Cathepsin L activated by mutant p53 and Egr-1 promotes ionizing radiation-induced EMT in human NSCLC

FBW7 loss promotes epithelial-to-mesenchymal transition in non-small cell lung cancer through the stabilization of Snail protein

(2018) Yong Zhang et al.   CANCER LETTERS

Fibroblast growth factor 2 induces proliferation and fibrosis via SNAI1-mediated activation of CDK2 and ZEB1 in corneal endothelium

(2018) Jeong Goo Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation

(2017) Su Yeon Lee et al.   Molecular Cancer

AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination

(2017) Michael C. Haffner et al.   Nature Communications

Egr-1 regulates irradiation-induced autophagy through Atg4B to promote radioresistance in hepatocellular carcinoma cells

(2017) W-x Peng et al.   Oncogenesis

Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells

(2016) Tripti Tamhane et al.   BIOCHIMIE

Knockdown of Cathepsin L promotes radiosensitivity of glioma stem cells both in vivo and in vitro

(2016) Wenjuan Wang et al.   CANCER LETTERS

Cystatin C as a p53-inducible apoptotic mediator that regulates cathepsin L activity

(2016) Jinichi Mori et al.   CANCER SCIENCE

Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model

(2016) Dhivya R. Sudhan et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer cell motility is affected through 3D cell culturing and SCF/c-Kit pathway but not by X-irradiation

(2016) Fabian Eberle et al.   RADIOTHERAPY AND ONCOLOGY

Synthesis and Preclinical Evaluation of a Highly Improved Anticancer Prodrug Activated by Histone Deacetylases and Cathepsin L

(2016) Nobuhide Ueki et al.   Theranostics

Role of EMT in Metastasis and Therapy Resistance

(2016) Bethany Smith et al.   Journal of Clinical Medicine

Cathepsin L suppression increases the radiosensitivity of human glioma U251 cells via G2/M cell cycle arrest and DNA damage

(2015) Qing-qing Zhang et al.   ACTA PHARMACOLOGICA SINICA

Early Growth Response Protein-1 Involves in Transforming Growth factor-β1 Induced Epithelial-Mesenchymal Transition and Inhibits Migration of Non-Small-Cell Lung Cancer Cells

(2015) Li-Na Shan et al.   Asian Pacific Journal of Cancer Prevention

DNA damage-induced ephrin-B2 reverse signaling promotes chemoresistance and drives EMT in colorectal carcinoma harboring mutant p53

(2015) S K Alam et al.   CELL DEATH AND DIFFERENTIATION

Azadirachtin-induced apoptosis involves lysosomal membrane permeabilization and cathepsin L release in Spodoptera frugiperda Sf9 cells

(2015) Zheng Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Silencing Egr1 Attenuates Radiation-Induced Apoptosis in Normal Tissues while Killing Cancer Cells and Delaying Tumor Growth

(2015) D. Y. Zhao et al.   MOLECULAR CANCER THERAPEUTICS

Downregulation of cathepsin L suppresses cancer invasion and migration by inhibiting transforming growth factor-β-mediated epithelial-mesenchymal transition

(2015) QINGQING ZHANG et al.   ONCOLOGY REPORTS

Γ-Ionizing radiation-induced activation of the EGFR–p38/ERK–STAT3/CREB-1–EMT pathway promotes the migration/invasion of non-small cell lung cancer cells and is inhibited by podophyllotoxin acetate

(2015) Jeong Hyun Cho et al.   TUMOR BIOLOGY

TP53 Mutations and Lung Cancer: Not All Mutations Are Created Equal

(2014) R. Govindan et al.   CLINICAL CANCER RESEARCH

Targeting Chemokine Receptor CXCR4 for Treatment of HIV-1 Infection, Tumor Progression, and Metastasis

(2014) Won-Tak Choi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Overexpression of cysteine cathepsin L is a marker of invasion and metastasis in ovarian cancer

(2014) WEI ZHANG et al.   ONCOLOGY REPORTS

NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro

(2013) Wen-juan Wang et al.   ACTA PHARMACOLOGICA SINICA

Genetics and biomarkers in personalisation of lung cancer treatment

(2013) Rafael Rosell et al.   LANCET

Consistency Test of the Cell Cycle: Roles for p53 and EGR1

(2012) Y. Zwang et al.   CANCER RESEARCH

Mutant p53 gain-of-function induces epithelial–mesenchymal transition through modulation of the miR-130b–ZEB1 axis

(2012) P Dong et al.   ONCOGENE

Localization of nuclear cathepsin L and its association with disease progression and poor outcome in colorectal cancer

(2009) Shane Sullivan et al.   INTERNATIONAL JOURNAL OF CANCER

Cathepsin L, target in cancer treatment?

(2009) Jacqueline M. Lankelma et al.   LIFE SCIENCES