Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation
出版年份 2019 全文链接
标题
Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation
作者
关键词
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出版物
JOURNAL OF CLINICAL INVESTIGATION
Volume -, Issue -, Pages -
出版商
American Society for Clinical Investigation
发表日期
2019-02-27
DOI
10.1172/jci124590
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Isolation and functional assessment of mouse skeletal stem cell lineage
- (2018) Gunsagar S Gulati et al. Nature Protocols
- Discovery of a periosteal stem cell mediating intramembranous bone formation
- (2018) Shawon Debnath et al. NATURE
- Targeting VEGF pathway to normalize the vasculature: an emerging insight in cancer therapy
- (2018) Jingbiao Wu et al. OncoTargets and Therapy
- Osteogenic Sarcoma: A 21st Century Review
- (2016) STEPHEN OSASAN et al. ANTICANCER RESEARCH
- WWOX and p53 Dysregulation Synergize to Drive the Development of Osteosarcoma
- (2016) S. Del Mare et al. CANCER RESEARCH
- mTOR Inhibition Mitigates Enhanced mRNA Translation Associated with the Metastatic Phenotype of Osteosarcoma Cells In Vivo
- (2016) J. J. Morrow et al. CLINICAL CANCER RESEARCH
- Inactivation of Regulatory-associated Protein of mTOR (Raptor)/Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Osteoclasts Increases Bone Mass by Inhibiting Osteoclast Differentiation in Mice
- (2016) Qinggang Dai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NOTCH signaling in skeletal progenitors is critical for fracture repair
- (2016) Cuicui Wang et al. JOURNAL OF CLINICAL INVESTIGATION
- LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
- (2016) Filippos Kottakis et al. NATURE
- Osteosarcoma: Cells-of-Origin, Cancer Stem Cells, and Targeted Therapies
- (2016) Ander Abarrategi et al. Stem Cells International
- Targeting LKB1 in cancer – exposing and exploiting vulnerabilities
- (2015) M Momcilovic et al. BRITISH JOURNAL OF CANCER
- Identification and Specification of the Mouse Skeletal Stem Cell
- (2015) Charles K.F. Chan et al. CELL
- Sorafenib and everolimus for patients with unresectable high-grade osteosarcoma progressing after standard treatment: a non-randomised phase 2 clinical trial
- (2015) Giovanni Grignani et al. LANCET ONCOLOGY
- A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis
- (2015) Branden S Moriarity et al. NATURE GENETICS
- Cells of origin in osteosarcoma: Mesenchymal stem cells or osteoblast committed cells?
- (2014) Anthony J. Mutsaers et al. BONE
- Notch Activation as a Driver of Osteogenic Sarcoma
- (2014) Jianning Tao et al. CANCER CELL
- Novel mutations and role of the LKB1 gene as a tumor suppressor in renal cell carcinoma
- (2014) Zübeyde Yalniz et al. TUMOR BIOLOGY
- Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA
- (2013) Anthony J. Mutsaers et al. BONE
- The Combination of Sorafenib and Everolimus Abrogates mTORC1 and mTORC2 Upregulation in Osteosarcoma Preclinical Models
- (2013) Y. Pignochino et al. CLINICAL CANCER RESEARCH
- Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling
- (2013) Wentian Yang et al. NATURE
- Lkb1/Stk11 regulation of mTOR signaling controls the transition of chondrocyte fates and suppresses skeletal tumor formation
- (2013) L. P. Lai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nouvelle classification de l’OMS des tumeurs des tissus mous et des os
- (2012) Jean-Michel Coindre ANNALES DE PATHOLOGIE
- LKB1/STK11 Inactivation Leads to Expansion of a Prometastatic Tumor Subpopulation in Melanoma
- (2012) Wenjin Liu et al. CANCER CELL
- Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee
- (2012) David W Dempster et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Genetic mouse models for bone studies—Strengths and limitations
- (2011) Florent Elefteriou et al. BONE
- Phase II Study of the Mammalian Target of Rapamycin Inhibitor Ridaforolimus in Patients With Advanced Bone and Soft Tissue Sarcomas
- (2011) Sant P. Chawla et al. JOURNAL OF CLINICAL ONCOLOGY
- Rb regulates fate choice and lineage commitment in vivo
- (2010) Eliezer Calo et al. NATURE
- LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
- (2009) R. J. Shaw Acta Physiologica
- Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice
- (2009) P. P. Lin et al. CARCINOGENESIS
- Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice
- (2009) Maya Kansara et al. JOURNAL OF CLINICAL INVESTIGATION
- A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
- (2009) Linda Madisen et al. NATURE NEUROSCIENCE
- Osteogenic tumours in Lkb1-deficient mice
- (2008) James Robinson et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease
- (2008) C. R. Walkley et al. GENES & DEVELOPMENT
- Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage
- (2008) S. D. Berman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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