Utilization of the CRISPR-Cas9 Gene Editing System to Dissect Neuroinflammatory and Neuropharmacological Mechanisms in Parkinson’s Disease

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells

(2019) Souvarish Sarkar et al.   Science Signaling

Mechanistic Interplay between Autophagy and Apoptotic Signaling in Endosulfan-induced Dopaminergic Neurotoxicity: Relevance to the Adverse Outcome Pathway in Pesticide Neurotoxicity

(2019) Chunjuan Song et al.   TOXICOLOGICAL SCIENCES

Mechanisms of TFAM-mediated cardiomyocyte protection

(2018) George H. Kunkel et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Gene therapy for sickle cell disease: An update

(2018) Selami Demirci et al.   CYTOTHERAPY

Delivering CRISPR: a review of the challenges and approaches

(2018) Christopher A. Lino et al.   DRUG DELIVERY

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

(2018) Megan F. Duffy et al.   Journal of Neuroinflammation

Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events

(2018) Neeraj Singh et al.   NEUROBIOLOGY OF DISEASE

Manganese exposure exacerbates progressive motor deficits and neurodegeneration in the MitoPark mouse model of Parkinson’s disease: Relevance to gene and environment interactions in metal neurotoxicity

(2018) Monica R. Langley et al.   NEUROTOXICOLOGY

Fatigue in Parkinson's disease: concepts and clinical approach

(2018) Daniel V. Nassif et al.   Psychogeriatrics

Fatigue in Parkinson's disease: concepts and clinical approach

(2018) Daniel V. Nassif et al.   Psychogeriatrics

CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease

(2018) Bence György et al.   Molecular Therapy-Nucleic Acids

Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes

(2018) Matthew Neal et al.   GLIA

Application of CRISPR/Cas9 technologies combined with iPSCs in the study and treatment of retinal degenerative diseases

(2018) Bincui Cai et al.   HUMAN GENETICS

Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury

(2018) Zhe Gong et al.   Journal of Neuroinflammation

Loss of Microglial Parkin Inhibits Necroptosis and Contributes to Neuroinflammation

(2018) Pedro Elói Antunes Dionísio et al.   MOLECULAR NEUROBIOLOGY

CRISPR/Cas9-Mediated Generation of Guangxi Bama Minipigs Harboring Three Mutations in α-Synuclein Causing Parkinson’s Disease

(2018) Xiang-Xing Zhu et al.   Scientific Reports

Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated deletion of the SNCA gene

(2018) Yixi Chen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

CRISPR-baby scientist fails to satisfy critics

(2018) David Cyranoski   NATURE

CRISPR-Cas9 Mediated Telomere Removal Leads to Mitochondrial Stress and Protein Aggregation

(2017) Hyojung Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation

(2017) Sylvia Torres-Odio et al.   Journal of Neuroinflammation

Randomized CRISPR-Cas Transcriptional Perturbation Screening Reveals Protective Genes against Alpha-Synuclein Toxicity

(2017) Ying-Chou Chen et al.   MOLECULAR CELL

Identification of essential genes for cancer immunotherapy

(2017) Shashank J. Patel et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

A CRISPR screen identifies a pathway required for paraquat-induced cell death

(2017) Colleen R Reczek et al.   Nature Chemical Biology

Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy

(2017) Christoph Potting et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease

(2017) Gargi Ganguly et al.   Drug Design Development and Therapy

A novel tool for monitoring endogenous alpha-synuclein transcription by NanoLuciferase tag insertion at the 3′end using CRISPR-Cas9 genome editing technique

(2017) Sambuddha Basu et al.   Scientific Reports

Parkinson's disease: Autoimmunity and neuroinflammation

(2016) Armando De Virgilio et al.   AUTOIMMUNITY REVIEWS

The Heroes of CRISPR

(2016) Eric S. Lander   CELL

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson’s Disease

(2016) Anamitra Ghosh et al.   Journal of Neuroimmune Pharmacology

Mutations in TFAM, encoding mitochondrial transcription factor A, cause neonatal liver failure associated with mtDNA depletion

