Review
Biochemistry & Molecular Biology
Takeshi Iwasa, Hiroki Noguchi, Risa Tanano, Erika Yamanaka, Asuka Takeda, Kou Tamura, Hidenori Aoki, Tatsuro Sugimoto, Hikari Sasada, Takaaki Maeda, Saki Minato, Shota Yamamoto, Hiroaki Inui, Tomohiro Kagawa, Atsuko Yoshida, Ayuka Mineda, Mari Nii, Riyo Kinouchi, Kanako Yoshida, Yuri Yamamoto, Takashi Kaji
Summary: Recent studies have revealed the effects of androgens on metabolic and body weight regulation systems in females and elucidated the underlying mechanisms. Excess androgens can negatively impact metabolic functioning, appetite, and body weight regulation, increasing the risk of metabolic disorders. These effects are caused by changes in hypothalamic appetite-regulatory factors, decreased energy expenditure, skeletal muscle insulin resistance, and beta-cell dysfunction. Interestingly, these adverse effects of androgens are not observed in ovariectomized animals and post-menopausal women, suggesting a potential dependence on the estrogen milieu. The findings may provide novel strategies for sex- and age-specific treatment of metabolic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Elizabeth A. McCarthy, Daniel Dischino, Caroline Maguire, Silvia Leon, Rajae Talbi, Eugene Cheung, Claudio D. Schteingart, Pierre J. M. Riviere, Susan D. Reed, Robert A. Steiner, Victor M. Navarro
Summary: The activation of kappa receptors to inhibit kisspeptin neuronal activity shows potential as a novel therapeutic approach for treating VMS and PCOS.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Anne-Laure Barbotin, Nour El Houda Mimouni, Gregory Kuchcinski, Renaud Lopes, Romain Viard, Sowmyalakshmi Rasika, Daniele Mazur, Mauro S. B. Silva, Virginie Simon, Angele Boursier, Jean-Pierre Pruvo, Qiang Yu, Michael Candlish, Ulrich Boehm, Federica Dal Bello, Claudio Medana, Pascal Pigny, Didier Dewailly, Vincent Prevot, Sophie Catteau-Jonard, Paolo Giacobinia
Summary: Polycystic ovary syndrome (PCOS) is a common reproductive-endocrine disorder. This study investigates the brain structure and function in PCOS patients and reveals the role of AMH in regulating fertility and neuroendocrine dysfunction.
Article
Endocrinology & Metabolism
Hiroe Okada, Haruhiko Kanasaki, Tuvshintugs Tumurbaatar, Zolzaya Tumurgan, Aki Oride, Satoru Kyo
Summary: This study found that supplementation with androgens affects the characteristics of KNDy neurons, increasing kisspeptin and NKB levels and decreasing DynA levels. These changes may lead to dysfunction of the hypothalamic-pituitary-gonadal axis.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Marilena Marraudino, Beatriz Carrillo, Brigitta Bonaldo, Ricardo Llorente, Elia Campioli, Iciar Garate, Helena Pinos, Luis Miguel Garcia-Segura, Paloma Collado, Daniela Grassi
Summary: The study evaluated the distribution of GPER in the rat hypothalamus, showing that GPER immunoreactivity is expressed in neurons, astrocytes, and oligodendrocytes, with differences observed in different sexes, regions, and stages of the estrous cycle in females.
NEUROENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
D. J. Innes, N. J. Hudson, S. T. Anderson, D. P. Poppi, S. P. Quigley
Summary: A reduction in voluntary feed intake is observed in ruminants consuming nutrient-deficient diets, such as those with a low CP or P content, and has been attributed to active metabolic regulation, rather than a physical constraint. The hypothalamus is the key integrator of feed intake regulation in mammals. The objectives of this experiment were to establish a model of metabolic feed intake regulation in ruminants consuming diets of variable CP and P content, and determine key biochemical pathways and influential points of regulation within the hypothalamus.
