Silymarin and silymarin nanoparticles guard against chronic unpredictable mild stress induced depressive-like behavior in mice: involvement of neurogenesis and NLRP3 inflammasome

Anxiolytic- and antidepressant-like effects of Silymarin compared to diazepam and fluoxetine in a mouse model of mild traumatic brain injury

(2018) Morteza Kosari-Nasab et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The potential antidepressant action and adverse effects profile of scopolamine co-administered with the mGlu7 receptor allosteric agonist AMN082 in mice

(2018) Karolina Podkowa et al.   NEUROPHARMACOLOGY

Cancer nanotheranostics: A review of the role of conjugated ligands for overexpressed receptors

(2017) Lydia Ramzy et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Senegenin exerts anti-depression effect in mice induced by chronic un-predictable mild stress via inhibition of NF-κB regulating NLRP3 signal pathway

(2017) Hongwei Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Improving intestinal absorption and oral bioavailability of curcumin via taurocholic acid-modified nanostructured lipid carriers

(2017) Cihui Tian et al.   International Journal of Nanomedicine

Leonurine Exerts Antidepressant-Like Effects in the Chronic Mild Stress-Induced Depression Model in Mice by Inhibiting Neuroinflammation

(2017) Miaomiao Jia et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Antidepressant-like effect of gallic acid in mice: Dual involvement of serotonergic and catecholaminergic systems

(2017) Özgür Devrim Can et al.   LIFE SCIENCES

Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response

(2017) Vishnu N. Thakare et al.   PHYSIOLOGY & BEHAVIOR

The involvement of monoaminergic neurotransmission in the antidepressant-like action of scopolamine in the tail suspension test

(2017) Agnieszka Pałucha-Poniewiera et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Saikosaponin D relieves unpredictable chronic mild stress induced depressive-like behavior in rats: involvement of HPA axis and hippocampal neurogenesis

(2017) Hong-Yan Li et al.   PSYCHOPHARMACOLOGY

Chronic treatment with caffeine and its withdrawal modify the antidepressant-like activity of selective serotonin reuptake inhibitors in the forced swim and tail suspension tests in mice. Effects on Comt , Slc6a15 and Adora1 gene expression

(2017) Aleksandra Szopa et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Lipids-based nanostructured lipid carriers (NLCs) for improved oral bioavailability of sirolimus

(2016) Qin Yu et al.   DRUG DELIVERY

Nebulizable colloidal nanoparticles co-encapsulating a COX-2 inhibitor and a herbal compound for treatment of lung cancer

(2016) Ramy Said-Elbahr et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPARγ-mediated alteration of microglial activation phenotypes

(2016) Qiuying Zhao et al.   Journal of Neuroinflammation

Neurodevelopmental Animal Models Reveal the Convergent Role of Neurotransmitter Systems, Inflammation, and Oxidative Stress as Biomarkers of Schizophrenia: Implications for Novel Drug Development

(2015) M. Möller et al.   ACS Chemical Neuroscience

TNF-alpha inhibition prevents cognitive decline and maintains hippocampal BDNF levels in the unpredictable chronic mild stress rat model of depression

(2015) Tuğçe Demirtaş Şahin et al.   BEHAVIOURAL BRAIN RESEARCH

Thymol produces an antidepressant-like effect in a chronic unpredictable mild stress model of depression in mice

(2015) Xue-Yang Deng et al.   BEHAVIOURAL BRAIN RESEARCH

Silymarin Extends Lifespan and Reduces Proteotoxicity in C. elegans Alzheimer’s Model

(2015) Jitendra Kumar et al.   CNS & Neurological Disorders-Drug Targets

Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery

(2015) Maha Nasr   DRUG DELIVERY

Recent advances in topical formulation carriers of antifungal agents

(2015) EmanAhmed Bseiso et al.   Indian Journal of Dermatology Venereology & Leprology

Icariin exerts an antidepressant effect in an unpredictable chronic mild stress model of depression in rats and is associated with the regulation of hippocampal neuroinflammation

(2015) B. Liu et al.   NEUROSCIENCE

Chronic unpredictable mild stress decreases BDNF and NGF levels and Na+,K+-ATPase activity in the hippocampus and prefrontal cortex of mice: Antidepressant effect of chrysin

(2015) C.B. Filho et al.   NEUROSCIENCE

l-Menthone confers antidepressant-like effects in an unpredictable chronic mild stress mouse model via NLRP3 inflammasome-mediated inflammatory cytokines and central neurotransmitters

