Emerging role of testosterone in pancreatic β cell function and insulin secretion

Androgen signaling expands β-cell mass in male rats and β-cell androgen receptor is degraded under high-glucose conditions

(2018) Naoki Harada et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Elevated androgen levels induce hyperinsulinemia through increase in Ins1 transcription in pancreatic beta cells in female rats†

(2018) Jay S Mishra et al.   BIOLOGY OF REPRODUCTION

Role of androgens in energy metabolism affecting on body composition, metabolic syndrome, type 2 diabetes, cardiovascular disease, and longevity: lessons from a meta-analysis and rodent studies

(2018) Naoki Harada   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

The impact of androgen actions in neurons on metabolic health and disease

(2018) Jamie J. Morford et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

MECHANISMS IN ENDOCRINOLOGY: The sexually dimorphic role of androgens in human metabolic disease

(2017) Lina Schiffer et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Development and Risk Factors of Type 2 Diabetes in a Nationwide Population of Women With Polycystic Ovary Syndrome

(2017) Katrine Hass Rubin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Androgen receptor-deficient islet β-cells exhibit alteration in genetic markers of insulin secretion and inflammation. A transcriptome analysis in the male mouse

(2017) Weiwei Xu et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

High T Gives β Cells a Boost

(2016) Matthew Wortham et al.   Cell Metabolism

Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male

(2016) Guadalupe Navarro et al.   Cell Metabolism

HKDC1 Is a Novel Hexokinase Involved in Whole-Body Glucose Use

(2016) Anton E. Ludvik et al.   ENDOCRINOLOGY

Interferon-induced guanylate-binding proteins in inflammasome activation and host defense

(2016) Bae-Hoon Kim et al.   NATURE IMMUNOLOGY

Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling

(2016) Verena A. Bachmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Sex Steroids in β Cell Function, Growth, and Survival

(2016) Franck Mauvais-Jarvis   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Polycystic ovary syndrome

(2016) Ricardo Azziz et al.   Nature Reviews Disease Primers

Pancreatic β-cell dysfunction in polycystic ovary syndrome: role of hyperglycemia-induced nuclear factor-κB activation and systemic inflammation

(2015) Steven K. Malin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The role of androgens in metabolism, obesity, and diabetes in males and females

(2015) Guadalupe Navarro et al.   Obesity

The Role of β Cell Glucagon-like Peptide-1 Signaling in Glucose Regulation and Response to Diabetes Drugs

(2014) Eric P. Smith et al.   Cell Metabolism

Effects of testosterone treatment on glucose metabolism and symptoms in men with type 2 diabetes and the metabolic syndrome: a systematic review and meta-analysis of randomized controlled clinical trials

(2014) Mathis Grossmann et al.   CLINICAL ENDOCRINOLOGY

Increased serum CXCL1 and CXCL5 are linked to obesity, hyperglycemia, and impaired islet function

(2014) Craig S Nunemaker et al.   JOURNAL OF ENDOCRINOLOGY

Induction mechanism of lipocalin-2 expression by co-stimulation with interleukin-1β and interferon-γ in RINm5F beta-cells

(2013) Seo-Yoon Chang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gpr126 Functions in Schwann Cells to Control Differentiation and Myelination via G-Protein Activation

(2013) A. Mogha et al.   JOURNAL OF NEUROSCIENCE

Testosterone Replacement Therapy Improves Metabolic Parameters in Hypogonadal Men with Type 2 Diabetes but Not in Men with Coexisting Depression: The BLAST Study

(2013) Geoffrey Hackett et al.   Journal of Sexual Medicine

A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets

(2012) P. Marchetti et al.   DIABETOLOGIA

Activity-Dependent IGF-1 Exocytosis Is Controlled by the Ca2+-Sensor Synaptotagmin-10

(2011) Peng Cao et al.   CELL

Testosterone Replacement in Hypogonadal Men With Type 2 Diabetes and/or Metabolic Syndrome (the TIMES2 Study)

(2011) T. H. Jones et al.   DIABETES CARE

Stromal cell-derived factor-1 (SDF-1)/chemokine (C-X-C motif) receptor 4 (CXCR4) axis activation induces intra-islet glucagon-like peptide-1 (GLP-1) production and enhances beta cell survival

(2011) Z. Liu et al.   DIABETOLOGIA

GPR26-deficient mice display increased anxiety- and depression-like behaviors accompanied by reduced phosphorylated cyclic AMP responsive element-binding protein level in central amygdala

(2011) L.-L. Zhang et al.   NEUROSCIENCE

Metabolic sequelae associated with androgen deprivation therapy for prostate cancer

(2011) Jason E Faris et al.   Current Opinion in Endocrinology Diabetes and Obesity

Extranuclear estrogen receptor-  stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis

(2010) W. P. S. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CXCL10 Impairs β Cell Function and Viability in Diabetes through TLR4 Signaling

(2009) Fabienne T. Schulthess et al.   Cell Metabolism

Nonsteroidal Selective Androgen Receptor Modulators (SARMs): Dissociating the Anabolic and Androgenic Activities of the Androgen Receptor for Therapeutic Benefit

(2009) Michael L. Mohler et al.   JOURNAL OF MEDICINAL CHEMISTRY

Diabetes and Cardiovascular Disease During Androgen Deprivation Therapy: Observational Study of Veterans With Prostate Cancer

(2009) N. L. Keating et al.   JNCI-Journal of the National Cancer Institute

Testosterone deficiency, insulin resistance and the metabolic syndrome

(2009) Michael Zitzmann   Nature Reviews Endocrinology

Interleukin 22 Receptor 1 Expression in Pancreas Islets

(2009) Makoto Shioya et al.   PANCREAS

A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic β-cells

(2008) Catherine Arden et al.   BIOCHEMICAL JOURNAL

Pathophysiological roles of osteoprotegerin (OPG)

(2008) Penny Reid et al.   EUROPEAN JOURNAL OF CELL BIOLOGY