Article
Medicine, General & Internal
Gulnar Mammadova, Ceren Ozkul, Selen Yilmaz Isikhan, Aylin Acikgoz, Bulent O. Yildiz
Summary: The gut microbiome of lean PCOS patients with full phenotype showed compositional alterations with similar bacterial richness and diversity compared to controls. Hyperandrogenism is associated with dysbiosis in the gut microbiota of PCOS patients.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Xi Luo, Wang-Yu Cai, Hong-Li Ma, Jing Cong, Hui Chang, Jing-Shu Gao, Wen-Juan Shen, Yu Wang, Xin-Ming Yang, Xiao-Ke Wu
Summary: The study found that there is a negative association between serum magnesium and insulin resistance index and testosterone level in women with PCOS. Lower levels of serum magnesium are correlated with worsened insulin resistance and higher testosterone levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Morgan R. R. Firestein, Russell D. D. Romeo, Hailey Winstead, Danielle A. A. Goldman, William A. A. Grobman, David M. M. Haas, Samuel Parry, Uma M. M. Reddy, Robert M. M. Silver, Ronald J. J. Wapner, Frances A. A. Champagne
Summary: Prenatal exposure to testosterone may be related to autism spectrum disorder. Hypertensive disorders of pregnancy and polycystic ovary syndrome can lead to increased levels of testosterone and increased risk of ASD. This study found that increased maternal testosterone mediates the relationship between these hyperandrogenic disorders and child communication and social skills.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biology
Wenyu Ding, Changjiang Zhang, Baisong Wang, Xin Zhou, Le Sun, Suijuan Zhong, Jing Liu, Junjing Zhang, Xiaoqun Wang, Qian Wu
Summary: The study reveals the crucial roles of the centrosomal protein Cenpj in neurogenesis, cerebral cortex development, and body weight regulation. Deletion of Cenpj leads to obesity in mice and affects hypothalamic cell proliferation, neuron number, and function, providing insights into the pathological mechanisms of related diseases.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Datu Agasi Mohd Kamal, Siti Fatimah Ibrahim, Azizah Ugusman, Mohd Helmy Mokhtar
Summary: This study found aberrant expression of sex steroid receptors in polycystic ovary syndrome and demonstrated that Kelulut honey treatment can normalize the expression of these receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jing Luo, Hong Ye, Lijuan Hao, Yixuan Sun, Ruohan Li, Yanxi Li, Zhu Yang
Summary: The study identified the presence of AR alternative splicing variants AR-SVs in PCOS patients' GCs, leading to reduced AR function. miRNA-183 and miRNA-124 were found to regulate the expression of SRSF2 and SRSF3, influencing AR function and androgen accumulation in the ovary.
Article
Endocrinology & Metabolism
Youran Li, Yanhong Zhai, Lin Li, Yifan Lu, Shaofei Su, Ying Liu, Zhengwen Xu, Mingwei Xin, Qiaoli Zhang, Zheng Cao
Summary: This study highlights the associations between serum androgen levels and ovarian reserve markers in patients with polycystic ovary syndrome (PCOS) and non-PCOS women. The results show a positive correlation between serum androgen levels and anti-mullerian hormone (AMH) levels, with testosterone (T) showing a stronger correlation with AMH in the PCOS group.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Francesco Di Pierro, Ruqqia Sultana, Amna Zia Eusaph, Saida Abrar, Mahroo Bugti, Fauzia Afridi, Umer Farooq, Somia Iqtadar, Fareeha Ghauri, Syeda Makhduma, Shazia Nourin, Ayesha Kanwal, Aasiya Bano, Ali Akbar Bugti, Shah Mureed, Ayesha Ghazal, Romana Irshad, Martino Recchia, Alexander Bertuccioli, Pietro Putignano, Antonella Riva, Luigina Guasti, Nicola Zerbinati, Amjad Khan
Summary: A multi-centric, randomized, controlled and prospective study found that supplementation with Berberine Phytosome (BP), a more easily absorbed form of berberine, can improve menstrual and ovary abnormalities in women with polycystic ovary syndrome (PCOS), with good tolerability and safety.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Bushra Hassan Marouf, Dana Omer Ismaeel, Ali Hussein Hassan, Othman Jalal Ali
Summary: Silibinin is effective in restoring estrous regularities and alleviating hormonal and histomorphological abnormalities of the ovarian and uterine tissues, which may be attributed to its anti-androgenic, anti-inflammatory, and antioxidant properties.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)