Tanshinone IIA protects against lipopolysaccharide-induced lung injury through targeting Sirt1

Acute downregulation of miR-199a attenuates sepsis-induced acute lung injury by targeting SIRT1

(2018) Yang Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Anti-inflammatory effect of stem bark of Paulownia tomentosa Steud. in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and LPS-induced murine model of acute lung injury

(2018) Jae-Won Lee et al.   JOURNAL OF ETHNOPHARMACOLOGY

Tanshinone IIA alleviates lipopolysaccharide-induced acute lung injury by downregulating TRPM7 and pro-inflammatory factors

(2017) Jie Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1)

(2017) Jie Peng et al.   Oncotarget

Tanshinone II A Attenuates TNF-α-Induced Expression of VCAM-1 and ICAM-1 in Endothelial Progenitor Cells by Blocking Activation of NF-κB

(2016) Jin-Xiu Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Dexamethasone Attenuates LPS-induced Acute Lung Injury through Inhibition of NF-κB, COX-2, and Pro-inflammatory Mediators

(2016) Naif O. Al-Harbi et al.   IMMUNOLOGICAL INVESTIGATIONS

Resveratrol alleviates sepsis-induced myocardial injury in rats by suppressing neutrophil accumulation, the induction of TNF-α and myocardial apoptosis via activation of Sirt1

(2016) Rui An et al.   Molecular Medicine Reports

SIRT1/3 Activation by Resveratrol Attenuates Acute Kidney Injury in a Septic Rat Model

(2016) Siqi Xu et al.   Oxidative Medicine and Cellular Longevity

PHARMACOLOGICAL SIRT1 ACTIVATION IMPROVES MORTALITY AND MARKEDLY ALTERS TRANSCRIPTIONAL PROFILES THAT ACCOMPANY EXPERIMENTAL SEPSIS

(2016) Steven M. Opal et al.   SHOCK

Rescue therapy with Tanshinone IIA hinders transition of acute kidney injury to chronic kidney disease via targeting GSK3β

(2016) Chunming Jiang et al.   Scientific Reports

Sirt1 restrains lung inflammasome activation in a murine model of sepsis

(2015) Rong Gao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Trimetazidine prevents macrophage-mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1

(2015) Jing Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Tanshinone IIA attenuates cardiac dysfunction in endotoxin-induced septic mice via inhibition of NADPH oxidase 2-related signaling pathway

(2015) Libing Huang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules inob/obmice

(2015) Xianfeng Wang et al.   Obesity

Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia

(2015) Jung Seok Hwang et al.   Scientific Reports

Tanshinone IIA therapeutically reduces LPS-induced acute lung injury by inhibiting inflammation and apoptosis in mice

(2014) Min Xu et al.   ACTA PHARMACOLOGICA SINICA

PCSK9 is a critical regulator of the innate immune response and septic shock outcome

(2014) K. R. Walley et al.   Science Translational Medicine

Interferon β protects against lethal endotoxic and septic shock through SIRT1 upregulation

(2014) Chae-Hwa Yoo et al.   Scientific Reports

The Effect of Sodium Tanshinone IIA Sulfate and Simvastatin on Elevated Serum Levels of Inflammatory Markers in Patients with Coronary Heart Disease: A Study Protocol for a Randomized Controlled Trial

(2013) Qinghua Shang et al.   Evidence-based Complementary and Alternative Medicine

Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway

(2013) Jieming Ye et al.   NEUROSCIENCE LETTERS

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes

(2012) M.-H. Moon et al.   OSTEOARTHRITIS AND CARTILAGE

Neuroprotection of Tanshinone IIA against Cerebral Ischemia/Reperfusion Injury through Inhibition of Macrophage Migration Inhibitory Factor in Rats

(2012) Yanlin Chen et al.   PLoS One

SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity

(2012) Hongying Yang et al.   PLoS One

Cardiovascular actions and therapeutic potential of tanshinone IIA

(2011) Si Gao et al.   ATHEROSCLEROSIS

Tanshinone IIA Attenuates Seawater Aspiration-Induced Lung Injury by Inhibiting Macrophage Migration Inhibitory Factor

(2011) Yong Zhang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Lung injury induced by sepsis: lessons learned from large animal models and future directions for treatment

(2011) Benjamin Sadowitz et al.   Expert Review of Anti-Infective Therapy

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Tanshinone II A attenuates inflammatory responses of rats with myocardial infarction by reducing MCP-1 expression

(2009) Z.H. Ren et al.   PHYTOMEDICINE

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

Low-dose dexamethasone alleviates lipopolysaccharide-induced acute lung injury in rats and upregulates pulmonary glucocorticoid receptors

(2008) Xiao-Qiu WANG et al.   RESPIROLOGY