Bazedoxifene as a novel GP130 inhibitor for Colon Cancer therapy

The length of the interleukin-11 receptor stalk determines its capacity for classic signaling

(2018) Juliane Lokau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-11 contribution to tumorigenesis in an NRF2 addiction cancer model

(2017) H Kitamura et al.   ONCOGENE

The evolving role of oral hormonal therapies and review of conjugated estrogens/bazedoxifene for the management of menopausal symptoms

(2017) Sharon J. Parish et al.   POSTGRADUATE MEDICINE

Therapeutically blocking interleukin-11 receptor-α enhances doxorubicin cytotoxicity in high grade type I endometrioid tumours

(2017) Amy Winship et al.   Oncotarget

WBSCR22 confers oxaliplatin resistance in human colorectal cancer

(2017) Dongmei Yan et al.   Scientific Reports

Interleukin-11 Receptor Is a Candidate Target for Ligand-Directed Therapy in Lung Cancer

(2016) Marina Cardó-Vila et al.   AMERICAN JOURNAL OF PATHOLOGY

The role of IL-11 in immunity and cancer

(2016) Dixon H. Xu et al.   CANCER LETTERS

Transcriptional activation of FN1 and IL11 by HMGA2 promotes the malignant behavior of colorectal cancer

(2016) Jingjing Wu et al.   CARCINOGENESIS

Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy

(2016) X. Wu et al.   MOLECULAR CANCER THERAPEUTICS

Changes in cellular mechanical properties during onset or progression of colorectal cancer

(2016) Gabriele Ciasca et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Development of Small Molecules Targeting the Wnt Signaling Pathway in Cancer Stem Cells for the Treatment of Colorectal Cancer

(2015) Lele Song et al.   Clinical Colorectal Cancer

STAT3-Activating Cytokines: A Therapeutic Opportunity for Inflammatory Bowel Disease?

(2015) Paul M. Nguyen et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Enhancement of oxaliplatin-induced cell apoptosis and tumor suppression by 3-methyladenine in colon cancer

(2015) SHISHENG TAN et al.   Oncology Letters

Targeting IL-11 signaling in colon cancer

(2015) Matthias Ernst et al.   Oncotarget

Molecular Pathways: IL11 as a Tumor-Promoting Cytokine--Translational Implications for Cancers

(2014) M. Ernst et al.   CLINICAL CANCER RESEARCH

Impact of microRNAs in Resistance to Chemotherapy and Novel Targeted Agents in Non-Small Cell Lung Cancer

(2014) Christian Rolfo et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Drug Design Targeting Protein–Protein Interactions (PPIs) Using Multiple Ligand Simultaneous Docking (MLSD) and Drug Repositioning: Discovery of Raloxifene and Bazedoxifene as Novel Inhibitors of IL-6/GP130 Interface

(2014) Huameng Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Epithelial gp130/Stat3 functions: An intestinal signaling node in health and disease

(2014) Matthias Ernst et al.   SEMINARS IN IMMUNOLOGY

Friend or foe: the role of microRNA in chemotherapy resistance

(2013) Haoran Li et al.   ACTA PHARMACOLOGICA SINICA

Interleukin-11 Is the Dominant IL-6 Family Cytokine during Gastrointestinal Tumorigenesis and Can Be Targeted Therapeutically

(2013) Tracy L. Putoczki et al.   CANCER CELL

Bone metastasis from breast cancer involves elevated IL-11 expression and the gp130/STAT3 pathway

(2013) Li Ren et al.   MEDICAL ONCOLOGY

Dietary Iron Enhances Colonic Inflammation and IL-6/IL-11-Stat3 Signaling Promoting Colonic Tumor Development in Mice

(2013) Anita C. G. Chua et al.   PLoS One

Plasticity and cross-talk of Interleukin 6-type cytokines

(2012) Christoph Garbers et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Interleukin 11 regulates endometrial cancer cell adhesion and migration via STAT3

(2012) VIRGINIA LAY et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage

(2011) S. I. Grivennikov et al.   ANNALS OF THE RHEUMATIC DISEASES

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Cytokine signalling via gp130 in gastric cancer

(2009) M. Howlett et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk Factors

(2009) Fatima Haggar et al.   Clinics in Colon and Rectal Surgery