(2015) Jinsong Xue et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Improved oral bioavailability of docetaxel by nanostructured lipid carriers: in vitro characteristics, in vivo evaluation and intestinal transport studies

(2015) Guihua Fang et al.   RSC Advances

Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in rats

(2014) Dexiang Liu et al.   BEHAVIOURAL BRAIN RESEARCH

Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats

(2014) Ying Pan et al.   BRAIN BEHAVIOR AND IMMUNITY

Iptakalim confers an antidepressant effect in a chronic mild stress model of depression through regulating neuro-inflammation and neurogenesis

(2014) Ming Lu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Silibinin Attenuates MPP+-Induced Neurotoxicity in the Substantia Nigra In Vivo

(2014) Un Ju Jung et al.   JOURNAL OF MEDICINAL FOOD

BDNF in late-life depression: Effect of SSRI usage and interaction with childhood abuse

(2014) Annemarie van der Meij et al.   PSYCHONEUROENDOCRINOLOGY

Neuroprotective effect of silymarin in a MPTP mouse model of Parkinson's disease

(2014) Jesús Pérez-H et al.   TOXICOLOGY

Vitamin C and silymarin restores beta-amyloid oligomerization and behavioral abnormality in Alzheimer's disease pathology

(2013) Kazuma Murakami et al.   Alzheimers & Dementia

Involvement of Inflammasome Activation in Lipopolysaccharide-induced Mice Depressive-like Behaviors

(2013) Yi Zhang et al.   CNS Neuroscience & Therapeutics

Nanostructured lipid carriers (NLC): A potential delivery system for bioactive food molecules

(2013) Fardin Tamjidi et al.   Innovative Food Science & Emerging Technologies

Binary lipids-based nanostructured lipid carriers for improved oral bioavailability of silymarin

(2013) Mingzhu Shangguan et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Amelioration of cognitive, motor and endogenous defense functions with silymarin, piracetam and protocatechuic acid in the cerebral global ischemic rat model

(2013) Milind M. Muley et al.   LIFE SCIENCES

Pre-treatment with silymarin reduces brain myeloperoxidase activity and inflammatory cytokines in 6-OHDA hemi-parkinsonian rats

(2013) Rasool Haddadi et al.   NEUROSCIENCE LETTERS

Impact of inflammation on neurotransmitter changes in major depression: An insight into the action of antidepressants

(2013) Brian E. Leonard   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses

(2012) Masaaki Iwata et al.   BRAIN BEHAVIOR AND IMMUNITY

Amphotericin B lipid nanoemulsion aerosols for targeting peripheral respiratory airways via nebulization

(2012) Maha Nasr et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Silymarin improves the behavioural, biochemical and histoarchitecture alterations in focal ischemic rats: A comparative evaluation with piracetam and protocatachuic acid

(2012) Milind M. Muley et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Psychological Characteristics of Chronic Depression

(2011) Jenneke E. Wiersma et al.   JOURNAL OF CLINICAL PSYCHIATRY

Ascorbic acid treatment, similarly to fluoxetine, reverses depressive-like behavior and brain oxidative damage induced by chronic unpredictable stress

(2011) Morgana Moretti et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Neuroprotective effect of silibinin in diabetic mice

(2011) Giuseppina Marrazzo et al.   NEUROSCIENCE LETTERS

Long-term treatment with peony glycosides reverses chronic unpredictable mild stress-induced depressive-like behavior via increasing expression of neurotrophins in rat brain

(2010) Qing-Qiu Mao et al.   BEHAVIOURAL BRAIN RESEARCH

Neuroprotective effect of silymarin in 6-hydroxydopamine hemi-parkinsonian rat: Involvement of estrogen receptors and oxidative stress

(2010) Tourandokht Baluchnejadmojarad et al.   NEUROSCIENCE LETTERS

Association between Repeated Unpredictable Chronic Mild Stress (UCMS) Procedures with a High Fat Diet: A Model of Fluoxetine Resistance in Mice

(2010) Elsa Isingrini et al.   PLoS One

In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression

(2010) Marta Kubera et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Neuropsychopharmacological effect of sesamol in unpredictable chronic mild stress model of depression: behavioral and biochemical evidences

(2010) Baldeep Kumar et al.   PSYCHOPHARMACOLOGY

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Silibinin prevents amyloid β peptide-induced memory impairment and oxidative stress in mice

(2009) P Lu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Solid lipid nanoparticles: A modern formulation approach in drug delivery system

(2009) S Mukherjee et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes

(2008) Mohit Kumar Bhutani et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR