Unconventional Targeting of a Thiol Peroxidase to the Mitochondrial Intermembrane Space Facilitates Oxidative Protein Folding

(2017) Paraskevi Kritsiligkou et al.   Cell Reports

Mitochondrial protein import: An unexpected disulfide bond

(2016) Dejana Mokranjac   JOURNAL OF CELL BIOLOGY

A disulfide bond in the TIM23 complex is crucial for voltage gating and mitochondrial protein import

(2016) Ajay Ramesh et al.   JOURNAL OF CELL BIOLOGY

Comprehensively Characterizing the Thioredoxin InteractomeIn VivoHighlights the Central Role Played by This Ubiquitous Oxidoreductase in Redox Control

(2016) Isabelle S. Arts et al.   MOLECULAR & CELLULAR PROTEOMICS

The Role of Charge in Protein Targeting Evolution

(2016) Sriram G. Garg et al.   TRENDS IN CELL BIOLOGY

Bacterial Vesicle Secretion and the Evolutionary Origin of the Eukaryotic Endomembrane System

(2016) Sven B. Gould et al.   TRENDS IN MICROBIOLOGY

The presence of disulfide bonds reveals an evolutionarily conserved mechanism involved in mitochondrial protein translocase assembly

(2016) Lidia Wrobel et al.   Scientific Reports

Mia40 is a trans-site receptor that drives protein import into the mitochondrial intermembrane space by hydrophobic substrate binding

(2016) Valentina Peleh et al.   eLife

Mia40 is a facile oxidant of unfolded reduced proteins but shows minimal isomerase activity

(2015) Devin A. Hudson et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Incidence and physiological relevance of protein thiol switches

(2015) Lars I. Leichert et al.   BIOLOGICAL CHEMISTRY

Thiol-based redox switches in prokaryotes

(2015) Melanie Hillion et al.   BIOLOGICAL CHEMISTRY

Thiol switches in mitochondria: operation and physiological relevance

(2015) Jan Riemer et al.   BIOLOGICAL CHEMISTRY

Mia40 Protein Serves as an Electron Sink in the Mia40-Erv1 Import Pathway

(2015) Sonya E. Neal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetic control by limiting glutaredoxin amounts enables thiol oxidation in the reducing mitochondrial intermembrane space

(2015) Kerstin Kojer et al.   MOLECULAR BIOLOGY OF THE CELL

Origin of eukaryotes from within archaea, archaeal eukaryome and bursts of gene gain: eukaryogenesis just made easier?

(2015) Eugene V. Koonin   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Thioredoxin Superfamily in Oxidative Protein Folding

(2014) Jun Lu et al.   ANTIOXIDANTS & REDOX SIGNALING

Mia40 Combines Thiol Oxidase and Disulfide Isomerase Activity to Efficiently Catalyze Oxidative Folding in Mitochondria

(2014) Johanna R. Koch et al.   JOURNAL OF MOLECULAR BIOLOGY

Mia40 targets cysteines in a hydrophobic environment to direct oxidative protein folding in the mitochondria

(2014) Johanna R. Koch et al.   Nature Communications

Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells

(2013) Manuel Fischer et al.   MOLECULAR BIOLOGY OF THE CELL

Glutathione redox potential in the mitochondrial intermembrane space is linked to the cytosol and impacts the Mia40 redox state

(2012) Kerstin Kojer et al.   EMBO JOURNAL

Atp23 biogenesis reveals a chaperone-like folding activity of Mia40 in the IMS of mitochondria

(2012) Daniel Weckbecker et al.   EMBO JOURNAL

Divergence of Erv1-Associated Mitochondrial Import and Export Pathways in Trypanosomes and Anaerobic Protists

(2012) Somsuvro Basu et al.   EUKARYOTIC CELL

Structure of Yeast Sulfhydryl Oxidase Erv1 Reveals Electron Transfer of the Disulfide Relay System in the Mitochondrial Intermembrane Space

(2012) Peng-Chao Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Small Tim Homohexamer in the Relict Mitochondrion of Cryptosporidium

(2011) Felicity Alcock et al.   MOLECULAR BIOLOGY AND EVOLUTION

Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR

(2011) L. Banci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The N-terminal Shuttle Domain of Erv1 Determines the Affinity for Mia40 and Mediates Electron Transfer to the Catalytic Erv1 Core in Yeast Mitochondria

(2010) Eirini Lionaki et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Disulfide Bond Formation Is Driven by Intersubunit Electron Transfer in Erv1 and Proofread by Glutathione

(2010) Melanie Bien et al.   MOLECULAR CELL

Molecular chaperone function of Mia40 triggers consecutive induced folding steps of the substrate in mitochondrial protein import

(2010) L. Banci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deciphering Structural and Functional Roles of Individual Disulfide Bonds of the Mitochondrial Sulfhydryl Oxidase Erv1p

(2009) Swee Kim Ang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel intermembrane space–targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding

(2009) Dionisia P. Sideris et al.   JOURNAL OF CELL BIOLOGY

Reconstitution of the Mia40-Erv1 Oxidative Folding Pathway for the Small Tim Proteins

(2009) Heather L. Tienson et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of the Signal Directing Tim9 and Tim10 into the Intermembrane Space of Mitochondria

(2009) Dusanka Milenkovic et al.   MOLECULAR BIOLOGY OF THE CELL

MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria

(2009) Lucia Banci et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of yeast Tim40/Mia40 as an oxidative translocator in the mitochondrial intermembrane space

(2009) S. Kawano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial protein import: precursor oxidation in a ternary complex with disulfide carrier and sulfhydryl oxidase

(2008) Diana Stojanovski et al.   JOURNAL OF CELL BIOLOGY