The Thioredoxin Superfamily in Oxidative Protein Folding

Targeting endoplasmic reticulum stress in metabolic disease

(2013) Stewart Siyan Cao et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The thioredoxin antioxidant system

(2013) Jun Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Thioredoxin System in Cell Death Progression

(2012) Jun Lu et al.   ANTIOXIDANTS & REDOX SIGNALING

Emerging Role of Protein-Protein Transnitrosylation in Cell Signaling Pathways

(2012) Tomohiro Nakamura et al.   ANTIOXIDANTS & REDOX SIGNALING

PRDX4, an Endoplasmic Reticulum-Localized Peroxiredoxin at the Crossroads Between Enzymatic Oxidative Protein Folding and Nonenzymatic Protein Oxidation

(2012) Ester Zito   ANTIOXIDANTS & REDOX SIGNALING

Understanding the pKa of Redox Cysteines: The Key Role of Hydrogen Bonding

(2012) Goedele Roos et al.   ANTIOXIDANTS & REDOX SIGNALING

Structural Insights into the Redox-Regulated Dynamic Conformations of Human Protein Disulfide Isomerase

(2012) Chao Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein Folding Drives Disulfide Formation

(2012) Pallav Kosuri et al.   CELL

Redox-sensitive YFP sensors monitor dynamic nuclear and cytosolic glutathione redox changes

(2012) Michèle Dardalhon et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Crystal Structure of the Protein-Disulfide Isomerase Family Member ERp27 Provides Insights into Its Substrate Binding Capabilities

(2012) Franz-Xaver Kober et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Balanced Ero1 activation and inactivation establishes ER redox homeostasis

(2012) Sunghwan Kim et al.   JOURNAL OF CELL BIOLOGY

Vitamin K epoxide reductase contributes to protein disulfide formation and redox homeostasis within the endoplasmic reticulum

(2012) Lori A. Rutkevich et al.   MOLECULAR BIOLOGY OF THE CELL

The dynamic disulphide relay of quiescin sulphydryl oxidase

(2012) Assaf Alon et al.   NATURE

Structure and Function of DsbA, a Key Bacterial Oxidative Folding Catalyst

(2011) Stephen R. Shouldice et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxides and Peroxidases in the Endoplasmic Reticulum: Integrating Redox Homeostasis and Oxidative Folding

(2011) Taichi Kakihana et al.   ANTIOXIDANTS & REDOX SIGNALING

Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4

(2011) Xi Wang et al.   BIOCHEMICAL JOURNAL

Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics and neuronal synaptic damage in neurodegenerative diseases

(2011) T Nakamura et al.   CELL DEATH AND DIFFERENTIATION

Glutathione revisited: a vital function in iron metabolism and ancillary role in thiol-redox control

(2011) Chitranshu Kumar et al.   EMBO JOURNAL

Crystal Structure of Reduced and of Oxidized Peroxiredoxin IV Enzyme Reveals a Stable Oxidized Decamer and a Non-disulfide-bonded Intermediate in the Catalytic Cycle

(2011) Zhenbo Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutathione- and non-glutathione-based oxidant control in the endoplasmic reticulum

(2011) C. Appenzeller-Herzog   JOURNAL OF CELL SCIENCE

Two Endoplasmic Reticulum PDI Peroxidases Increase the Efficiency of the Use of Peroxide during Disulfide Bond Formation

(2011) Van Dat Nguyen et al.   JOURNAL OF MOLECULAR BIOLOGY

Single-molecule paleoenzymology probes the chemistry of resurrected enzymes

(2011) Raul Perez-Jimenez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Oxidative Protein Folding and the Quiescin–Sulfhydryl Oxidase Family of Flavoproteins

(2010) Vamsi K. Kodali et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox compartmentalization and cellular stress

(2010) D. P. Jones et al.   DIABETES OBESITY & METABOLISM

Recycling of peroxiredoxin IV provides a novel pathway for disulphide formation in the endoplasmic reticulum

(2010) Timothy J Tavender et al.   EMBO JOURNAL

Disulphide production by Ero1α–PDI relay is rapid and effectively regulated

(2010) Christian Appenzeller-Herzog et al.   EMBO JOURNAL

Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDI

(2010) Kenji Inaba et al.   EMBO JOURNAL

Oxidative Activity of Yeast Ero1p on Protein Disulfide Isomerase and Related Oxidoreductases of the Endoplasmic Reticulum

(2010) Elvira Vitu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Reduction Potential of the Active Site Disulfides of Human Protein Disulfide Isomerase Limits Oxidation of the Enzyme by Ero1α

(2010) Joseph E. Chambers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative Protein Folding by an Endoplasmic Reticulum-Localized Peroxiredoxin

(2010) Ester Zito et al.   MOLECULAR CELL

Structure of a bacterial homologue of vitamin K epoxide reductase

(2010) Weikai Li et al.   NATURE

Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners

(2010) S. Schulman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMR structure of oxidized Escherichia coli glutaredoxin: Comparison with reduced E. coli glutaredoxin and functionally related proteins

(2010) Tai-He Xia et al.   PROTEIN SCIENCE

Protein Disulfide Isomerase: A Critical Evaluation of Its Function in Disulfide Bond Formation

(2009) Feras Hatahet et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins

(2009) C. E. Jessop et al.   JOURNAL OF CELL SCIENCE

DSB proteins and bacterial pathogenicity

(2009) Begoña Heras et al.   NATURE REVIEWS MICROBIOLOGY

Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy

(2009) Raul Perez-Jimenez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An Atlas of the Thioredoxin Fold Class Reveals the Complexity of Function-Enabling Adaptations

(2009) Holly J. Atkinson et al.   PLoS Computational Biology

Evolutionary and Structural Insights Into the Multifaceted Glutathione Peroxidase (Gpx) Superfamily

(2008) Stefano Toppo et al.   ANTIOXIDANTS & REDOX SIGNALING

Kinetic and Thermodynamic Aspects of Cellular Thiol–Disulfide Redox Regulation

(2008) Kristine Steen Jensen et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox compartmentalization in eukaryotic cells

(2008) Young-Mi Go et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A novel disulphide switch mechanism in Ero1α balances ER oxidation in human cells

(2008) Christian Appenzeller-Herzog et al.   EMBO JOURNAL

Low reduction potential of Ero1α regulatory disulphides ensures tight control of substrate oxidation

(2008) Karl M Baker et al.   EMBO JOURNAL

The Catalytic Activity of Protein-disulfide Isomerase Requires a Conformationally Flexible Molecule

(2008) Geng Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Redox Environment in the Mitochondrial Intermembrane Space Is Maintained Separately from the Cytosol and Matrix

(2008) Jingjing Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thermodynamic Aspects of DsbD-Mediated Electron Transport

(2008) Anna Rozhkova et al.   JOURNAL OF MOLECULAR BIOLOGY

Nonequilibrium thermodynamics of thiol/disulfide redox systems: A perspective on redox systems biology

(2007) Melissa Kemp et al.   FREE RADICAL BIOLOGY AND MEDICINE