Review
Cell Biology
Sydney Diep, Mahita Maddukuri, Stephanie Yamauchi, Ganamee Geshow, Nikki A. Delk
Summary: IL-1 inflammatory signaling plays a crucial role in breast cancer progression and therapeutic resistance by promoting cell proliferation, stem cell expansion, angiogenesis, metastasis, regulating intracellular signaling, and allowing tumor cells to evade therapy.
Article
Chemistry, Medicinal
Yeo Dae Yoon, Myeong Youl Lee, Byeong Jo Choi, Chang Woo Lee, Hyunju Lee, Joo-Hee Kwon, Jeong-Wook Yang, Jong Soon Kang
Summary: This study found that Terrein has a protective effect against LPS-induced endotoxemia by reducing the production of inflammatory cytokines. The anti-inflammatory effect of Terrein might be mediated, at least in part, by blocking the activation of NF-kappa B, JNK, and p38 MAPK signaling pathways.
Article
Multidisciplinary Sciences
Sijie (Shirley) Yang, Svetlana Simtchouk, Julien Gibon, Andis Klegeris
Summary: The phagocytic activity of glial cells is crucial for normal brain function and dysregulation can contribute to neurodegenerative diseases. This study investigated the modulation of phagocytic activity in astrocytic cells by CNS inflammatory mediators and bacterial endotoxin lipopolysaccharide (LPS), and identified four potential regulators and toll-like receptor 4 involvement. Further investigation into the molecular mechanisms could lead to novel therapeutic targets for CNS pathologies.
Editorial Material
Microbiology
Robert Z. Zhang, Melissa Kane
Summary: HIV-1 both inhibits and activates the NF-kappa B pathway, which is important for the viral life cycle. The viral protein U has contrasting effects on beta-TrCP1 and beta-TrCP2, leading to dysregulation of the NF-kappa B pathways. These findings enhance our understanding of how the NF-kappa B pathway functions during viral infection.
Article
Multidisciplinary Sciences
Seoyun Yum, Minghao Li, Yan Fang, Zhijian J. Chen
Summary: This study shows that STING can function independently of type I interferons and autophagy, and that TBK1 recruitment to STING is essential for antiviral and antitumor immunity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Junya Masumoto, Wei Zhou, Shinnosuke Morikawa, Sho Hosokawa, Haruka Taguchi, Toshihiro Yamamoto, Mie Kurata, Naoe Kaneko
Summary: This review explores the molecular mechanisms underlying several autoinflammatory diseases, which are typically associated with dysregulation of pattern recognition receptors and can lead to inflammasomopathies, relopathies, interferonopathies, and proteasome-associated autoinflammatory syndromes.
INFLAMMATION AND REGENERATION
(2021)
Article
Multidisciplinary Sciences
Vishwas Mishra, Anna Crespo-Puig, Callum McCarthy, Tereza Masonou, Izabela Glegola-Madejska, Alice Dejoux, Gabriella Dow, Matthew J. G. Eldridge, Luciano H. Marinelli, Meihan Meng, Shijie Wang, Daniel J. Bennison, Rebecca Morrison, Avinash R. Shenoy
Summary: The study reveals that UBE2L3 is involved in the degradation of pro-IL-1 beta and its dysregulation leads to excessive production of mature IL-1 beta, causing inflammation and disease. The specific E3 ligases TRIP12 and AREL1 are identified as the partners of UBE2L3 in promoting the ubiquitination of pro-IL-1 beta and its subsequent proteasomal breakdown.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Supattra Charoenwutthikun, Kasem Chanjitwiriya, Sittiruk Roytrakul, Duangkamol Kunthalert
Summary: This study explored the anti-gout potential of the Rice14 (R14) peptide derived from wild rice leaves. The results showed that the R14 peptide significantly inhibited the secretion of IL-1 beta in MSU crystals-induced macrophages, and the effects were dose-related. Additionally, the R14 peptide suppressed NF-kappa B and NLRP3 activation to inhibit IL-1 beta production in MSU crystals-induced inflammation.
Article
Clinical Neurology
Jing Lu, Kangyu Jin, Jianping Jiao, Ripeng Liu, Tingting Mou, Bing Chen, Zhihan Zhang, Chaonan Jiang, Haoyang Zhao, Zheng Wang, Rui Zhou, Manli Huang
Summary: This study found that the increased activity of the YY1-NF-kappa B-IL-1 beta inflammatory pathway plays an important role in mood and cognitive impairment in patients with depression. This inflammatory pathway is associated with changes in glucose metabolism, and these changes can be reversed by treatment with vortioxetine.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Integrative & Complementary Medicine
Guangwen Xie, Ting Wang, Huirong Zhou, Liang Yi, Jie He, Jun Zhang, Ming Li, Youzhe Yang
Summary: The study investigated the therapeutic effects and mechanisms of HSYA+SH in the treatment of cartilage tissue in rabbits with KOA. The combination treatment reduced apoptosis, decreased inflammatory factors, and protected against KOA-induced cartilage tissue injury, possibly through regulating the Notch1 signaling pathway.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2023)
Article
Cell Biology
Xuan Li, Wanlu Xie, Qiong Pan, Xiaoxun Zhang, Liangjun Zhang, Nan Zhao, Qiaoling Xie, Jingjing Ding, Jin Chai
Summary: This study found that both SEMA7A mutation and overexpression can activate the NF-κB p50/p65 pathway through integrin beta 1 and play a crucial role in inflammatory responses.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Yumiko Tanaka, Ayaka Nakao, Yasunobu Miyake, Yukina Higashi, Riho Tanigaki, Takao Kataoka
Summary: The T-box transcription factor Eomes promotes IFN-gamma expression, which was not significantly reduced by NF-kappa B inhibitors TPCA-1 and IKK-16 in mouse lymphoma cells and primary effector T cells expressing Eomes. NF-kappa B is dispensable for IFN-gamma expression induced by PMA and calcium ionophores, but plays a role in IL-2 expression in Eomes-transfected EL4 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Elizabeta Georgieva, Stefan L. Leber, Cora Wex, Christoph Garbers
Summary: The study reveals that perturbation of the actin cytoskeleton is not sufficient to induce NF-kappa B activation and IL-6 secretion, but it reduces IL-6-induced activation of STAT3 in Hep3B cells. Additionally, IL-6 receptor proteolysis by ADAM10 is not dependent on the integrity of the actin cytoskeleton.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Lipeng Tang, Tong Li, Bowen Zhang, Zihao Zhang, Xiaoyi Sun, Ying Zhu, Bing Feng, Zuqing Su, Laijun Yang, Hongxia Li, Huazhen Liu, Yuchao Chen, Zhenhua Dai, Xirun Zheng, Mingxian Li, Chutian Li, Jie Zhao, Xinmin Qiu, Shuyan Ye, Han Liu, Guangjuan Zheng, Ben Li, Chuanjian Lu
Summary: Punicalagin (PUN) shows therapeutic potential for psoriasis by inhibiting inflammatory response and cell signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Monica Zuzarte, Catia Sousa, Carlos Cavaleiro, Maria Teresa Cruz, Ligia Salgueiro
Summary: Portuguese lavenders remain undervalued in global markets due to the lack of high-quality end-products and scarcity of scientific-based studies validating their bioactive potential. This study assessed the anti-inflammatory potential of L. luisieri and L. pedunculata, two prevalent species in Portugal, and correlated it with their chemical variability. The results demonstrated that L. luisieri essential oil with low quantities of necrodane derivatives was the most effective at inhibiting inflammation.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)