Loss of NF-κB p50 function synergistically augments microglial priming in the middle-aged brain

NFKB1: a suppressor of inflammation, ageing and cancer

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Microglia Priming with Aging and Stress

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Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage

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Loss of Nfkb1 leads to early onset aging

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Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas lpr/lpr mutant mice

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Nfkb1/p50 and mammalian aging

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Accelerated microglial pathology is associated with Aβ plaques in mouse models of Alzheimer's disease

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Oxidative stress, redox signalling and endothelial dysfunction in ageing-related neurodegenerative diseases: a role of NADPH oxidase 2

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Redox regulation of NF-κB p50 and M1 polarization in microglia

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Early release of high-mobility group box 1 (HMGB1) from neurons in experimental subarachnoid hemorrhage in vivo and in vitro

(2014) Qing Sun et al.   Journal of Neuroinflammation

The impact of single and pairwise Toll-like receptor activation on neuroinflammation and neurodegeneration

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Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Priming of microglia in a DNA-repair deficient model of accelerated aging

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Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration

(2013) Liya Qin et al.   GLIA

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Age and duration of inflammatory environment differentially affect the neuroimmune response and catecholaminergic neurons in the midbrain and brainstem

(2013) Isabelle Bardou et al.   NEUROBIOLOGY OF AGING

Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit

(2013) Taisia Rolova et al.   NEUROBIOLOGY OF DISEASE

Microglia: Scapegoat, Saboteur, or Something Else?

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Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration

(2013) V. Hugh Perry et al.   Seminars in Immunopathology

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

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Oxidative Stress in Neurodegenerative Diseases and Ageing

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Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice

(2011) Ashley M. Fenn et al.   BRAIN BEHAVIOR AND IMMUNITY

Traumatic Brain Injury in Adult Rats Causes Progressive Nigrostriatal Dopaminergic Cell Loss and Enhanced Vulnerability to the Pesticide Paraquat

(2011) Che Brown Hutson et al.   JOURNAL OF NEUROTRAUMA

NF-κB is 25

(2011) David Baltimore   NATURE IMMUNOLOGY

Crosstalk in NF-κB signaling pathways

(2011) Andrea Oeckinghaus et al.   NATURE IMMUNOLOGY

Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge

(2010) Angela M. Wynne et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial activation in healthy aging

(2010) Alie Schuitemaker et al.   NEUROBIOLOGY OF AGING

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

Dopaminergic and serotoninergic deficiencies in young adult rats prenatally exposed to the bacterial lipopolysaccharide

(2009) Sabrina Wang et al.   BRAIN RESEARCH

Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activationin vivoandin vitro

(2009) Anthony Lyons et al.   JOURNAL OF NEUROCHEMISTRY

Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders

(2009) Rommy von Bernhardi et al.   JOURNAL OF NEUROCHEMISTRY

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor  B

(2009) C. Porta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NF- B in the Nervous System

(2009) B. Kaltschmidt et al.   Cold Spring Harbor Perspectives in Biology

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

(2008) Christopher J. Henry et al.   BRAIN BEHAVIOR AND IMMUNITY

Nuclear factor-κB1: Regulation and function

(2007) Silvia Gaspar Pereira et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY