Inhibiting Wee1 and ATR kinases produces tumor-selective synthetic lethality and suppresses metastasis

Targeting the replication stress response in cancer

(2018) Josep V. Forment et al.   PHARMACOLOGY & THERAPEUTICS

Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place

(2018) Panagiotis Kotsantis et al.   Cancer Discovery

Combined Inhibition of ATR and WEE1 as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer

(2018) Juan Jin et al.   NEOPLASIA

An intrinsic S/G2 checkpoint enforced by ATR

(2018) Joshua C. Saldivar et al.   SCIENCE

Directing the use of DDR kinase inhibitors in cancer treatment

(2017) Inger Brandsma et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

DNA Damage in Stem Cells

(2017) Ilio Vitale et al.   MOLECULAR CELL

Coupling of Homologous Recombination and the Checkpoint by ATR

(2017) Rémi Buisson et al.   MOLECULAR CELL

Orthotopic patient-derived xenografts of paediatric solid tumours

(2017) Elizabeth Stewart et al.   NATURE

Synthetic lethality and cancer

(2017) Nigel J. O'Neil et al.   NATURE REVIEWS GENETICS

A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation

(2017) Lilian Kabeche et al.   SCIENCE

Prolonged mitotic arrest induced by Wee1 inhibition sensitizes breast cancer cells to paclitaxel

(2017) Cody W. Lewis et al.   Oncotarget

Potential biomarkers of DNA replication stress in cancer

(2017) Liqun Ren et al.   Oncotarget

ATM-deficiency increases genomic instability and metastatic potential in a mouse model of pancreatic cancer

(2017) Yiannis Drosos et al.   Scientific Reports

TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres

(2016) Tatsuya Kibe et al.   MOLECULAR CELL

Targeting WEE1 Kinase in Cancer

(2016) Christopher J. Matheson et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading

(2016) Sissel Hauge et al.   Oncotarget

Signaling from Mus81-Eme2-Dependent DNA Damage Elicited by Chk1 Deficiency Modulates Replication Fork Speed and Origin Usage

(2016) Hervé Técher et al.   Cell Reports

The Fcp1-Wee1-Cdk1 axis affects spindle assembly checkpoint robustness and sensitivity to antimicrotubule cancer drugs

(2015) R Visconti et al.   CELL DEATH AND DIFFERENTIATION

Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells

(2015) Chad M. Toledo et al.   Cell Reports

Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors

(2014) Edward Sausville et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Replication stress and cancer: It takes two to tango

(2014) Emilio Lecona et al.   EXPERIMENTAL CELL RESEARCH

Untangling the ATR-CHEK1 network for prognostication, prediction and therapeutic target validation in breast cancer

(2014) Tarek M.A. Abdel-Fatah et al.   Molecular Oncology

WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis

(2014) A Vassilopoulos et al.   ONCOGENE

Phase I, dose-escalation study of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours

(2013) Takashi Seto et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

(2013) Luis Ignacio Toledo et al.   CELL

Centromere fragmentation is a common mitotic defect of S and G2checkpoint override

(2013) Neil Beeharry et al.   CELL CYCLE

Upregulation of the ATR-CHEK1 pathway in oral squamous cell carcinomas

(2013) Rahul A. Parikh et al.   GENES CHROMOSOMES & CANCER

ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage

(2013) Armin M. Gamper et al.   NUCLEIC ACIDS RESEARCH

Various modes of cell death induced by DNA damage

(2012) O Surova et al.   ONCOGENE

Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit

(2012) Roberta Visconti et al.   Nature Communications

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy

(2011) M Bartucci et al.   CELL DEATH AND DIFFERENTIATION

Thr-1989 Phosphorylation Is a Marker of Active Ataxia Telangiectasia-mutated and Rad3-related (ATR) Kinase

(2011) Edward A. Nam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease

(2011) Raquel Domínguez-Kelly et al.   JOURNAL OF CELL BIOLOGY

Inhibitory Phosphorylation of Cyclin-Dependent Kinase 1 as a Compensatory Mechanism for Mitosis Exit

(2011) J. P. H. Chow et al.   MOLECULAR AND CELLULAR BIOLOGY

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR

(2011) Philip M Reaper et al.   Nature Chemical Biology

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations

(2011) Luis I Toledo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibition of Ataxia Telangiectasia- and Rad3 -Related Function Abrogates the In Vitro and In Vivo Tumorigenicity of Human Colon Cancer Cells Through Depletion of the CD133+ Tumor-Initiating Cell Fraction

(2011) Eike Gallmeier et al.   STEM CELLS

Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis

(2010) Mary Mohrin et al.   Cell Stem Cell

Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase

(2010) Halfdan Beck et al.   JOURNAL OF CELL BIOLOGY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Radiation-induced cell death mechanisms

(2010) David Eriksson et al.   TUMOR BIOLOGY

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

(2009) Kok Lung Chan et al.   NATURE CELL BIOLOGY

Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs

(2008) Karen E. Gascoigne et al.   CANCER CELL

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE