The endothelial lectin clearance receptor CLEC4M binds and internalizes factor VIII in a VWF-dependent and independent manner

N-linked glycosylation modulates the immunogenicity of recombinant human factor VIII in hemophilia A mice.

(2018) Jesse D Lai et al.   HAEMATOLOGICA

Early cellular interactions and immune transcriptome profiles in human factor VIII-exposed hemophilia A mice

(2018) J. D. Lai et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

In-depth comparison of N -glycosylation of human plasma-derived factor VIII and different recombinant products: from structure to clinical implications

(2018) K. Canis et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

N-linked glycosylation modulates the immunogenicity of recombinant human factor VIII in hemophilia A mice.

(2018) Jesse D Lai et al.   HAEMATOLOGICA

The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity

(2018) Laura L. Swystun et al.   JOURNAL OF CLINICAL INVESTIGATION

Life in the shadow of a dominant partner: the FVIII-VWF association and its clinical implications for hemophilia A

(2016) S. W. Pipe et al.   BLOOD

Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF

(2015) J. E. Huffman et al.   BLOOD

CLEC4MandSTXBP5gene variations contribute to von Willebrand factor level variation in von Willebrand disease

(2015) Y. V. Sanders et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

FcRn Rescues Recombinant Factor VIII Fc Fusion Protein from a VWF Independent FVIII Clearance Pathway in Mouse Hepatocytes

(2015) Arjan van der Flier et al.   PLoS One

A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII

(2014) S. A. Fahs et al.   BLOOD

Murine coagulation factor VIII is synthesized in endothelial cells

(2014) L. A. Everett et al.   BLOOD

The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels

(2013) N. Rydz et al.   BLOOD

Hemophilia: In Review

(2013) B. Zimmerman et al.   PEDIATRICS IN REVIEW

Mapping the N-glycome of human von Willebrand factor

(2012) Kevin Canis et al.   BIOCHEMICAL JOURNAL

Macrophage LRP1 contributes to the clearance of von Willebrand factor

(2012) G. Rastegarlari et al.   BLOOD

Elevated factor VIII levels and risk of venous thrombosis

(2012) P. Vince Jenkins et al.   BRITISH JOURNAL OF HAEMATOLOGY

Factor VIII and von Willebrand factor are ligands for the carbohydrate-receptor Siglec-5

(2012) J. N. Pegon et al.   HAEMATOLOGICA

In vitro and in vivo evaluation of the effect of elevated factor VIII on the thrombogenic process

(2012) M. Golder et al.   THROMBOSIS AND HAEMOSTASIS

Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels

(2011) Guillemette Antoni et al.   BMC Medical Genetics

Uptake of blood coagulation factor VIII by dendritic cells is mediated via its C1 domain

(2011) Eszter Herczenik et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Novel Associations of Multiple Genetic Loci With Plasma Levels of Factor VII, Factor VIII, and von Willebrand Factor

(2010) Nicholas L. Smith et al.   CIRCULATION

Factor VIII and von Willebrand factor - too sweet for their own good

(2010) P. J. LENTING et al.   HAEMOPHILIA

Splenic marginal zone antigen-presenting cells are critical for the primary allo-immune response to therapeutic factor VIII in hemophilia A

(2009) A. NAVARRETE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

DC-SIGN and L-SIGN: the SIGNs for infection

(2008) Ui-Soon Khoo et al.   JOURNAL OF MOLECULAR MEDICINE-JMM