(2016) Ashlee R. Stiles et al.   MOLECULAR GENETICS AND METABOLISM

Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9

(2016) Dominik Paquet et al.   NATURE

From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery

(2016) William A. Banks   NATURE REVIEWS DRUG DISCOVERY

Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration

(2016) Richard Gordon et al.   Nature Communications

One-step generation of triple gene-targeted pigs using CRISPR/Cas9 system

(2016) Xianlong Wang et al.   Scientific Reports

CNS-restricted Transduction and CRISPR/Cas9-mediated Gene Deletion with an Engineered AAV Vector

(2016) Giridhar Murlidharan et al.   Molecular Therapy-Nucleic Acids

Relationships Between Mitochondria and Neuroinflammation: Implications for Alzheimer's Disease

(2015) Heather M. Wilkins et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Expanding the Biologist’s Toolkit with CRISPR-Cas9

(2015) Samuel H. Sternberg et al.   MOLECULAR CELL

Measuring and Reducing Off-Target Activities of Programmable Nucleases Including CRISPR-Cas9

(2015) Taeyoung Koo et al.   MOLECULES AND CELLS

CRISPR, the disruptor

(2015) Heidi Ledford   NATURE

Efficient Mitochondrial Genome Editing by CRISPR/Cas9

(2015) Areum Jo et al.   Biomed Research International

Generation of SNCA Cell Models Using Zinc Finger Nuclease (ZFN) Technology for Efficient High-Throughput Drug Screening

(2015) Warunee Dansithong et al.   PLoS One

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer

(2014) Xiaoqing Zhou et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

CRISPR-Cas Systems: Prokaryotes Upgrade to Adaptive Immunity

(2014) Rodolphe Barrangou et al.   MOLECULAR CELL

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

Unravelling the structural and mechanistic basis of CRISPR–Cas systems

(2014) John van der Oost et al.   NATURE REVIEWS MICROBIOLOGY

Gene Therapy for the Nervous System: Challenges and New Strategies

(2014) Casey A. Maguire et al.   Neurotherapeutics

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

The current and projected economic burden of Parkinson's disease in the United States

(2013) Stacey L. Kowal et al.   MOVEMENT DISORDERS

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

(2013) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction

(2013) Laurie H. Sanders et al.   NEUROBIOLOGY OF DISEASE

Premotor Parkinson's disease: Concepts and definitions

(2012) Andrew Siderowf et al.   MOVEMENT DISORDERS

RNA-mediated programmable DNA cleavage

(2012) Rodolphe Barrangou   NATURE BIOTECHNOLOGY

Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

(2012) G. Gasiunas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Effect of divalent metals on the neuronal proteasomal system, prion protein ubiquitination and aggregation

(2012) A.G. Kanthasamy et al.   TOXICOLOGY LETTERS

Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

(2011) Frank Soldner et al.   CELL

Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's disease

(2011) Cameron H. Good et al.   FASEB JOURNAL

Differential regional expression patterns of alpha-synuclein, TNF-alpha, and IL-1beta; and variable status of dopaminergic neurotoxicity in mouse brain after Paraquat treatment

(2011) Soham Mitra et al.   Journal of Neuroinflammation

CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III

(2011) Elitza Deltcheva et al.   NATURE

Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription

(2011) Feng Zhang et al.   NATURE BIOTECHNOLOGY

The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli

(2011) Rimantas Sapranauskas et al.   NUCLEIC ACIDS RESEARCH

Chromosome integrity at a double-strand break requires exonuclease 1 and MRX

(2010) Wataru Nakai et al.   DNA REPAIR

Mitochondrial dysfunction: A potential link between neuroinflammation and neurodegeneration?

(2010) Maarten E. Witte et al.   MITOCHONDRION

The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

(2010) Josiane E. Garneau et al.   NATURE

Manganese exposure induces microglia activation and dystrophy in the substantia nigra of non-human primates

(2010) Tatyana Verina et al.   NEUROTOXICOLOGY

Prokineticin-1 evokes secretory and contractile activity in rat small intestine

(2009) p. r. wade et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The MitoPark Mouse – An animal model of Parkinson's disease with impaired respiratory chain function in dopamine neurons

(2009) Mats I. Ekstrand et al.   PARKINSONISM & RELATED DISORDERS

Dopamine Gene Therapy for Parkinson's Disease in a Nonhuman Primate Without Associated Dyskinesia

(2009) B. Jarraya et al.   Science Translational Medicine

Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes

(2008) S. J. J. Brouns et al.   SCIENCE

CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA

(2008) Luciano A. Marraffini et al.   SCIENCE